Heterotrimeric G-proteins: multi-dimensional regulation in plant growth, development and abiotic stress responses
Shiyuan Guo, Yingge Wang, Jiayan Wu, Xiani Zhou, Huiling Gao
Stress Biology ›› 2025, Vol. 5 ›› Issue (1) : 3.
Heterotrimeric G-proteins: multi-dimensional regulation in plant growth, development and abiotic stress responses
Heterotrimeric G-proteins, comprising Gα, Gβ, and Gγ subunits, act as crucial molecular switches for signaling transduction in all eukaryotic organisms. Through precise modulation of specific receptors or effectors coupled with heterotrimeric G-proteins in signaling cascades, plants have the capability to activate or suppress unique signaling pathways necessary for plant growth, development, and stress responses. This review provides an overview of the heterotrimeric G-proteins signaling pathway obtained to date, and highlights novel areas for future exploration and agricultural application based on the emerging significance and potential of heterotrimeric G proteins in regulating plant development and responses to abiotic stress.
[] |
Bai L, Liu Y, Mu Y, Anwar A, He C, Yan Y, Li Y, and Yu X (2018) Heterotrimeric G-Protein γ Subunit CsGG3.2 Positively Regulates the Expression of CBF Genes and Chilling Tolerance in Cucumber. Front Plant Sci 9:488. https://doi.org/10.3389/fpls.2018.00488
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
Chen Z, Galli M, and Gallavotti A. (2022). Mechanisms of temperature-regulated growth and thermotolerance in crop species. Curr Opin Plant Biol 65. https://doi.org/10.1016/j.pbi.2021.102134
|
[] |
|
[] |
|
[] |
Colaneri, Meral Tunc-Ozdemir M Fau - Huang, Ping J, Huang Jp Fau - Jones MA and Jones AM (2014) Growth attenuation under saline stress is mediated by the heterotrimeric G protein complex. BMC Plant Biol 14:129. https://doi.org/10.1186/1471-2229-14-129
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
He Z, Zhang P, Jia H, Zhang S, Nishawy E, Sun X, and Dai M (2024) Regulatory mechanisms and breeding strategies for crop drought resistance. New Crops 1:100029. https://doi.org/10.1016/j.ncrops.2024.100029
|
[] |
|
[] |
|
[] |
|
[] |
Jangam AP, Pathak RR and Raghuram N (2016) Microarray Analysis of Rice d1 (RGA1) Mutant Reveals the Potential Role of G-Protein Alpha Subunit in Regulating Multiple Abiotic Stresses Such as Drought, Salinity, Heat, and Cold. Front Plant Sci 7:11. https://doi.org/10.3389/fpls.2016.00011
|
[] |
Je BI, Xu F, Wu Q, Liu L, Meeley R, Gallagher JP, Corcilius L, Payne RJ, Bartlett ME and Jackson D (2018) The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors. eLife 7:e35673. https://doi.org/10.7554/elife.35673
|
[] |
|
[] |
|
[] |
|
[] |
Jones JC, Duffy JW, Machius M, Temple BRS, Dohlman HG and Jones AM (2011b) The Crystal Structure of a Self-Activating G Protein α Subunit Reveals Its Distinct Mechanism of Signal Initiation. Sci Signal 4:ra8. https://doi.org/10.1126/scisignal.2001446
|
[] |
Ju C, Wang C (2023) Gγ subunit AT1/GS3-the “code” of alkaline tolerance in main graminaceous crops. Stress Biol 3:9. https://doi.org/10.1007/s44154-023-00090-5
|
[] |
|
[] |
|
[] |
|
[] |
Kaur J, Roy Choudhury S, Vijayakumar A, Hovis L, Rhodes Z, Polzin R, Blumenthal D and Pandey S (2018) Arabidopsis Type III Gγ Protein AGG3 Is a Positive Regulator of Yield and Stress Responses in the Model Monocot Setaria viridis. Front Plant Sci 9:109. https://doi.org/10.3389/fpls.2018.00109
|
