Modification of the susceptibility gene TaPsIPK1 - a win-win for wheat disease resistance and yield

Abstract

Wheat is one of the most important cereal crops, and it is essential for worldwide food security. However, wheat production is threatened by various diseases, including wheat stripe rust caused by the fungus Puccinia striiformis f. sp. tritici (Pst). The development of plant resistance against disease is usually challenged by potential reduction in crop yield due to the enhancement of plant immunity. In a recent article, Wang et al. found that TaPsIPK1 is a susceptibility gene targeted by rust effectors. Editing of TaPsIPK1 increases resistance to stripe rust without any developmental effects or yield penalty, providing an exceptional resource for developing disease resistance in wheat.

Keywords

Wheat / Wheat stripe rust / TaPsIPK1 / Resistance genes

References

[1] CarmonaMA, SautuaFJ, Pérez-HernándezO, GrossoC, VettorelloL, MilanesioB, HovmøllerMS. Rapid emergency response to yellow rust epidemics caused by newly introduced lineages of Puccinia striiformis f. sp. tritici in Argentina. Tropical Plant Pathol, 2019, 44: 385-391

[2] ChenW, WellingsC, ChenX, KangZ, LiuT. Wheat stripe (yellow) rust caused by Puccinia striiformis f. sp. tritici. Mol. Plant Pathol, 2014, 15(5):433-446

[3] ChenXM. Epidemiology and control of stripe rust (Puccinia striiformis f. sp. tritici) on wheat. Can. J Plant Pathol, 2005, 27(3):314-337

[4] Chen XM, Kang ZS (2017) Stripe rust. (ed. Chen XM, and Kang ZS) the Netherlands. https://doi.org/10.1007/978-94-024-1111-9_5

[5] LiSN, LinDX, ZhangYW, DengM, ChenYX, LvB, LiBS, LeiY, WangYP, ZhaoL, LiangYT, LiuJX, ChenKL, LiuZY, XiaoJ, QiuJL, GaoCX. Genome-edited powdery mildew resistance in wheat without growth penalties. Nature, 2022, 602(7897):455-460

[6] LiuT, WanA, LiuD, ChenX. Changes of races and virulence genes in Puccinia striiformis f. sp. tritici, the wheat stripe rust pathogen, in the United States from 1968 to 2009. Plant Dis, 2017, 101: 1522-1532

[7] McIntoshRA, WellingsCR, ParkRF. Wheat rusts: an atlas of resistance genes, 1995 Melbourne CSIRO Publishing

[8] PavanS, JacobsenE, VisserRGF, BaiY. Loss of susceptibility as a novel breeding strategy for durable and broad-spectrum resistance. Mol Breed, 2010, 25: 1-12

[9] Rahmatov M (2013) Sources of resistance to yellow rust and stem rust in different wheat-alien introgressions. In: Introductory paper at the Faculty of Landscape Planning, horticulture and agricultural science. Swedish Agricultural University, Uppsala. https://pub.epsilon.slu.se/10942/

[10] ShiferawB, SmaleM, BraunHJ, DuveillerE, ReynoldsM, MurichoG. Crops that feed the world 10. Past successes and future challenges to the role played by wheat in global food security. Food Secur, 2013, 5(3):291-317

[11] Singh RP, William HM, Huerta-Espino J, Rosewarne G (2004) Wheat rust in Asia: meeting the challenges with old and new technologies. In: Singh RP, William HM, Huerta-Espino J, Rosewarne G (eds) Proceedings of the 4th International Crop Science Congress, Brisbane

[12] WanAM, ChenXM, B HeZH. Wheat stripe rust in China. Aust J Agric Res, 2007, 58: 605-619

[13] WangN, TangCL, FanX, HeMY, GanPF, ZhangS, HuZY, WangXD, YanT, ShuWX, YuLG, ZhaoJR, HeJN, LiLL, WangJF, HuangXL, HuangLL, ZhouJM, KangZS, WangXJ. Inactivation of a wheat protein kinase gene confers broad-spectrum resistance to rust fungi. Cell., 2022, 185: 2961-2974

[14] WellingsCR. Global status of stripe rust: a review of historical and current threats. Euphytica, 2011, 179: 129-141

[15] WolterM, HollricherK, SalaminiF, Schulze-LefertP. The mlo resistance alleles to powdery mildew infection in barley trigger a developmentally controlled defence mimic phenotype. Mol Gen Genet, 1993, 239: 122-128

[16] WuJH, HuangS, ZengQD, LiuSJ, WangQL, MuJM, YuSZ, HanDJ, KangZS. Comparative genome-wide mapping versus extreme pool-genotyping and development of diagnostic SNP markers linked to QTL for adult plant resistance to stripe rust in common wheat. Theor Appl Genet, 2018, 131(8):1777-1792

Funding

Key Technologies Research and Development Program(2021YFA1300404); National Natural Science Foundation of China(32188102); Northwest A&F University