LETTER

Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

  • Mingyue Ma 1 ,
  • Zhenxing Zhong 1 ,
  • Yuwen Zhu 1 ,
  • Yuan Gu 1 ,
  • Ruxin Jin 1 ,
  • Zhipeng Meng 2 ,
  • Yu Wang , 1 ,
  • Fa-Xing Yu , 1
Expand
  • 1. Institute of Pediatrics, Children’s Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • 2. Department of Molecular and Cellular Pharmacology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
fd_wangyu@fudan.edu.cn
fxyu@fudan.edu.cn

Accepted date: 15 Mar 2022

Copyright

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

Cite this article

Mingyue Ma , Zhenxing Zhong , Yuwen Zhu , Yuan Gu , Ruxin Jin , Zhipeng Meng , Yu Wang , Fa-Xing Yu . Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis[J]. Protein & Cell, 2023 , 14(2) : 137 -142 . DOI: 10.1093/procel/pwac005

1
Chen W, Zhang J, Zhang P et al. Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy. FASEB J 2019;33:3451–3464.

DOI

2
Cole BK, Curto M, Chan AW et al. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol 2008;28:1274–1284.

DOI

3
Kim J, Kim YH, Kim J et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 2017;127:3441–3461.

DOI

4
Lallemand D, Curto M, Saotome I et al. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 2003;17:1090–1100.

DOI

5
McClatchey AI, Giovannini M. Membrane organization and tumorigenesis— the NF2 tumor suppressor, Merlin. Genes Dev 2005;19:2265–2277.

DOI

6
Meng Z, Moroishi T., Mottier-Pavie V et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 2015;6:8357.

DOI

7
Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011;146:873–887.

DOI

8
Stahl A, Connor KM, Sapieha P et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci 2010;51:2813–2826.

DOI

9
Torres-Ayuso P, An E, Nyswaner KM et al. TNIK is a therapeutic target in lung squamous cell carcinoma and regulates FAK activation through Merlin. Cancer Discov 2021;11:1411–1423.

DOI

10
Vitorino P, Yeung S, Crow A et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature 2015;519:425–430.

DOI

11
Wang X, Freire Valls A, Schermann G et al. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell 2017a;42:462–478 e467.

DOI

12
Wang Y, Yu A, Yu FX. The Hippo pathway in tissue homeostasis and regeneration. Protein Cell 2017b;8:349–359.

DOI

13
Wang Y, Zhu Y, Gu Y et al. Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis. Cell Rep 2021;36:109596.

DOI

14
Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 2015;163:811–828.

DOI

15
Zheng Y, Wang W, Liu B et al. Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Dev Cell 2015;34:642–655.

DOI

Outlines

/