Protein & Cell >

2023 , Vol. 14 >Issue 8: 623 - 628

DOI: https://doi.org/10.1093/procel/pwad012

LETTER

CRISPR-based screening identifies XPO7 as a positive regulator of senescence

  • Lan-Zhu Li 1,4,5,6 ,
  • Kuan Yang 3,4,10 ,
  • Yaobin Jing 1,4,5,6,7 ,
  • Yanling Fan 3,4 ,
  • Xiaoyu Jiang 1,4,5,6 ,
  • Si Wang 8,9 ,
  • Guang-Hui Liu , 1,4,5,6,7,8,9 ,
  • Jing Qu , 2,4,5,6 ,
  • Shuai Ma , 1,4,5,6 ,
  • Weiqi Zhang , 3,4,5,7,10
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  • 1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 2. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 3. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China
  • 4. University of Chinese Academy of Sciences, Beijing 100049, China
  • 5. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 6. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
  • 7. School of Future Technology, University of Chinese Academy of Sciences, Beijing 100190, China
  • 8. Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • 9. Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 10. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China
ghliu@ioz.ac.cn
qujing@ioz.ac.cn
mashuai@ioz.ac.cn
zhangwq@big.ac.cn

Received date: 12 Nov 2022

Accepted date: 12 Feb 2023

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.
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Cite this article

Lan-Zhu Li , Kuan Yang , Yaobin Jing , Yanling Fan , Xiaoyu Jiang , Si Wang , Guang-Hui Liu , Jing Qu , Shuai Ma , Weiqi Zhang . CRISPR-based screening identifies XPO7 as a positive regulator of senescence[J]. Protein & Cell, 2023 , 14(8) : 623 -628 . DOI: 10.1093/procel/pwad012

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Aksu M, Pleiner T, Karaca S et al. Xpo7 is a broad-spectrum exportin and a nuclear import receptor. J Cell Biol 2018;217:2329–2340.

DOI

2
Cai Y, Ji Z, Wang S et al. Genetic enhancement: an avenue to combat aging-related diseases. Life Med 2022a;1:307–318.

DOI

3
Cai Y, Song W, Li J et al. The landscape of aging. Sci China Life Sci 2022b;65:2354–2454.

DOI

4
Colussi C, Mozzetta C, Gurtner A et al. HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc Natl Acad Sci USA 2008;105:19183–19187.

DOI

5
Dickmanns A, Kehlenbach RH, Fahrenkrog B. Nuclear pore complexes and nucleocytoplasmic transport: from structure to function to disease. Int Rev Cell Mol Biol 2015;320:171–233.

DOI

6
Hattangadi SM, Martinez-Morilla S, Patterson HC et al. Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood 2014;124:1931–1940.

DOI

7
Innes AJ, Sun B, Wagner V et al. XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence. Genes Dev 2021;35:379–391.

DOI

8
Lopez-Otin C, Blasco MA, Partridge L et al. Hallmarks of aging: an expanding universe. Cell 2023;186:243–278.

DOI

9
Sun Y, Li Q, Kirkland JL. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging. Life Med 2022;1:103–119.

DOI

10
Warnon C, Bouhjar K, Ninane N et al. HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts. Aging (Albany NY) 2021;13:17978–18005.

DOI

11
Wu Z, Zhang W, Song M et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell 2018;9:333–350.

DOI

12
Yang J, Cai N, Yi F et al. Gating pluripotency via nuclear pores. Trends Mol Med 2014;20:1–7.

DOI

13
Zhang W, Qu J, Liu GH et al. The ageing epigenome and its rejuvenation. Nat Rev Mol Cell Biol 2020;21:137–150.

DOI

14
Zhao D, Chen S. Failures at every level: breakdown of the epigenetic machinery of aging. Life Med 2022;1:81–83.

DOI

15
Zhou Q, Wang Y, Yang L et al. Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. Mol Vis 2008;14:2556–2565.

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