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Frontiers of Materials Science

Front Mater Sci    2013, Vol. 7 Issue (2) : 118-128     DOI: 10.1007/s11706-013-0207-7
Multifunctional nanoparticle systems for combined chemo- and photothermal cancer therapy
Hai WANG1, Yu-Liang ZHAO1,2(), Guang-Jun NIE1()
1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology (NCNST), 11 Beiyitiao, Zhongguancun, Beijing 100190, China; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
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Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy of hyperthermal therapy has recently been enhanced by the development of functional nanomaterials. The unique physicochemical properties of nanomaterials afford the specific localization of hyperthermia to primary tumors and early-stage cancers. In particular, due to their high rate of light-to-heat conversion and their capacity to be activated by tissue-penetrating electromagnetic radiation, near-infrared (NIR) light-absorbing plasmonic nanomaterials have attracted considerable attention as candidates for noninvasive photothermal therapy. The purpose of this article is to provide a overview on the current development in multifunctional nanomaterials capable of combined hyperthermia-chemotherapy delivery.

Keywords combination therapy      multifunctional nanoparticle      drug delivery      hyperthermia      photothermal therapy     
Corresponding Authors: ZHAO Yu-Liang, (Y.L.Z.); NIE Guang-Jun, (G.J.N.)   
Issue Date: 05 June 2013
 Cite this article:   
Hai WANG,Yu-Liang ZHAO,Guang-Jun NIE. Multifunctional nanoparticle systems for combined chemo- and photothermal cancer therapy[J]. Front Mater Sci, 2013, 7(2): 118-128.
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Yu-Liang ZHAO
Guang-Jun NIE
1 Ferlay J, Shin H-R, Bray F, . Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer , 2010, 127(12): 2893–2917
2 Glimelius B, Hoffman K, Sj?dén P O, . Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Annals of Oncology , 1996, 7(6): 593–600
3 Ferlay J, Autier P, Boniol M, . Estimates of the cancer incidence and mortality in Europe in 2006. Annals of Oncology , 2007, 18(3): 581–592
4 McConnell J D, Roehrborn C G, Bautista O M, . The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. The New England Journal of Medicine , 2003, 349(25): 2387–2398
5 O’Shaughnessy J, Miles D, Vukelja S, . Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results. Journal of Clinical Oncology , 2002, 20(12): 2812–2823
6 Bendas G, Rothe U, Scherphof G L, . The influence of repeated injections on pharmacokinetics and biodistribution of different types of sterically stabilized immunoliposomes. Biochimica et Biophysica Acta , 2003, 1609(1): 63–70
7 Wilson K D, Raney S G, Sekirov L, . Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles. International Immunopharmacology , 2007, 7(8): 1064–1075
8 Glazer E S, Curley S A. The ongoing history of thermal therapy for cancer. Surgical Oncology Clinics of North America , 2011, 20(2): 229–235
9 Hildebrandt B, Wust P, Ahlers O, . The cellular and molecular basis of hyperthermia. Critical Reviews in Oncology/Hematology , 2002, 43(1): 33–56
10 Wust P, Hildebrandt B, Sreenivasa G, . Hyperthermia in combined treatment of cancer. The Lancet Oncology , 2002, 3(8): 487–497
11 Issels R D. Hyperthermia adds to chemotherapy. European Journal of Cancer , 2008, 44(17): 2546–2554
12 Issels R, Hyperthermia combined with chemotherapy — biological rationale, clinical application, and treatment results. Onkologie , 1999, 22(5): 374–381
13 Falk M H, Issels R D. Hyperthermia in oncology. International Journal of Hyperthermia , 2001, 17(1): 1–18
14 Takahashi I, Emi Y, Hasuda S, . Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. Surgery , 2002, 131(1 Supplement 1): S78–S84
15 Cella D F, Tulsky D S, Gray G, . The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. Journal of Clinical Oncology , 1993, 11(3): 570–579
16 Peer D, Karp J M, Hong S, . Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology , 2007, 2(12): 751–760
17 Ferrari M. Cancer nanotechnology: opportunities and challenges. Nature Reviews. Cancer , 2005, 5(3): 161–171
18 Melancon M P, Zhou M, Li C. Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Accounts of Chemical Research , 2011, 44(10): 947–956
19 Sanvicens N, Marco M P. Multifunctional nanoparticles — properties and prospects for their use in human medicine. Trends in Biotechnology , 2008, 26(8): 425–433
20 Wainwright M. Therapeutic applications of near-infrared dyes. Coloration Technology , 2010, 126(3): 115–126
21 Mohamed F, Marchettini P, Stuart O A, . Thermal enhancement of new chemotherapeutic agents at moderate hyperthermia. Annals of Surgical Oncology , 2003, 10(4): 463–468
22 Yuan A, Wu J, Tang X, . Application of near-infrared dyes for tumor imaging, photothermal, and photodynamic therapies. Journal of Pharmaceutical Sciences , 2013, 102(1): 6–28
