Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance
Jinshui Lin , Lei Xu , Jianshe Yang , Zhuo Wang , Xihui Shen
Stress Biology ›› 2021, Vol. 1 ›› Issue (1) : 11
Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance
Bacteria inhabit diverse and dynamic environments, where nutrients may be limited and toxic chemicals can be prevalent. To adapt to these stressful conditions, bacteria have evolved specialized protein secretion systems, such as the type VI secretion system (T6SS) to facilitate their survival. As a molecular syringe, the T6SS expels various effectors into neighboring bacterial cells, eukaryotic cells, or the extracellular environment. These effectors improve the competitive fitness and environmental adaption of bacterial cells. Although primarily recognized as antibacterial weapons, recent studies have demonstrated that T6SSs have functions beyond interspecies competition. Here, we summarize recent research on the role of T6SSs in microbiome modulation, pathogenesis, and stress resistance.
National Natural Science Foundation of China,(31725003)
Postdoctoral Research Foundation of China,(2018M631201)
Shaanxi Province Postdoctoral Science Foundation,(2018BSHTDZZ20)
national key r&d program of china,(2018YFA0901200)
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