Low-dose chloroquine treatment extends the lifespan of aged rats
Published date: 15 Jun 2022
Copyright
Wei Li , Zhiran Zou , Yusheng Cai , Kuan Yang , Si Wang , Zunpeng Liu , Lingling Geng , Qun Chu , Zhejun Ji , Piu Chan , Guang-Hui Liu , Moshi Song , Jing Qu , Weiqi Zhang . Low-dose chloroquine treatment extends the lifespan of aged rats[J]. Protein & Cell, 2022 , 13(6) : 454 -461 . DOI: 10.1007/s13238-021-00903-1
1 |
Aging Atlas C (2021) Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Res 49:D825–D830
|
2 |
Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M et al (2020) SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell 11:483–504
|
3 |
Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L et al (2020) Elimination of senescent cells by beta-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res 30:574–589
|
4 |
Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS et al (2016) Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep 6:20101
|
5 |
Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L et al (2019) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10:417–435
|
6 |
He W, Wang B, Yang J, Zhuang Y, Wang L, Huang X, Chen J (2014) Chloroquine Improved Carbon Tetrachloride-Induced Liver Fibrosis through Its Inhibition of the Activation of Hepatic Stellate Cells: Role of Autophagy. Biol Pharm Bull 37:1505–1509
|
7 |
Huang M, Li M, Xiao F, Pang P, Liang J, Tang T, Liu S, Chen B, Shu J, You Y et al (2020) Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19. Natl Sci Rev 7:1428–1436
|
8 |
Qian M., Liu Z., Peng L., Tang X., Meng F., Ao Y., Zhou M., Wang M., Cao X., Qin B., et al. (2018). Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. eLife 7.
|
9 |
Sargiacomo C, Sotgia F, Lisanti MP (2020) COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection. Aging 12:6511–6517
|
10 |
Schrezenmeier E, Dorner T (2020) Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol 16:155–166
|
11 |
Shen H, Wu N, Wang Y, Zhao H, Zhang L, Li T, Zhao M (2017) Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis. Int Immunopharmacol 46:16–22
|
12 |
Solomon VR, Lee H (2009) Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 625:220–233
|
13 |
Wellems TE, Plowe CV (2001) Chloroquine-resistant malaria. J Infect Dis 184:770–776
|
14 |
Wozniacka A, Cygankiewicz I, Chudzik M, Sysa-Jedrzejowska A, Wranicz JK (2006) The cardiac safety of chloroquine phosphate treatment in patients with systemic lupus erythematosus: the influence on arrhythmia, heart rate variability and repolarization parameters. Lupus 15:521–525
|
15 |
Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P et al (2018) Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell 9:333–350
|
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