The study included 28 patients with pulmonary tuberculosis and a possible postoperative hemoglobin level of less than 120 g/l. For the prevention of postoperative anemia it is used recombinant human erythropoietin alpha and iron (III) hydroxide sucrose complex. Hemoglobin levels were monitored for 4 weeks after surgery and it is estimated the need for blood transfusions. Use of recombinant human erythropoietin and iron sucrose in patients with pulmonary tuberculosis increases basic hematological parameters as compared with the control group, and reduces the risk of postoperative anemia.

This article presents the experience of low-intensity electromagnetic radiation application in the complex treatment of patients with sepsis. As a carrier of electromagnetic radiation used a standard plastic card with a magnetic stripe HiCo, which were fixed on the skin projection iliac arteries. The article presents the results of treatment of 22 patients with severe sepsis criteria and multi-organ failure, whose complex treatment included, applied electromagnetic radiation. Electromagnetic radiation efficiency was studied with apoptotic lymphocyte count and concentration of dead leukocytes of venous blood, using method of flow cytometry. The study was performed before and 1 hour after the imposition of electromagnetic radiation carrier. The most pronounced effect of low-intensity electromagnetic radiation indicators noted in lymphocyte apoptosis venous blood, but these changes lymphocytes apoptotic had prominent controversial direction. Mechanisms of electromagnetic fields action on the carrier body and apoptosis remain unclear and require further study.

It was investigated the influence of chronic zoosocial stress (ZSS) and modulation of the intestinal microflora composition on the ratio of T-helper subsets in GALT. It has been established that ZSS development was accompanied by an imbalance Tbet+/Gata3+- and Foxp3 +/Roryt +-cells, indicating the dominance of Th1- and Th17-differentiation and increasing levels of pro-inflammatory signaling in the gut. It was shown that the introduction of kanamycin to the stressed rats leads to the dominance of Th1- and Treg subsets, but modulation of the intestinal microflora lactobacterine reduces the ratio of Tbet +/Gata3 + - lymphocytes in the own lamina of mucous membrane of the fibres, increases in subepithelial zone and increases unidirectionally the ratio of Treg/Th17.

Considering the rarity of occurrence of such anomalies of human development, like siamese twins, and a few reports of a descriptive nature in the available literature that would have dealt with these studies, we performed anatomical and histological, histochemical and morphometric study of spinal cord siamese twins (thoracopagus) in a comparative perspective: right - left. Found that significant differences in the structures of the spinal cord cytoarchitectonics the left and right of the fetus thoracopagus person we have not identified. However, slight differences in morphometric parameters observed at the level of the cervical and lumbosacral bulges. The results, in our view, not only complement the knowledge in human teratology, but in neuroanatomy as a whole.

Knee osteoarthritis is followed by the intensification of free radical oxidation of proteins and lipids in the blood plasma of patients. Specific pharmacotherapy leads to a significant reduction in the content of carbonyl groups, aliphatic aldehyde groups and malondialdehyde in the tested samples, and to an increase in the total protein content up to normal physiological values in half of the treated patients. The results of the study allow us to recommend the use of these indicators in laboratory diagnostics for indepth study of the degenerative dystrophic process in the knee joint, as well as to monitor the progress of therapy and to evaluate the effectiveness of therapeutic interventions.

In the research on rabbits influence of combined oral contraceptive "Yarina" on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of marker substrate fexofenadine. It was found that administration of the drug "Yarina" for 14 and 21 days resulting in inhibition of Pgp functional activity.

A total of 30 men with hypertension and 20 men with post-infarction cardiosclerosis were examined. The analysis of association of polymorphisms of genes which participate in a biogenesis of microRNAs (miRNAs), such as AGO1 (A/G), DGCR8 (G/A), GEMIN4 (A/G), DROSHA (A/C) with a frequency of hypertension and post-infarction cardiosclerosis is carried out. The association between a genotype of AA of a gene of GEMIN4 and risk of development of hypertension is found. The results indicated about important role of this genotype in pathogenesis of hypertension, but mechanisms of realization of its effects aren’t studied.

The 165th birthday of a prominent Russian physiologist, academician Ivan Petrovich Pavlov is to be marked in September 2014. Hitherto, I.P. Pavlov is the only Nobel laureate in physiology or medicine in recognition for the work conducted in Russia (Nobel Prize winners I.I. Mechnikov, S.A. Waksman, and I.R. Prigozhin worked abroad).

The aim of this work was to determine the formation of intermitochondrial contacts during ontogenesis of mitochondrial reticulum and to evaluate the degree of mitochondria associations under the influence of prenatal hypoxia. In the present study, we analyzed that in normal conditions the number of intermitochondrial contacts was different in areas of the cell and changed to the stages of ontogeny. Influence of intrauterine hypoxia and oxidative stress leads to mitochondrial reactions that affects to the formation between organelles intermitochondrial contacts in the sub-sarcolemmal, intermyoflbrillar and paranuclear regions of ventricle cardiomyocytes.

The article is devoted to the peculiarities of the organization of spectral EEG patterns in medical school students studying the foreign language. It is shown that students successfully mastering the training program have a higher absolute spectral power of the alpha, beta, and theta rhythms of the left hemisphere. Students with a low level of knowledge of foreign language speech revealed to have mostly right hemisphere dominance. Functional tests with listening texts in a foreign language, as familiar and not previously studied, revealed the specialization of hemispheres in respect to acoustic prosody of foreign languages.

The materials on the development of analytical methods for paracetamol using a spectrometric technique in the pharmaceutical substance, medicinal forms and biological liquids are presented in the paper.

