Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

Mingyue Ma, Zhenxing Zhong, Yuwen Zhu, Yuan Gu, Ruxin Jin, Zhipeng Meng, Yu Wang, Fa-Xing Yu

PDF(4301 KB)
PDF(4301 KB)
Protein Cell ›› 2023, Vol. 14 ›› Issue (2) : 137-142. DOI: 10.1093/procel/pwac005
LETTER
LETTER

Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

Author information +
History +

Cite this article

Download citation ▾
Mingyue Ma, Zhenxing Zhong, Yuwen Zhu, Yuan Gu, Ruxin Jin, Zhipeng Meng, Yu Wang, Fa-Xing Yu. Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis. Protein Cell, 2023, 14(2): 137‒142 https://doi.org/10.1093/procel/pwac005

References

[1]
Chen W, Zhang J, Zhang P et al. Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy. FASEB J 2019;33:3451–3464.
CrossRef Google scholar
[2]
Cole BK, Curto M, Chan AW et al. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol 2008;28:1274–1284.
CrossRef Google scholar
[3]
Kim J, Kim YH, Kim J et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 2017;127:3441–3461.
CrossRef Google scholar
[4]
Lallemand D, Curto M, Saotome I et al. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 2003;17:1090–1100.
CrossRef Google scholar
[5]
McClatchey AI, Giovannini M. Membrane organization and tumorigenesis— the NF2 tumor suppressor, Merlin. Genes Dev 2005;19:2265–2277.
CrossRef Google scholar
[6]
Meng Z, Moroishi T., Mottier-Pavie V et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 2015;6:8357.
CrossRef Google scholar
[7]
Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011;146:873–887.
CrossRef Google scholar
[8]
Stahl A, Connor KM, Sapieha P et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci 2010;51:2813–2826.
CrossRef Google scholar
[9]
Torres-Ayuso P, An E, Nyswaner KM et al. TNIK is a therapeutic target in lung squamous cell carcinoma and regulates FAK activation through Merlin. Cancer Discov 2021;11:1411–1423.
CrossRef Google scholar
[10]
Vitorino P, Yeung S, Crow A et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature 2015;519:425–430.
CrossRef Google scholar
[11]
Wang X, Freire Valls A, Schermann G et al. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell 2017a;42:462–478 e467.
CrossRef Google scholar
[12]
Wang Y, Yu A, Yu FX. The Hippo pathway in tissue homeostasis and regeneration. Protein Cell 2017b;8:349–359.
CrossRef Google scholar
[13]
Wang Y, Zhu Y, Gu Y et al. Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis. Cell Rep 2021;36:109596.
CrossRef Google scholar
[14]
Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 2015;163:811–828.
CrossRef Google scholar
[15]
Zheng Y, Wang W, Liu B et al. Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Dev Cell 2015;34:642–655.
CrossRef Google scholar

RIGHTS & PERMISSIONS

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
AI Summary AI Mindmap
PDF(4301 KB)

Accesses

Citations

Detail

Sections
Recommended

/