High PSMA expression is associated with immunosuppressive tumor microenvironment in clear cell renal cell carcinoma

Panagiotis J. Vlachostergios , Athanasios Karathanasis , Konstantinos Dimitropoulos , Ioannis Zachos , Vassilios Tzortzis

Precision Clinical Medicine ›› 2024, Vol. 7 ›› Issue (2) : pbae010

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Precision Clinical Medicine ›› 2024, Vol. 7 ›› Issue (2) :pbae010 DOI: 10.1093/pcmedi/pbae010
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High PSMA expression is associated with immunosuppressive tumor microenvironment in clear cell renal cell carcinoma

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Panagiotis J. Vlachostergios, Athanasios Karathanasis, Konstantinos Dimitropoulos, Ioannis Zachos, Vassilios Tzortzis. High PSMA expression is associated with immunosuppressive tumor microenvironment in clear cell renal cell carcinoma. Precision Clinical Medicine, 2024, 7(2): pbae010 DOI:10.1093/pcmedi/pbae010

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Author contributions

P.J.V.: conceptualization, data curation, methodology, visualization, writing-original draft-review and editing, and supervision. A.K.: data curation, visualization, and writing—original draft. I.Z.: methodology, writing—review and editing. V.T.: writing—review and editing, and supervision. All authors have read and agreed to the published version of the manuscript. All authors were involved in manuscript editing and manuscript review.

Conflict of interest

None declared.

The data that support the findings of this study are available at https://www.cbioportal.org/study/summary?id=kirc_tcga_pan_can_atlas_2018, accessed on 27 January 2024.

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Spatz S, Tolkach Y, Jung K et al. Comprehensive evaluation of prostate specific membrane antigen expression in the vasculature of renal tumors: implications for imaging studies and prognostic role. J Urol 2018;199:370-7. https://doi.org/10.1016/j.juro.2017.08.079.

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Bui VN, Unterrainer LM, Brendel M et al. PSMA-expression is highly associated with histological subtypes of renal cell carcinoma: potential implications for theranostic approaches. Biomedicines 2023;11:3095. https://doi.org/10.3390/biomedicines11113095.

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Gao J, Meng L, Xu Q et al. 68Ga-PSMA-11 PET/CT parameter correlates with pathological VEGFR-2/PDGFR-βexpression in renal cell carcinoma patients. Mol Imaging Biol 2022;24:759-68. https://doi.org/10.1007/s11307-022-01725-1.

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