Engineering the substrate-binding pocket of N-acetylserotonin O-methyltransferase for efficient melatonin biosynthesis

Lirong Chen , Wenzhao Xu , Ling Gao , Xiaole Xia

Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) : 63

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Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (3) :63 DOI: 10.1007/s43393-026-00456-6
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Engineering the substrate-binding pocket of N-acetylserotonin O-methyltransferase for efficient melatonin biosynthesis
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N-acetylserotonin O-methyltransferase / Melatonin / Binding pocket engineering / Protein engineering / Whole-cell biosynthesis

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Lirong Chen, Wenzhao Xu, Ling Gao, Xiaole Xia. Engineering the substrate-binding pocket of N-acetylserotonin O-methyltransferase for efficient melatonin biosynthesis. Systems Microbiology and Biomanufacturing, 2026, 6(3): 63 DOI:10.1007/s43393-026-00456-6

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Funding

Jiangsu Basic Research Center for Synthetic Biology(BK20233003)

China Postdoctoral Science Foundation(2024M751149)

RIGHTS & PERMISSIONS

Jiangnan University

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