Protein & Cell >

2024 , Vol. 15 >Issue 4: 305 - 312

DOI: https://doi.org/10.1093/procel/pwad058

Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

  • Han Chen 1,2,3,4 ,
  • Mehar Monga 2,4,5 ,
  • Qinghua Fang 1,2,3 ,
  • Loujin Slitin 1,4,6,7 ,
  • Jakob Neef 1,2,3 ,
  • Shashank S. Chepurwar 2,4,8 ,
  • Regina Célia Mingroni Netto 9 ,
  • Karina Lezirovitz 10 ,
  • Alfredo Tabith,Jr. 11 ,
  • Fritz Benseler 12 ,
  • Nils Brose 2,12,13 ,
  • Kathrin Kusch 1,14 ,
  • Carolin Wichmann 2,6,7,13 ,
  • Nicola Strenzke 1,2,8 ,
  • Barbara Vona 1,15,16 ,
  • Julia Preobraschenski 2,5,13 ,
  • Tobias Moser , 1,2,3,13
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  • 1. Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 2. Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany
  • 3. Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany
  • 4. Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany
  • 5. Biochemistry of Membrane Dynamics Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 6. Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 7. Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 8. Auditory Systems Physiology Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 9. Departamento de Genética e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-220, Brazil
  • 10. Laboratório de Otorrinolaringologia/LIM32, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP 05508-220, Brazil
  • 11. DERDIC, Pontifícia Universidade Católica de São Paulo, São Paulo 05508-220, Brazil
  • 12. Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany
  • 13. Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany
  • 14. Functional Auditory Genomics Group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, 37077 Göttingen, Germany
  • 15. Hearing Genomics Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany
  • 16. Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany
tmoser@gwdg.de

Accepted date: 09 Nov 2023

Published date: 15 Apr 2024

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.
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Cite this article

Han Chen , Mehar Monga , Qinghua Fang , Loujin Slitin , Jakob Neef , Shashank S. Chepurwar , Regina Célia Mingroni Netto , Karina Lezirovitz , Alfredo Tabith,Jr. , Fritz Benseler , Nils Brose , Kathrin Kusch , Carolin Wichmann , Nicola Strenzke , Barbara Vona , Julia Preobraschenski , Tobias Moser . Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing[J]. Protein & Cell, 2024 , 15(4) : 305 -312 . DOI: 10.1093/procel/pwad058

References

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