Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

Mingyue Ma , Zhenxing Zhong , Yuwen Zhu , Yuan Gu , Ruxin Jin , Zhipeng Meng , Yu Wang , Fa-Xing Yu

Protein Cell ›› 2023, Vol. 14 ›› Issue (2) : 137 -142.

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Protein Cell ›› 2023, Vol. 14 ›› Issue (2) : 137 -142. DOI: 10.1093/procel/pwac005
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Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

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Mingyue Ma, Zhenxing Zhong, Yuwen Zhu, Yuan Gu, Ruxin Jin, Zhipeng Meng, Yu Wang, Fa-Xing Yu. Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis. Protein Cell, 2023, 14(2): 137-142 DOI:10.1093/procel/pwac005

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References

[1]

Chen W, Zhang J, Zhang P et al. Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy. FASEB J 2019;33:3451–3464.

[2]

Cole BK, Curto M, Chan AW et al. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol 2008;28:1274–1284.

[3]

Kim J, Kim YH, Kim J et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 2017;127:3441–3461.

[4]

Lallemand D, Curto M, Saotome I et al. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 2003;17:1090–1100.

[5]

McClatchey AI, Giovannini M. Membrane organization and tumorigenesis— the NF2 tumor suppressor, Merlin. Genes Dev 2005;19:2265–2277.

[6]

Meng Z, Moroishi T., Mottier-Pavie V et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 2015;6:8357.

[7]

Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011;146:873–887.

[8]

Stahl A, Connor KM, Sapieha P et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci 2010;51:2813–2826.

[9]

Torres-Ayuso P, An E, Nyswaner KM et al. TNIK is a therapeutic target in lung squamous cell carcinoma and regulates FAK activation through Merlin. Cancer Discov 2021;11:1411–1423.

[10]

Vitorino P, Yeung S, Crow A et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature 2015;519:425–430.

[11]

Wang X, Freire Valls A, Schermann G et al. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell 2017a;42:462–478 e467.

[12]

Wang Y, Yu A, Yu FX. The Hippo pathway in tissue homeostasis and regeneration. Protein Cell 2017b;8:349–359.

[13]

Wang Y, Zhu Y, Gu Y et al. Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis. Cell Rep 2021;36:109596.

[14]

Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 2015;163:811–828.

[15]

Zheng Y, Wang W, Liu B et al. Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Dev Cell 2015;34:642–655.

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The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

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