[] |
Kiri IZ (2023) Mechanisms of Nutrient Uptake and Assimilation Processes in Some Plants: A Review. Dutse J Pure Appl Sci 9:223–237. https://doi.org/10.4314/dujopas.v9i2b.24
|
[] |
|
[] |
|
[] |
Liang X, Li J, Yang Y, Jiang C and Guo Y (2024) Designing salt stress‐resilient crops: Current progress and future challenges. J Integr Plant Biol 66(3):303-329. https://doi.org/10.1111/jipb.13599
|
[] |
Liu Y, Wang X, Dong D, Guo L, Dong X, Leng J, Zhao B, Guo YD and Zhang N (2021) Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants. Int J Mol Sci 22:8678. https://doi.org/10.3390/ijms22168678
|
[] |
|
[] |
Luo W, Huan Q, Xu Y, Qian W, Chong K, and Zhang J (2021) Integrated global analysis reveals a vitamin E-vitamin K1 sub-network, downstream of COLD1, underlying rice chilling tolerance divergence. Cell Rep 36:109397. https://doi.org/10.1016/j.celrep.2021.109397
|
[] |
|
[] |
Ma Y, Dai X, Xu Y, Luo W, Zheng X, Zeng D, Pan Y, Lin X, Liu H, Zhang D, Xiao J, Guo X, Xu S, Niu Y, Jin J, Zhang H, Xu X, Li L, Wang W, Qian Q, Ge S, Chong K (2015b) COLD1 Confers Chilling Tolerance in Rice. Cell 160:1209–1221. https://doi.org/10.1016/j.cell.2015.01.046
|
[] |
Ma M, Zhou JM and Liang X (2024) Phosphorylation-dependent regulation of plant heterotrimeric G proteins: From activation to downstream signaling. Sci Bull. https://doi.org/10.1016/j.scib.2024.04.067
|
[] |
|
[] |
Milligan G and Kostenis E (2009) Heterotrimeric G‐proteins: a short history. British J Pharmacol 147. https://doi.org/10.1038/sj.bjp.0706405
|
[] |
|
[] |
|
[] |
|
[] |
Muhammad Aslam M, Waseem M, Jakada BH, Okal EJ, Lei Z, Saqib HSA, Yuan W, Xu W and Zhang Q (2022) Mechanisms of Abscisic Acid-Mediated Drought Stress Responses in Plants. Int J Mol Sci 23. https://doi.org/10.3390/ijms23031084
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
Peng Y, Chen L, Li S, Zhang Y, Xu R, Liu Z, Liu W, Kong J, Huang X, Wang Y, Cheng B, Zheng L, and Li Y (2018) BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis. Nat Commun 9:1522. https://doi.org/10.1038/s41467-018-03884-8
|
[] |
Peng P, Gao Y, Li Z, Yu Y, Qin H, Guo Y, Huang R and Wang J (2019) Proteomic Analysis of a Rice Mutant sd58 Possessing a Novel d1 Allele of Heterotrimeric G Protein Alpha Subunit (RGA1) in Salt Stress with a Focus on ROS Scavenging. Int J Mole Sci 20:167. https://doi.org/10.3390/ijms20010167
|
[] |
|
[] |
|
[] |
|
[] |
Springer NM, Wu Q, Regan M, Furukawa H and Jackson D (2018) Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits. PLOS Genet 14:e1007374. https://doi.org/10.1371/journal.pgen.1007374
|
[] |
|
[] |
|
[] |
Sun S, Wang L, Mao H, Shao L, Li X, Xiao J, Ouyang Y and Zhang Q (2018) A G-protein pathway determines grain size in rice. Nat Commun 9:851. https://doi.org/10.1038/s41467-018-03141-y
|
[] |
Sun W, Zhang H, Yang S, Liu L, Xie P, Li J, Zhu Y, Ouyang Y, Xie Q, Zhang H and Yu F (2023) Genetic modification of Gγ subunit AT1 enhances salt-alkali tolerance in main graminaceous crops. Nat Sci Rev 10. https://doi.org/10.1093/nsr/nwad075
|
[] |
Sun Y, Xie Z, Jin L, Qin T, Zhan C and Huang J (2024) Histone deacetylase OsHDA716 represses rice chilling tolerance by deacetylating OsbZIP46 to reduce its transactivation function and protein stability. Plant Cell 1:1913–1936. https://doi.org/10.1093/plcell/koae010
|
[] |
|
[] |
|
[] |
Tiwari R and Bisht NC (2022) The multifaceted roles of heterotrimeric G-proteins: lessons from models and crops. Planta 255:88. https://doi.org/10.1007/s00425-022-03868-5
