CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Lan-Zhu Li; Kuan Yang; Yaobin Jing; Yanling Fan; Xiaoyu Jiang; Si Wang; Guang-Hui Liu; Jing Qu; Shuai Ma; Weiqi Zhang

doi:10.1093/procel/pwad012

Protein Cell ›› 2023, Vol. 14 ›› Issue (8) : 623 -628. DOI: 10.1093/procel/pwad012

LETTER

CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Lan-Zhu Li ¹^,⁴^,⁵^,⁶
, Kuan Yang ³^,⁴^,¹⁰
, Yaobin Jing ¹^,⁴^,⁵^,⁶^,⁷
, Yanling Fan ³^,⁴
, Xiaoyu Jiang ¹^,⁴^,⁵^,⁶
, Si Wang ⁸^,⁹
, Guang-Hui Liu ¹^,⁴^,⁵^,⁶^,⁷^,⁸^,⁹^,^†
, Jing Qu ²^,⁴^,⁵^,⁶^,^†
, Shuai Ma ¹^,⁴^,⁵^,⁶^,^†
, Weiqi Zhang ³^,⁴^,⁵^,⁷^,¹⁰^,^†

Author information +

¹. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

². State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

³. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China

⁴. University of Chinese Academy of Sciences, Beijing 100049, China

⁵. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

⁶. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

⁷. School of Future Technology, University of Chinese Academy of Sciences, Beijing 100190, China

⁸. Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

⁹. Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

¹⁰. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China

ghliu@ioz.ac.cn

qujing@ioz.ac.cn

mashuai@ioz.ac.cn

zhangwq@big.ac.cn

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Lan-Zhu Li, Kuan Yang, Yaobin Jing, Yanling Fan, Xiaoyu Jiang, Si Wang, Guang-Hui Liu, Jing Qu, Shuai Ma, Weiqi Zhang. CRISPR-based screening identifies XPO7 as a positive regulator of senescence. Protein Cell, 2023, 14(8): 623-628 DOI:10.1093/procel/pwad012

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