Glioblastoma multiforme (GBM) is a common central nervous system malignancy with poor survival despite new treatments. Although some evidence demonstrated the prognostic effects of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and urothelial carcinoma associated 1 (UCA1) long non-coding RNAs (lncRNAs) in patients with GBM, a comprehensive study has not yet evaluated the clinical importance of these lncRNAs. Hence, this review aimed to predict the significance of expressions of MALAT and UCA1 lncRNAs in patients with GBM. Using proper keywords, a thorough literature search was performed via databases, including PubMed, Web of Knowledge, Scopus, and EMBASE until December 2024. The relationship between lncRNA expressions and overall survival (OS) in patients with GBM was assessed using hazard ratios (HR) and confidence intervals (95% CI), and the fixed and random effects models were used to estimate the pooled effect size. Also, the Newcastle-Ottawa Quality Assessment Scale was used as an appraisal tool. Among 1553 initially founded records, 13 studies were enrolled in the final analysis, consisting of 915 and 257 samples in the MALAT1 and UCA1 groups, respectively. Compared to the patients with low expression, those with high expression of MALAT1 had a mortality risk of 80% (HR = 1.8, 95% CI = [1.39, 2.33], p = .001). Additionally, the impact of UCA1 expression on patient prognosis indicated that lower OS among patients was correlated with high expression of UCA1; however, the meta-analysis was not performed for UCA1 due to a lack of adequate studies. According to our findings, high expression of MALAT1 was correlated with poor prognosis in patients with GBM.

To systematically evaluate the effect of nurse-led and physician-led multidisciplinary team (MDT) palliative care models on quality of life, negative emotions, and pain for cancer patients. A comprehensive literature search of randomized controlled trials (RCTs) published in nine databases was conducted. Data analysis was performed using RevMan5.3. The findings were summarized using a random effects model of mean differences with 95% confidence intervals. The search strategy identified 15 articles involving 1850 cancer patients. MDT hospice care improved quality of life among cancer patients (SMD = 1.77, 95% CI [1.08, 2.46], Z = 5.02, p < .001), with nurse-led care (SMD = 3.04, 95% CI [2.29, 3.79], Z = 7.95, p < .001) providing better effects than physician-led care (SMD = 0.5, 95% CI [0.33, 0.67], Z = 5.76, p < .001). Furthermore, MDT hospice care significantly alleviated depression (SMD = –1.31, 95% CI [−1.49, −1.12], Z = 14.18, p < .001) and anxiety (SMD = –1.11, 95%CI [−1.29, −0.92], Z = 11.69, p < .001) and reduced patients' pain (SMD = –0.92, 95% CI [−1.13, −0.7], Z = 8.37, p < .001). Nurse-led care provided better effects for relieving anxiety and depression, while physician-led care provided better effects for relieving pain. The findings of the meta-analysis indicate that MDT palliative care can improve the quality of life for cancer patients and alleviate their depression, anxiety and their pain. Nurse-led care was superior in terms of quality of life, depression, and anxiety indicators, while physician-led care had a more significant effect on pain relief.

Through bibliometric analysis of CAR-T research hotspots and development trends, a reference is provided to promote cutting-edge research on CAR-T. Acquired research literature on CAR-T cells from the Web of Science Core Collection (WOSCC) as of November 20, 2023, and utilized CiteSpace software to conduct bibliometric and knowledge graph analysis. A total of 3664 articles of valid literature were obtained between 1996 and 2023. The number of publications grew slowly from 1996 to 2014 and increased sharply from 2015. In particular, from 2018 to 2022, the number of publications showed explosive growth and remained at a high level. The authors of the papers are relatively scattered, and there is little cooperation between authors. The United States has published the most papers in this field and has close cooperation with global research institutions, while China ranks second in terms of the number of papers published and has less academic cooperation or exchanges with other countries/regions. The main research hotspots include chimeric antigen receptor, immunotherapy, cytokine release syndrome, etc., which belong to two categories: the treatment mechanism and application of CAR-T and adverse reactions and safety management. Keyword mutation analysis predicts that future research hotspots will mainly be related to technical research, safety, and post-treatment management of CAR-T. CAR-T is a hot research field and is still in a rapid development stage. Domestic researchers need to strengthen exchanges and cooperation with international researchers. CAR-T-related technical research, safety, and post-treatment management may be the hot spots of future research.

To observe the positive of stage-based physical mental combined pain reduction nursing based on pain scoring for cancer pain patients. A total of 120 cancer pain patients admitted to our hospital from December 2022 to December 2023 were selected. They were randomly divided into a control group and an observation group, with 60 cases in each group. The control group received medication intervention nursing, whereas the observation group received phased physical mental combined pain reduction nursing. The visual analogue scale (VAS) pain scores, Psychological Hope Level (HHI) score and Psychological Health Mood State Questionnaire (POMS) score of the two groups of patients were observed before nursing and at 1, 6, and 12 months after nursing. There was no difference in VAS scores between two groups at 1 month after nursing care (p > 0.05), but the observation group had lower VAS scores at 1, 6, and 12 months after nursing; In the HHI score of the observation group patients after nursing, there was no difference between the pre-nursing and 1 month post nursing scores and the control group (p > 0.05), but scores were lower than the control group at 6 and 12 months after nursing; The POMS score of the observation group patients after nursing was better than the control group. All the difference was statistically significant (p < 0.05). Our findings suggest that staged physical mental combined pain reducing care has a positive impact on patients with cancer pain.