WeiTsing: a new face of Ca2+-permeable channels in plant immunity

Feng-Zhu Wang, Jian-Feng Li

Stress Biology ›› 2023, Vol. 3 ›› Issue (1) : 25. DOI: 10.1007/s44154-023-00110-4

WeiTsing: a new face of Ca2+-permeable channels in plant immunity

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Abstract

Plants employ pattern- and effector-triggered immunity (PTI and ETI) to synergistically defend invading pathogens and insect herbivores. Both PTI and ETI can induce cytosolic Ca2+ spikes, despite in different spatiotemporal patterns, to activate downstream Ca2+-dependent immune signaling cascades. While multiple families of Ca2+-permeable channels at the plasma membrane have been uncovered, the counterparts responsible for Ca2+ release from intracellular stores remain poorly understood. In a groundbreaking paper published recently by Cell, the authors reported that WeiTsing, an Arabidopsis endoplasmic reticulum (ER)-resident protein that was specifically expressed in the pericycle upon Plasmodiophora brassicae (Pb) infection, could form resistosome-like Ca2+-conducting channel and protect the stele of Brassica crops from Pb colonization. As the channel activity of WeiTsing was indispensable for its immune function, the findings highlight a previously underappreciated role of Ca2+ release from intracellular repertoire in promoting plant disease resistance.

Keywords

Plant immunity / Ca2+-permeable channel / Endoplasmic reticulum / Plasmodiophora brassicae / Brassica crop

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Feng-Zhu Wang, Jian-Feng Li. WeiTsing: a new face of Ca2+-permeable channels in plant immunity. Stress Biology, 2023, 3(1): 25 https://doi.org/10.1007/s44154-023-00110-4

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Funding
National Natural Science Foundation of China(32125004)

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