In times of radical change, we need to look into cities as laboratories. A sheer unlikely candidate for such an urban laboratory is the city of Sarajevo. Yet, the city’s turbulent past of alternating periods of construction and destruction and the variety of social, cultural, and political layers in its built environment reveal challenges and potentials relevant to the state of many contemporary cities around the globe. Sarajevo’s discontinuous political, social, and historical development has created a bricolage city. By highlighting the existing local socio-cultural and ecological systems, the Urban-Think Tank’s “Reactivate Sarajevo” project aims not only to contribute to a post-war revitalization of the Bosnian capital but also to produce, from the experience of this extraordinary city, lessons of wider, possibly global significance.