Resolving the L-abrine residual bottleneck: enzyme engineering facilitates its dimethylation into L-hypaphorine

Ming-Xin Sun , Zi-Wen Xie , Zheng-Heng Qian , Jian-Zhong Xu

Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) : 75

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Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) :75 DOI: 10.1007/s43393-026-00476-2
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Resolving the L-abrine residual bottleneck: enzyme engineering facilitates its dimethylation into L-hypaphorine
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SAM-dependent methyltransferase / L-Abrine / Biocatalysis / Semi-rational engineering / Molecular dynamics simulations

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Ming-Xin Sun, Zi-Wen Xie, Zheng-Heng Qian, Jian-Zhong Xu. Resolving the L-abrine residual bottleneck: enzyme engineering facilitates its dimethylation into L-hypaphorine. Systems Microbiology and Biomanufacturing, 2026, 6(3): 75 DOI:10.1007/s43393-026-00476-2

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Funding

Innovative Research Group Project of the National Natural Science Foundation of China(32271534)

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Jiangnan University

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