The Human Genome Project: the Beginning of the Beginning

Abstract

In May 1985 there was at University of California Santa Cruz an influential meeting that was the first serious discussion of sequencing the entire human genome. The author was one of the participants and described the meeting and related issues.

Graphical abstract

References

[1] Galas, D. J., Patrinos, A. and Delisi, C. (2017) Notes from a revolution: lessons from the Human Genome Project. Issues Sci. Technol., 57–62

[2] Robert Cook-Deegan. (1994) The Gene Wars: Science, Politics, and the Human Genome. New York: W. W. Norton and Company, Inc.

[3] National Research Council. (1988) Mapping and Sequencing the Human Genome. Washington, DC: The National Academies

[4] Green, E. D., Watson, J. D. and Collins, F. S. (2015) Human Genome Project: Twenty-five years of big biology. Nature, 526, 29–31

[5] Lander, E. S. and Waterman, M. S. (1988) Genomic mapping by fingerprinting random clones: a mathematical analysis. Genomics, 2, 231–239

[6] Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860–921

[7] Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., (2001) The sequence of the human genome. Science, 291, 1304–1351

[8] Miga, K. H., Koren, S., Rhie, A., Vollger, M. R., Gershman, A., Bzikadze, A., Brooks, S., Howe, E., Porubsky, D., Logsdon, G. A., (2020) Telomere-to-telomere assembly of a complete human X chromosome. Nature, 585, 79–84

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