Developing organs-on-chips for biomedical applications
Lingyu Sun , Hanxu Chen , Dongyu Xu , Rui Liu , Yuanjin Zhao
Smart Medicine ›› 2024, Vol. 3 ›› Issue (2) : 20240009
Developing organs-on-chips for biomedical applications
In recent years, organs-on-chips have been arousing great interest for their bionic and stable construction of crucial human organs in vitro. Compared with traditional animal models and two-dimensional cell models, organs-onchips could not only overcome the limitations of species difference and poor predict ability but also be capable of reappearing the complex cell-cell interaction, tissue interface, biofluid and other physiological conditions of humans. Therefore, organs-on-chips have been regarded as promising and powerful tools in diverse fields such as biology, chemistry, medicine and so on. In this perspective, we present a review of organs-on-chips for biomedical applications. After introducing the key elements and manufacturing craft of organson- chips, we intend to review their cut-edging applications in biomedical fields, incorporating biological analysis, drug development, robotics and so on. Finally, the emphasis is focused on the perspectives of organs-on-chips.
biosensing / cell culture / drug screening / microfluidics / organs-on-chips / tissue engineering
2024 The Authors. Smart Medicine published by Wiley‐VCH GmbH on behalf of Wenzhou Institute, University of Chinese Academy of Sciences.
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