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Frontiers of Materials Science

Front. Mater. Sci.    2016, Vol. 10 Issue (2) : 113-121     DOI: 10.1007/s11706-016-0339-7
RESEARCH ARTICLE |
The multifunctional wound dressing with core–shell structured fibers prepared by coaxial electrospinning
Qilin WEI1,Feiyang XU1,Xingjian XU1,Xue GENG1,2,Lin YE1,2,*(),Aiying ZHANG1,2,Zengguo FENG1,2
1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
2. Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, Beijing 100081, China
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Abstract

The non-woven wound dressing with core–shell structured fibers was prepared by coaxial electrospinning. The polycaprolactone (PCL) was electrospun as the fiber’s core to provide mechanical strength whereas collagen was fabricated into the shell in order to utilize its good biocompatibility. Simultaneously, the silver nanoparticles (Ag-NPs) as anti-bacterial agent were loaded in the shell whereas the vitamin A palmitate (VA) as healing-promoting drug was encapsulated in the core. Resulting from the fiber’s core–shell structure, the VA released from the core and Ag-NPs present in the shell can endow the dressing both heal-promoting and anti-bacteria ability simultaneously, which can greatly enhance the dressing’s clinical therapeutic effect. The dressing can maintain high swelling ratio of 190% for 3 d indicating its potential application as wet dressing. Furthermore, the dressing’s anti-bacteria ability against Staphylococcus aureus was proved by in vitro anti-bacteria test. The in vitro drug release test showed the sustainable release of VA within 72 h, while the cell attachment showed L929 cells can well attach on the dressing indicating its good biocompatibility. In conclusion, the fabricated nanofibrous dressing possesses multiple functions to benefit wound healing and shows promising potential for clinical application.

Keywords coaxial electrospinning      core–shell structure      multifunctional wound dressing      anti-bacteria      heal-promoting     
Corresponding Authors: Lin YE   
Online First Date: 22 April 2016    Issue Date: 11 May 2016
 Cite this article:   
Qilin WEI,Feiyang XU,Xingjian XU, et al. The multifunctional wound dressing with core–shell structured fibers prepared by coaxial electrospinning[J]. Front. Mater. Sci., 2016, 10(2): 113-121.
 URL:  
http://journal.hep.com.cn/foms/EN/10.1007/s11706-016-0339-7
http://journal.hep.com.cn/foms/EN/Y2016/V10/I2/113
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Qilin WEI
Feiyang XU
Xingjian XU
Xue GENG
Lin YE
Aiying ZHANG
Zengguo FENG
Fig.1  (a) Schematic figure of core–shell fiber. (b)(c)(d) SEM images of electrospinning fibers under different core–shell feeding ratios (feeding rate (core) : feeding rate (shell) = 3:1 (b), 2:1 (c), and 1:1 (d)).
Fig.2  TEM images of electrospinning fibers under different core?shell feeding ratio: (a) 3:1; (b) 2:1; (c) 1:1.
Fig.3  IR spectra of PCL, collagen, VA and the dressing.
Fig.4  The swelling ratio of the dressings.
Fig.5  The characterization of Ag-NPs in the dressing: (a) UV spectrum of Ag-NPs; (b)(c) XRD patterns of Ag-NPs.
Fig.6  Anti-bacteria evaluation against Staphylococcus aureus: (a) control group; (b) dressings loaded with Ag-NPs and VA.
Fig.7  In vitro release curve of vitamin A palmitate.
Fig.8  SEM images of L929 cell attachment on dressings.
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