Low-dose chloroquine treatment extends the lifespan of aged rats

Wei Li; Zhiran Zou; Yusheng Cai; Kuan Yang; Si Wang; Zunpeng Liu; Lingling Geng; Qun Chu; Zhejun Ji; Piu Chan; Guang-Hui Liu; Moshi Song; Jing Qu; Weiqi Zhang

doi:10.1007/s13238-021-00903-1

Protein Cell ›› 2022, Vol. 13 ›› Issue (6) : 454 -461. DOI: 10.1007/s13238-021-00903-1

LETTER

Low-dose chloroquine treatment extends the lifespan of aged rats

Wei Li ¹^,⁸
, Zhiran Zou ²^,⁶^,⁷^,⁹
, Yusheng Cai ²^,⁶^,⁹
, Kuan Yang ⁴^,⁵^,⁷^,¹⁰^,¹¹
, Si Wang ¹^,⁸^,¹²
, Zunpeng Liu ³^,⁶^,⁷^,⁹
, Lingling Geng ¹^,⁸
, Qun Chu ³^,⁶^,⁹
, Zhejun Ji ³^,⁶^,⁹
, Piu Chan ⁸
, Guang-Hui Liu ¹^,²^,⁶^,⁷^,⁸^,⁹^,^†
, Moshi Song ²^,⁶^,⁷^,⁹^,^†
, Jing Qu ³^,⁶^,⁷^,⁹^,^†
, Weiqi Zhang ⁴^,⁵^,⁶^,⁷^,⁸^,¹⁰^,^†

Author information +

¹. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

². State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

³. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

⁴. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

⁵. China National Center for Bioinformation, Beijing 100101, China

⁶. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

⁷. University of Chinese Academy of Sciences, Beijing 100049, China

⁸. Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁹. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

¹⁰. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China

¹¹. Sino-Danish Center for Education and Research, Beijing 101408, China

¹². Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing 400062, China

ghliu@ioz.ac.cn

songmoshi@ioz.ac.cn

qujing@ioz.ac.cn

zhangwq@big.ac.cn

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Wei Li, Zhiran Zou, Yusheng Cai, Kuan Yang, Si Wang, Zunpeng Liu, Lingling Geng, Qun Chu, Zhejun Ji, Piu Chan, Guang-Hui Liu, Moshi Song, Jing Qu, Weiqi Zhang. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell, 2022, 13(6): 454-461 DOI:10.1007/s13238-021-00903-1

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