Protein & Cell >

2022 , Vol. 13 >Issue 6: 454 - 461

DOI: https://doi.org/10.1007/s13238-021-00903-1

LETTER

Low-dose chloroquine treatment extends the lifespan of aged rats

  • Wei Li 1,8 ,
  • Zhiran Zou 2,6,7,9 ,
  • Yusheng Cai 2,6,9 ,
  • Kuan Yang 4,5,7,10,11 ,
  • Si Wang 1,8,12 ,
  • Zunpeng Liu 3,6,7,9 ,
  • Lingling Geng 1,8 ,
  • Qun Chu 3,6,9 ,
  • Zhejun Ji 3,6,9 ,
  • Piu Chan 8 ,
  • Guang-Hui Liu , 1,2,6,7,8,9 ,
  • Moshi Song , 2,6,7,9 ,
  • Jing Qu , 3,6,7,9 ,
  • Weiqi Zhang , 4,5,6,7,8,10
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  • 1. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • 2. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 3. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 4. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
  • 5. China National Center for Bioinformation, Beijing 100101, China
  • 6. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 7. University of Chinese Academy of Sciences, Beijing 100049, China
  • 8. Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 9. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
  • 10. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China
  • 11. Sino-Danish Center for Education and Research, Beijing 101408, China
  • 12. Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing 400062, China

Published date: 15 Jun 2022

Copyright

2021 The Author(s) 2021
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Cite this article

Wei Li , Zhiran Zou , Yusheng Cai , Kuan Yang , Si Wang , Zunpeng Liu , Lingling Geng , Qun Chu , Zhejun Ji , Piu Chan , Guang-Hui Liu , Moshi Song , Jing Qu , Weiqi Zhang . Low-dose chloroquine treatment extends the lifespan of aged rats[J]. Protein & Cell, 2022 , 13(6) : 454 -461 . DOI: 10.1007/s13238-021-00903-1

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Aging Atlas C (2021) Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Res 49:D825–D830

DOI

2
Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M et al (2020) SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell 11:483–504

DOI

3
Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L et al (2020) Elimination of senescent cells by beta-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res 30:574–589

DOI

4
Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS et al (2016) Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep 6:20101

DOI

5
Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L et al (2019) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10:417–435

DOI

6
He W, Wang B, Yang J, Zhuang Y, Wang L, Huang X, Chen J (2014) Chloroquine Improved Carbon Tetrachloride-Induced Liver Fibrosis through Its Inhibition of the Activation of Hepatic Stellate Cells: Role of Autophagy. Biol Pharm Bull 37:1505–1509

DOI

7
Huang M, Li M, Xiao F, Pang P, Liang J, Tang T, Liu S, Chen B, Shu J, You Y et al (2020) Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19. Natl Sci Rev 7:1428–1436

DOI

8
Qian M., Liu Z., Peng L., Tang X., Meng F., Ao Y., Zhou M., Wang M., Cao X., Qin B., et al. (2018). Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. eLife 7.

DOI

9
Sargiacomo C, Sotgia F, Lisanti MP (2020) COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection. Aging 12:6511–6517

DOI

10
Schrezenmeier E, Dorner T (2020) Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol 16:155–166

DOI

11
Shen H, Wu N, Wang Y, Zhao H, Zhang L, Li T, Zhao M (2017) Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis. Int Immunopharmacol 46:16–22

DOI

12
Solomon VR, Lee H (2009) Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 625:220–233

DOI

13
Wellems TE, Plowe CV (2001) Chloroquine-resistant malaria. J Infect Dis 184:770–776

DOI

14
Wozniacka A, Cygankiewicz I, Chudzik M, Sysa-Jedrzejowska A, Wranicz JK (2006) The cardiac safety of chloroquine phosphate treatment in patients with systemic lupus erythematosus: the influence on arrhythmia, heart rate variability and repolarization parameters. Lupus 15:521–525

DOI

15
Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P et al (2018) Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell 9:333–350

DOI

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