23 Lindner L H, Eichhorn M E, Eibl H, . Novel temperature-sensitive liposomes with prolonged circulation time. Clinical Cancer Research , 2004, 10(6): 2168–2178
24 Lovell J F, Jin C S, Huynh E, . Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nature Materials , 2011, 10(4): 324–332
25 Manchanda R, Fernandez-Fernandez A, Nagesetti A, . Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents. Colloids and Surfaces B: Biointerfaces , 2010, 75(1): 260–267
26 Zheng X, Xing D, Zhou F, . Indocyanine green-containing nanostructure as near infrared dual-functional targeting probes for optical imaging and photothermal therapy. Molecular Pharmaceutics , 2011, 8(2): 447–456
27 Zheng X, Zhou F, Wu B, . Enhanced tumor treatment using biofunctional indocyanine green-containing nanostructure by intratumoral or intravenous injection. Molecular Pharmaceutics , 2012, 9(3): 514–522
28 von Maltzahn G, Park J H, Agrawal A, . Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Research , 2009, 69(9): 3892–3900
29 Hu M, Chen J, Li Z Y, . Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chemical Society Reviews , 2006, 35(11): 1084–1094
30 Hirsch L R, Jackson J B, Lee A, . A whole blood immunoassay using gold nanoshells. Analytical Chemistry , 2003, 75(10): 2377–2381
31 Averitt R D, Westcott S L, Halas N J. Linear optical properties of gold nanoshells. Journal of the Optical Society of America B , 1999, 16(10): 1824–1832
32 Shi W, Sahoo Y, Swihart M T, . Gold nanoshells on polystyrene cores for control of surface plasmon resonance. Langmuir , 2005, 21(4): 1610–1617
33 Wu G, Mikhailovsky A, Khant H A, . Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. Journal of the American Chemical Society , 2008, 130(26): 8175–8177
34 Melancon M P, Lu W, Yang Z, . In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Molecular Cancer Therapeutics , 2008, 7(6): 1730–1739
35 Liu H, Liu T, Wu X, . Targeting gold nanoshells on silica nanorattles: a drug cocktail to fight breast tumors via a single irradiation with near-infrared laser light. Advanced Materials , 2012, 24(6): 755–761
36 Lee S-M, Park H, Choi J-W, . Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells. Angewandte Chemie International Edition , 2011, 50(33): 7581–7586
37 Park H, Yang J, Lee J, . Multifunctional nanoparticles for combined doxorubicin and photothermal treatments. ACS Nano , 2009, 3(10): 2919–2926
38 Lee S-M, Park H, Yoo K-H. Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles. Advanced Materials , 2010, 22(36): 4049–4053
39 Kennedy L C, Bickford L R, Lewinski N A, . A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies. Small , 2011, 7(2): 169–183
40 Gao J, Bender C M, Murphy C J. Dependence of the gold nanorod aspect ratio on the nature of the directing surfactant in aqueous solution. Langmuir , 2003, 19(21): 9065–9070
41 Jain P K, Lee K S, El-Sayed I H, . Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. The Journal of Physical Chemistry B , 2006, 110(14): 7238–7248
42 Zhang Z, Wang L, Wang J, . Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Advanced Materials , 2012, 24(11): 1418–1423
43 Hauck T S, Jennings T L, Yatsenko T, . Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia. Advanced Materials , 2008, 20(20): 3832–3838
44 Dickerson E B, Dreaden E C, Huang X, . Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Letters , 2008, 269(1): 57–66
45 Tang H, Shen S, Guo J, . Gold nanorods@mSiO2 with a smart polymer shell responsive to thermo/near-infrared light for chemo-photothermal therapy. Journal of Materials Chemistry , 2012, 22(31): 16095–16103
46 Xiao Y, Hong H, Matson V Z, . Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging. Theranostics , 2012, 2(8): 757–768
47 Chen R, Zheng X, Qian H, . Combined near-IR photothermal therapy and chemotherapy using gold-nanorod/chitosan hybrid nanospheres to enhance the antitumor effect. Biomaterials Science , 2013, 1(3): 285–293
48 Ren F, Bhana S, Norman D D, . Gold nanorods carrying paclitaxel for photothermal-chemotherapy of cancer. Bioconjugate Chemistry , 2013, 24(3): 376–386
49 Wei Q, Ji J, Shen J. Synthesis of near-infrared responsive gold nanorod/PNIPAAm core/shell nanohybrids via surface initiated ATRP for smart drug delivery. Macromolecular Rapid Communications , 2008, 29(8): 645–650
50 Book Newell B, Wang Y, Irudayaraj J. Multifunctional gold nanorod theragnostics probed by multi-photon imaging. European Journal of Medicinal Chemistry , 2012, 48: 330–337
51 Chen J, Glaus C, Laforest R, . Gold nanocages as photothermal transducers for cancer treatment. Small , 2010, 6(7): 811–817
52 Skrabalak S E, Chen J, Sun Y, . Gold nanocages: synthesis, properties, and applications. Accounts of Chemical Research , 2008, 41(12): 1587–1595
53 Sun Y, Xia Y. Shape-controlled synthesis of gold and silver nanoparticles. Science , 2002, 298(5601): 2176–2179
