Polyamine-metabolizing enzymes are activated to promote the proper assembly of rice stripe mosaic virus in insect vectors

Dongsheng Jia, Huan Liu, Jian Zhang, Wenqiang Wan, Zongwen Wang, Xiaofeng Zhang, Qian Chen, Taiyun Wei

Stress Biology ›› 2022, Vol. 2 ›› Issue (1) : 10. DOI: 10.1007/s44154-021-00032-z

Polyamine-metabolizing enzymes are activated to promote the proper assembly of rice stripe mosaic virus in insect vectors

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Abstract

Both viruses and host cells compete for intracellular polyamines for efficient propagation. Currently, how the key polyamine-metabolizing enzymes, including ornithine decarboxylase 1 (ODC1) and its antizyme 1 (OAZ1), are activated to co-ordinate viral propagation and polyamine biosynthesis remains unknown. Here, we report that the matrix protein of rice stripe mosaic virus (RSMV), a cytorhabdovirus, directly hijacks OAZ1 to ensure the proper assembly of rigid bacilliform non-enveloped virions in leafhopper vector. Viral matrix protein effectively competes with ODC1 to bind to OAZ1, and thus, the ability of OAZ1 to target and mediate the degradation of ODC1 is significantly inhibited during viral propagation, which finally promotes polyamines production. Thus, OAZ1 and ODC1 are activated to synergistically promote viral persistent propagation and polyamine biosynthesis in viruliferous vectors. Our data suggest that it is a novel mechanism for rhabdovirus to exploit OAZ1 for facilitating viral assembly.

Keywords

Rice stripe mosaic virus / Rhabdovirus / Insect vector / Polyamines / OAZ1 / ODC1 / Viral assembly

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Dongsheng Jia, Huan Liu, Jian Zhang, Wenqiang Wan, Zongwen Wang, Xiaofeng Zhang, Qian Chen, Taiyun Wei. Polyamine-metabolizing enzymes are activated to promote the proper assembly of rice stripe mosaic virus in insect vectors. Stress Biology, 2022, 2(1): 10 https://doi.org/10.1007/s44154-021-00032-z

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Funding
National Natural Science Foundation of China(31970160); Natural Science Foundation of Shanghai(31871931); Natural Science Foundation of Fujian Province(2020J06015)

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