LETTER

An engineered xCas12i with high activity, high specificity, and broad PAM range

  • Hainan Zhang 1 ,
  • Xiangfeng Kong 1 ,
  • Mingxing Xue 1 ,
  • Jing Hu 1 ,
  • Zikang Wang 1 ,
  • Yinghui Wei 1 ,
  • Haoqiang Wang 1 ,
  • Jingxing Zhou 1 ,
  • Weihong Zhang 1 ,
  • Mengqiu Xu 1 ,
  • Xiaowen Shen 1 ,
  • Fengcai Yin 1 ,
  • Zhiyuan Ai 1 ,
  • Guangyan Huang 1 ,
  • Junhui Xia 1 ,
  • Xueqiong Song 1 ,
  • Hengbin Li 2 ,
  • Yuan Yuan 2 ,
  • Jinhui Li 1 ,
  • Na Zhong 1 ,
  • Meiling Zhang 3 ,
  • Yingsi Zhou , 1 ,
  • Hui Yang , 1,2
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  • 1. HuiEdit Therapeutics Co., Ltd., Shanghai 200120, China
  • 2. HuiGene Therapeutics Co., Ltd., Shanghai 200120, China
  • 3. Center for Reproductive Medicine, International Peace Maternity and Child Health Hospital, Innovative Research Team of High-level Local Universities in Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
yingsizhou@huidagene.com
huiyang@huidagene.com

Accepted date: 19 Oct 2022

Published date: 15 Jul 2023

Copyright

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

Cite this article

Hainan Zhang , Xiangfeng Kong , Mingxing Xue , Jing Hu , Zikang Wang , Yinghui Wei , Haoqiang Wang , Jingxing Zhou , Weihong Zhang , Mengqiu Xu , Xiaowen Shen , Fengcai Yin , Zhiyuan Ai , Guangyan Huang , Junhui Xia , Xueqiong Song , Hengbin Li , Yuan Yuan , Jinhui Li , Na Zhong , Meiling Zhang , Yingsi Zhou , Hui Yang . An engineered xCas12i with high activity, high specificity, and broad PAM range[J]. Protein & Cell, 2023 , 14(7) : 538 -543 . DOI: 10.1093/procel/pwac052

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