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Frontiers of Materials Science

Front Mater Sci    2013, Vol. 7 Issue (1) : 40-50     DOI: 10.1007/s11706-013-0193-9
REVIEW ARTICLE |
Silicate-doped hydroxyapatite and its promotive effect on bone mineralization
Zhi-Ye QIU1,2, In-Sup NOH3, Sheng-Min ZHANG1()
1. Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China; 2. Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; 3. Department of Chemical and Biological Engineering, Seoul National University of Science and Technology, Seoul 139743, Korea
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Abstract

Bone defect is one of the most common diseases in clinic. Existing therapeutic approaches have encountered many problems, such as lack of autogenous allogeneic bone and immunological rejection to allogeneic implant. Synthetic hydroxyapatite (HA) provided solutions for bone repair, since the HA is the main inorganic component of animals’ bone. However, HA has good biocompatibility, but does not possess osteogenic capability, which is of significance for modern bone repair materials. Si is an essential trace element in bone tissue, and it has been demonstrated to be able to promote bone formation. Therefore, silicate-doped hydroxyapatite (Si--HA) may serve as a promising material for bone repair, and promote bone regeneration in the repair. The current review discusses development of Si--HA, focusing on its preparation and characterization, in vitro and in vivo evaluations of the material, positive effect of Si--HA on promoting bone formation in clinical applications, and molecular mechanism investigation of such promotive effect.

Keywords silicate-doped hydroxyapatite (Si--HA)      osteogenesis      collagen biosyn-thesis      bone mineralization     
Corresponding Authors: ZHANG Sheng-Min,Email:smzhang@mail.hust.edu.cn   
Issue Date: 05 March 2013
 Cite this article:   
Zhi-Ye QIU,In-Sup NOH,Sheng-Min ZHANG. Silicate-doped hydroxyapatite and its promotive effect on bone mineralization[J]. Front Mater Sci, 2013, 7(1): 40-50.
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http://journal.hep.com.cn/foms/EN/10.1007/s11706-013-0193-9
http://journal.hep.com.cn/foms/EN/Y2013/V7/I1/40
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Fig.1  Schematic presentation of the cell lattice comparison between pure HA and Si–HA. The loss of the hydroxyl group indicates the decrease of occupancy, since the substitution of for . (Reproduced with permission from Ref. [], Copyright 2012 IOP Publishing Ltd.)
Fig.2  XRD patterns of as-prepared Si–HA samples: pure HA (a); 0.4 wt.% Si–HA (b); 0.8 wt.% Si–HA (c); 1.2 wt.% Si–HA (d); 1.6 wt.% Si–HA (e); 2 wt.% Si–HA (f); 3 wt.% Si–HA (g); 4 wt.% Si–HA (h); 5 wt.% Si–HA (i). (Reproduced with permission from Ref. [], Copyright 2012 IOP Publishing Ltd.)
Fig.3  XRD patterns of 1250°C sintered Si–HA samples: pure HA (a); 0.4 wt.% Si–HA (b); 0.8 wt.% Si–HA (c); 1.2 wt.% Si–HA (d); 1.6 wt.% Si–HA (e); 2 wt.% Si–HA (f); 3 wt.% Si–HA (g); 4 wt.% Si–HA (h); 5 wt.% Si–HA (i). (Reproduced with permission from Ref. [], Copyright 2012 IOP Publishing Ltd.)
Si sourceCa sourceP sourcePreparation methoda axisc axisCell volumeRefs.
STACHPAPPNdecreaseincreaseslight decrease[29]
TEOSCNAPHTdecreaseincreaseslight decrease[33]
STACHPAPPNslight decreaseincreaseincrease[34]
TEOSCHDAPPPNincreaseincreaseincrease[31]
STACNDAPPPNincreaseirregularincrease[35]
STACHPAPPNdecreaseincreaseincrease[36]
Tab.1  Crystal lattice variations of Si–HA with the increase of Si content []
Fig.4  Proliferation of human bMSCs on sintered Si–HA discs determined by WST-8 assay.
Fig.5  SEM observation of the viability of human bMSCs on sintered Si–HA discs.
Fig.6  Reverse-transcriptase polymerase chain reaction (RT-PCR) results of the expression of osteogenic-associated genes for 14 days on the surface of pure HA and Si–HA. Agarose gel electrophoresis results. Corresponding densitometric analysis. (Reproduced with permission from Ref. [], Copyright 2010 John Wiley and Sons)
Fig.7  Normalized volumes of new bone within pure HA and Si–HA scaffolds (data: mean, error bars= SD, *<0.05, **<0.005, ***<0.0005, ****<0.0001). (Reproduced with permission from Ref. [], Copyright 2006 Elsevier)
Fig.8  ELISA determination of P4H concentration in human bMSCs seeded on sintered Si–HA discs.
Fig.9  Schematic diagram of a probable P4H pathway that Si–HA promotes biosynthesis of collagen.
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