Enhancing the solubility and thermostability of nitrilase through surface hydrophobic residue engineering

Ziyi Li , Yina Ren , Yuxuan Jiang , Chenlan Yan , Yiqi Deng , Yiyi Li , Zhemin Zhou , Laichuang Han

Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) : 72

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Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) :72 DOI: 10.1007/s43393-026-00473-5
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Enhancing the solubility and thermostability of nitrilase through surface hydrophobic residue engineering
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Nitrilase / Solubility / sfGFP fusion / Stability / Soluble expression

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Ziyi Li, Yina Ren, Yuxuan Jiang, Chenlan Yan, Yiqi Deng, Yiyi Li, Zhemin Zhou, Laichuang Han. Enhancing the solubility and thermostability of nitrilase through surface hydrophobic residue engineering. Systems Microbiology and Biomanufacturing, 2026, 6(3): 72 DOI:10.1007/s43393-026-00473-5

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Funding

National Key Research and Development Program of China(2023YFA0914500))

Jiangsu Basic Research Center for Synthetic Biology(BK20233003)

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Jiangnan University

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