54 Chen J, Saeki F, Wiley B J, . Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Letters , 2005, 5(3): 473–477
55 Moon G D, Choi S W, Cai X, . A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release. Journal of the American Chemical Society , 2011, 133(13): 4762–4765
56 Bianco A, Kostarelos K, Prato M. Applications of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology , 2005, 9(6): 674–679
57 Shi Kam N W, O’Connell M, Wisdom J A, . Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proceedings of the National Academy of Sciences of the United States of America , 2005, 102(33): 11600–11605
58 Zhou F, Xing D, Ou Z, . Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes. Journal of Biomedical Optics , 2009, 14(2): 021009 (7 pages)
59 Moon H K, Lee S H, Choi H C. In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes. ACS Nano , 2009, 3(11): 3707–3713
60 Chakravarty P, Marches R, Zimmerman N S, . Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes. Proceedings of the National Academy of Sciences of the United States of America , 2008, 105(25): 8697–8702
61 Fisher J W, Sarkar S, Buchanan C F, . Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. Cancer Research , 2010, 70(23): 9855–9864
62 Ghosh S, Dutta S, Gomes E, . Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes. ACS Nano , 2009, 3(9): 2667–2673
63 Liu Z, Chen K, Davis C, . Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Research , 2008, 68(16): 6652–6660
64 Liu Z, Tabakman S, Welsher K, . Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Research , 2009, 2(2): 85–120
65 Zhang W, Wang C, Li Z, . Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism. Advanced Materials , 2012, 24(39): 5391–5397
66 Chen H, Müller M B, Gilmore K J, . Mechanically strong, electrically conductive, and biocompatible graphene paper. Advanced Materials , 2008, 20(18): 3557–3561
67 Liu Z, Robinson J T, Sun X, . PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. Journal of the American Chemical Society , 2008, 130(33): 10876–10877
68 Yang K, Zhang S, Zhang G, . Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Letters , 2010, 10(9): 3318–3323
69 Robinson J T, Tabakman S M, Liang Y, . Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. Journal of the American Chemical Society , 2011, 133(17): 6825–6831
70 Sherlock S P, Tabakman S M, Xie L, . Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals. ACS Nano , 2011, 5(2): 1505–1512
71 Sherlock S P, Dai H. Multifunctional FeCo-graphitic carbon nanocrystals for combined imaging, drug delivery and tumor-specific photothermal therapy in mice. Nano Research , 2011, 4(12): 1248–1260
72 Zhang W, Guo Z, Huang D, . Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide. Biomaterials , 2011, 32(33): 8555–8561
73 Reddy L H, Arias J L, Nicolas J, . Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chemical Reviews , 2012, 112(11): 5818–5878
74 Kumar C S S R, Mohammad F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Advanced Drug Delivery Reviews , 2011, 63(9): 789–808
75 Laurent S, Dutz S, H?feli U O, . Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Advances in Colloid and Interface Science , 2011, 166(1–2): 8–23
76 Ito A, Shinkai M, Honda H, . Medical application of functionalized magnetic nanoparticles. Journal of Bioscience and Bioengineering , 2005, 100(1): 1–11
77 Hu S H, Liao B J, Chiang C S, . Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs. Advanced Materials , 2012, 24(27): 3627–3632
78 Al-Jamal W T, Kostarelos K. Liposome–nanoparticle hybrids for multimodal diagnostic and therapeutic applications. Nanomedicine , 2007, 2(1): 85–98
79 Kim J, Park S, Lee J E, . Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. Angewandte Chemie International Edition , 2006, 45(46): 7754–7758
80 Ma M, Chen H, Chen Y, . Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging. Biomaterials , 2012, 33(3): 989–998
81 Sugarbaker P H, Mora J T, Carmignani P, . Update on chemotherapeutic agents utilized for perioperative intraperitoneal chemotherapy. Oncologist , 2005, 10(2): 112–122
82 Levi-Polyachenko N H, Carroll D L, Stewart IV J H. Applications of carbon-based nanomaterials for drug delivery in oncology. In: Cataldo F, Da Ros T, eds. Carbon Materials: Chemistry and Physics (Volume 1). Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes . Springer, 2008, 223 –266
83 Calderwood S K, Khaleque M A, Sawyer D B, . Heat shock proteins in cancer: chaperones of tumorigenesis. Trends in Biochemical Sciences , 2006, 31(3): 164–172
84 Zhu M, Nie G, Meng H, . Physicochemical properties determine nanomaterial cellular uptake, transport, and fate. Accounts of Chemical Research , 2013, 46(3): 622–631
85 Wang B, He X, Zhang Z, . Metabolism of nanomaterials in vivo: blood circulation and organ clearance. Accounts of Chemical Research , 2013, 46(3): 761–769
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