Differences in the morphofunctional state of the immune system of female Wistar rats in different phases of the estrous cycle are revealed. In the phase of diestrus the indices of cortex volume fraction of thymus and volume fraction of white pulp and marginal zone of lymphoid follicles of spleen are higher; the indices of subcapsular layer width of thymus and index of stimulation of granulocytes in the peripheral blood are lower as compared with the phase of proestrus. Differences in the absolute count and the percentage of T and B lymphocytes, T helpers, cytotoxic, activated and regulatory T cells in the peripheral blood of female rats in the phases of proestrus and diestrus aren’t revealed.

The material is given in article about activity of the founder of the domestic school of pharmacologists of the academician N. P. Kravkov in the years of World War I devoted to the first centenary of its beginning. On the instructions of the military department N.P. Kravkov actively participated in the work on studying of war poisoning gases in connection with the beginning of their application by armies of the opponent. Within the same years N.P. Kravkov performed scientific works on toxicology of the Caucasian gasolines.

Different technological approaches to development of dairy products determine the organization of the labor process. Qualitative and quantitative hygienic evaluation of the working process in different professional groups allows you to identify deficiencies and develop a complex management decisions on its optimization.

The inflammatory process in any localization is accompanied by an increase of the enzymatic activity in the focus of inflammation and blood, which is an important patogenenetic element in the development and result of inflammation in the uterus in normal postopartum and postpartum complicated by endometritis. There was the research of activity of the lysosomal enzymes (cathepsin D, β-D-galactosidase, DNA-ase) for determining of their clinical significance in the diagnostics and controlling of their efficiency of treatment of postpartum endometritis. Identified changes in the concentration of these enzymes in metroaspirate are more informative to measure the severity of the inflammatory process in the uterus.

In a study on rabbits the effect of experimental manipulations (false surgery and distilled water administration) on functional P-glycoprotein activity was studied. P-glycoprotein activity was assessed by pharmacokinetic analysis of its marker substrate - fexofenadine. Found that manipulations applied do not lead to modulation of Pgp activity at all stages of the research period.

The review is devoted to the analysis of the modern conceptions about role of specific regulatory protein HIF-1α (hypoxia-inducible factor-1alpha) in the mechanisms of adaptation to hypoxia. Experimental and clinical results of using of different HIF-1α inducers (inhibitors of HIF-1α degradation and inactivation, activators of transcription and translation of HIF-1α) to activate the processes of immediate and delayed organism adaptation to hypoxia is discussed in the article. This approach opens promising opportunities for effective pharmacotherapy of cardiovascular and other diseases with hypoxia and ischemia in their pathogenesis.

In the article based on the result of simulation modeling there are maximum one time concentrations of carcinogens, released to the air with emission of stationary sources. We did comparative analysis of the air pollution levels in the service districts of children's city polyclinics according to annual mean concentrations of individual carcinogens in the air and percentage of the receptor points where their calculated concentrations did not comply with the hygienic norms.

We have studied 99 lateral teleroentgenograms of the scull made in patients aged 20 to 45. There were 48 patients with physiological occlusion of dentition, 36 patients with distal occlusion and 15 patients with mesial occlusion of dentition. We have identified four basic forms of the lower boundary of the maxillary sinus and 3 types of its vertical distance from the basis of maxilla (line ANS-PNS) in the portions corresponding to the position of the premolars’ and molars’ root tips. We have compared the frequency of the location of the posterior teeth’s root tips above the lower boundary of the sinus for various types of dental occlusion. This analysis is important for forecasting outcomes of orthodontic mesial/distal movement of posterior teeth, as well as for replacement of defects of the upper denture by implant-supported prostheses.

82 patients with asthma and comorbid essential hypertension were examined with the aim of intravenous lasertherapy and interval normobaric hypoxytherapy evaluation in combined pathology complex therapy. Physical factors including in therapy of patients with this combined pathology definitely improves condition and functional indexes; positive dynamics expression also might help drugs dose decreasing. It allows recommend intravenous lasertherapy and interval normobaric hypoxytherapy adding to basic medicinal therapy.

The paper studied the effect of surgical damage, applied during hernia repair, on morphology and function of male sex glands and fertility forecast for example 24 patients of reproductive age undergoing surgery for inguinal hernia. Depending on the method of hernia repair the dynamics of indicators of testicular blood flow by dopplerography, the average levels of sex hormones in blood plasma and spermiogram in the preoperative and postoperative period was studied. Based on the analysis of the data revealed a low-impact way of inguinal hernia repair, has minimal impact on the male reproductive function.

The assessment of deadlines for dispensary registration of pregnant and regularity of their observations are presented in article and also the relation of the surveyed women to work of "School of pregnant women". We used in the work the results of the survey 672 postpartum women living in Ryazan.

In the article various theoretical approaches in studying risk behavior are discussed, and also the attempt to consider the phenomenon of risk according to the general theory of the functional systems of academician P. K. Anokhin is made. The theoretical statements proving the possible addictive nature of the activity associated with risk are given. It is supposed that the readiness for the risk represents a particular specific motivational condition which, under the terms of uncertainty, is integrated into a functional system. The risk is considered as the independent component of the system organization of an individual purposeful behavior.

The results present the research of parameters of the efficacy and safety of thrombolytic therapy (TLT) actilyse in 95 patients with myocardial infarction, depending on age. Observed increase in 28-day mortality and incidence of undesirable effects in individuals TLT older age groups. Peculiarities of reperfusion arrhythmias and conduction in the TLT aktilyse patients were 75 years and older, the prevalence of AV-blockade and ventricular exstrasystols.

In an article, on the analysis of literature data, studied and intercellular ceU-matkrisnyh interactions in breast tumors. Analyzed in the data that are important for understanding the processes of intercellular interactions and patterns of tumor growth. Tumor microenvironment is important for the regulation of tumor status.