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
Urano D, Chen JG, Botella JR and Jones AM (2013) Heterotrimeric G protein signalling in the plant kingdom. Open Biol 3:120186. https://doi.org/10.1098/rsob.120186
|
[] |
|
[] |
|
[] |
Urano D, Maruta N, Trusov Y, Stoian R, Wu Q, Liang Y, Jaiswal DK, Thung L, Jackson D, Botella JR and Jones AM (2016) Saltational evolution of the heterotrimeric G protein signaling mechanisms in the plant kingdom. Sci Signal 9:ra93. https://doi.org/10.1126/scisignal.aaf9558
|
[] |
Vavilova V, Konopatskaia I, Kuznetsova AE, Blinov A and Goncharov NP (2017) DEP1 gene in wheat species with normal, compactoid and compact spikes. BMC Genet 18:106. https://doi.org/10.1186/s12863-017-0583-6
|
[] |
Wang T, Chen X, Ju C and Wang C (2023) Calcium signaling in plant mineral nutrition: From uptake to transport. Plant commun 4:100678. https://doi.org/10.1016/j.xplc.2023.100678
|
[] |
|
[] |
Wang XQ, Ullah H, Jones AM and Assmann SM (2001) G Protein Regulation of Ion Channels and Abscisic Acid Signaling in Arabidopsis Guard Cells. Science 292:2070–2072. https://doi.org/10.1126/science.1059046
|
[] |
|
[] |
Wang Y, Lv Y, Yu H, Hu P, Wen Y, Wang J, Tan Y, Wu H, Zhu L, Wu K, Chai B, Liu J, Zeng D, Zhang G, Zhu L, Gao Z, Dong G, Ren D, Shen L, Zhang Q, Li Q, Guo L, Xiong G, Qian Q and Hu J. (2024). GR5 acts in the G protein pathway to regulate grain size in rice. Plant Commun 5:100673. https://doi.org/10.1016/j.xplc.2023.100673
|
[] |
Wu K, Wendt T, Holme I, Dockter C, Preuß A, Thomas W, Druka A, Waugh R, Hansson M and Braumann I (2016) HvDep1 Is a Positive Regulator of Culm Elongation and Grain Size in Barley and Impacts Yield in an Environment-Dependent Manner. PLoS One 11:e0168924. https://doi.org/10.1371/journal.pone.0168924
|
[] |
|
[] |
|
[] |
Xiong XX, Liu Y, Zhang LL, Li XJ, Zhao Y, Zheng Y, Yang QH, Yang Y, Min DH and Zhang XH (2023) G-Protein β-Subunit Gene TaGB1-B Enhances Drought and Salt Resistance in Wheat. Int J Mol Sci 24:7337. https://doi.org/10.3390/ijms24087337
|
[] |
Xiong M, Zhang H, Huang Y and Li Y (2024) G protein regulation in rice seed biology. Seed Biol 3:e010. https://doi.org/10.48130/seedbio-0024-0008
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
|
[] |
Zhang H, Xu Db, Chen M, Ma Yn, Xu Zs, Li Lc, Chen Yf and Ma Yz (2015b) A G-Protein β Subunit, AGB1, Negatively Regulates the ABA Response and Drought Tolerance by Down-Regulating AtMPK6-Related Pathway in Arabidopsis. PLoS One 10:e0116385. https://doi.org/10.1371/journal.pone.0116385
|
[] |
Zhang T, Xu P, Wang W, Wang S, Caruana JC, Yang HQ and Lian H (2018) Arabidopsis G-Protein β Subunit AGB1 Interacts with BES1 to Regulate Brassinosteroid Signaling and Cell Elongation. Front Plant Sci 8:2225. https://doi.org/10.3389/fpls.2017.02225
|
[] |
|
[] |
|
[] |
Zhang H, Yu F, Xie P, Sun S, Qiao X, Tang S, Chen C, Yang S, Mei C, Yang D, Wu Y, Xia R, Li X, Lu J, Liu Y, Xie X, Ma D, Xu X, Liang Z, Feng Z, Huang X, Yu H, Liu G, Wang Y, Li J, Zhang Q, Chen C, Ouyang Y and Xie Q (2023a) A Gγ protein regulates alkaline sensitivity in crops. Science 379:eade8416. https://doi.org/10.1126/science.ade8416
|
[] |
Zhang WJ, Zhou Y, Zhang Y, Su YH and Xu T (2023b) Protein phosphorylation: A molecular switch in plant signaling. Cell Rep 42:112729. https://doi.org/10.1016/j.celrep.2023.112729
|
[] |
|
[] |
|
/
〈 |
|
〉 |