CRISPR-based screening identifies <i>XPO7</i> as a positive regulator of senescence

Lan-Zhu Li; Kuan Yang; Yaobin Jing; Yanling Fan; Xiaoyu Jiang; Si Wang; Guang-Hui Liu; Jing Qu; Shuai Ma; Weiqi Zhang

doi:10.1093/procel/pwad012

PDF(11173 KB)

Protein Cell ›› 2023, Vol. 14 ›› Issue (8) : 623-628. DOI: 10.1093/procel/pwad012

LETTER

CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Lan-Zhu Li¹^,⁴^,⁵^,⁶ ,
Kuan Yang³^,⁴^,¹⁰ ,
Yaobin Jing¹^,⁴^,⁵^,⁶^,⁷ ,
Yanling Fan³^,⁴ ,
Xiaoyu Jiang¹^,⁴^,⁵^,⁶ ,
Si Wang⁸^,⁹ ,
Guang-Hui Liu¹^,⁴^,⁵^,⁶^,⁷^,⁸^,⁹ ,
Jing Qu²^,⁴^,⁵^,⁶ ,
Shuai Ma¹^,⁴^,⁵^,⁶ ,
Weiqi Zhang³^,⁴^,⁵^,⁷^,¹⁰

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Lan-Zhu Li, Kuan Yang, Yaobin Jing, Yanling Fan, Xiaoyu Jiang, Si Wang, Guang-Hui Liu, Jing Qu, Shuai Ma, Weiqi Zhang. CRISPR-based screening identifies XPO7 as a positive regulator of senescence. Protein Cell, 2023, 14(8): 623‒628 https://doi.org/10.1093/procel/pwad012

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Aksu M, Pleiner T, Karaca S et al. Xpo7 is a broad-spectrum exportin and a nuclear import receptor. J Cell Biol 2018;217:2329–2340. CrossRef Google scholar

[2]	Cai Y, Ji Z, Wang S et al. Genetic enhancement: an avenue to combat aging-related diseases. Life Med 2022a;1:307–318. CrossRef Google scholar

[3]	Cai Y, Song W, Li J et al. The landscape of aging. Sci China Life Sci 2022b;65:2354–2454. CrossRef Google scholar

[4]	Colussi C, Mozzetta C, Gurtner A et al. HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc Natl Acad Sci USA 2008;105:19183–19187. CrossRef Google scholar

[5]	Dickmanns A, Kehlenbach RH, Fahrenkrog B. Nuclear pore complexes and nucleocytoplasmic transport: from structure to function to disease. Int Rev Cell Mol Biol 2015;320:171–233. CrossRef Google scholar

[6]	Hattangadi SM, Martinez-Morilla S, Patterson HC et al. Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood 2014;124:1931–1940. CrossRef Google scholar

[7]	Innes AJ, Sun B, Wagner V et al. XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence. Genes Dev 2021;35:379–391. CrossRef Google scholar

[8]	Lopez-Otin C, Blasco MA, Partridge L et al. Hallmarks of aging: an expanding universe. Cell 2023;186:243–278. CrossRef Google scholar

[9]	Sun Y, Li Q, Kirkland JL. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging. Life Med 2022;1:103–119. CrossRef Google scholar

[10]	Warnon C, Bouhjar K, Ninane N et al. HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts. Aging (Albany NY) 2021;13:17978–18005. CrossRef Google scholar

[11]	Wu Z, Zhang W, Song M et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell 2018;9:333–350. CrossRef Google scholar

[12]	Yang J, Cai N, Yi F et al. Gating pluripotency via nuclear pores. Trends Mol Med 2014;20:1–7. CrossRef Google scholar

[13]	Zhang W, Qu J, Liu GH et al. The ageing epigenome and its rejuvenation. Nat Rev Mol Cell Biol 2020;21:137–150. CrossRef Google scholar

[14]	Zhao D, Chen S. Failures at every level: breakdown of the epigenetic machinery of aging. Life Med 2022;1:81–83. CrossRef Google scholar

[15]	Zhou Q, Wang Y, Yang L et al. Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. Mol Vis 2008;14:2556–2565.