Protein & Cell >

2022 , Vol. 13 >Issue 8: 552 - 558

DOI: https://doi.org/10.1007/s13238-022-00907-5

POLICY FORUM

A framework for the responsible reform of the 14-day rule in human embryo research

  • Yaojin Peng , 1,2,3,4 ,
  • Jianwei Lv 1,2 ,
  • Zhenyu Xiao 1,2 ,
  • Lulu Ding 1,2 ,
  • Qi Zhou , 1,2,3
Expand
  • 1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 2. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 3. University of the Chinese Academy of Sciences, Beijing 100049, China
  • 4. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

Accepted date: 04 Jan 2022

Published date: 15 Aug 2022

Copyright

2022 The Author(s)
Fold

Cite this article

Yaojin Peng , Jianwei Lv , Zhenyu Xiao , Lulu Ding , Qi Zhou . A framework for the responsible reform of the 14-day rule in human embryo research[J]. Protein & Cell, 2022 , 13(8) : 552 -558 . DOI: 10.1007/s13238-022-00907-5

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Appleby JB , Bredenoord AL (2018) Should the 14-day rule for embryo research become the 28-day rule? EMBO Mol Med 10: e9437

DOI

2
Blackshaw BP , Rodger D (2021) Why we should not extend the 14-day rule. J Med Ethics 47: 712

DOI

3
Brown MT (2007) The potential of the human embryo. J Med Philos 32 (6): 585- 618

DOI

4
Chan S (2018) How and why to replace the 14-day rule. Curr Stem Cell Rep 4: 228- 234

DOI

5
Cuchiara ML , Davies JL , Matthews KRW (2013) Defining "research" in the US and EU:contrast of Sherley v. Sebelius and Brüstle v. Greenpeace rulings. Stem Cell Rev Rep 9 (6): 743- 751

DOI

6
Deglincerti A , Croft GF , Pietila LN , Zernicka-Goetz M , Siggia ED , Brivanlou AH (2016) Self-organization of the in vitro attached human embryo. Nature 533: 251- 254

DOI

7
Department of Health and Social Security (1984) Report of the committee of inquiry into human fertilisation and embryology, Her Majesty's Stationery Office, London

8
Doerflinger RM (1999) The ethics of funding embryonic stem cell research:a Catholic viewpoint. Kennedy Inst Ethics J 9 (2): 137- 150

DOI

9
Gu Z , Guo J , Wang H , Wen Y , Gu Q (2020) Bioengineered microenvironment to culture early embryos. Cell Prolif 53 (2): e12754

DOI

10
Hurlbut JB , Hyun I , Levine AD , Lovell-Badge R , Lunshof JE , Matthews KR , Mills P , Murdoch A , Pera MF , Scott CT et al (2017) Revisiting the Warnock rule. Nat Biotechnol 35: 1029- 1042

DOI

11
Hyun I , Wilkerson A , Johnston J (2016) Revisit the 14-day rule. Nature 533: 169- 171

DOI

12
Hyun I , Bredenoord AL , Briscoe J , Klipstein S , Tan T (2021) Human embryo research beyond the primitive streak:It is time to revisit the "14-day limit". Science 371 (6533): 998- 1000

DOI

13
International Society for Stem Cell Research (2021) Guidelines for stem cell research and clinical translation. https://www.isscr.org/policy/guidelines-for-stem-cell-research-and-clinical-translation

14
Li Z , Di J (2021) Foreword:prevention and control of birth defects in China:achievements and challenges. China CDC Weekly. http://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2021.191

15
Ma H , Zhai J , Wan H , Jiang X , Wang X , Wang L , Xiang Y , He X , Zhao ZA , Zhao B et al (2019) In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 366 (6467): eaax7890. https://doi.org/10.1126/science.aax7890

16
Matthews KR , Moralí D (2020) National human embryo and embryoid research policies:a survey of 22 top research-intensive countries. Regen Med 15 (7): 1905- 1917

DOI

17
McCully S (2021) The time has come to extend the 14-day limit. J Med Ethics 47: e66

DOI

18
Niu Y , Sun N , Li C , Lei Y , Huang Z , Wu J , Si C , Dai X , Liu C , Wei J et al (2019) Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 366 (6467): eaaw5754. https://doi.org/10.1126/science.aaw5754

19
Peng Y , Huang X , Zhou Qi (2020) Ethical and policy considerations for human embryo and stem cell research in China. Cell Stem Cell 27 (4): 511- 514

DOI

20
Poplawski N , Gillett G (1991) Ethics and embryos. J Med Ethics 17 (2): 62- 69

DOI

21
Regalado A (2021) Scientists plan to drop the 14-day embryo rule, a key limit on stem cell research. https://www.technologyreview.com/2021/03/16/1020879/scientists-14-day-limit-stem-cellhuman-embryo-research/

22
Reichlin M (1997) The argument from potential:a reappraisal. Bioethics 11 (1): 1- 23

DOI

23
Shahbazi MN , Jedrusik A , Vuoristo S , Recher G , Hupalowska A , Bolton V , Fogarty NNM , Campbell A , Devito L , Ilic D et al (2016) Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol 18: 700- 708

DOI

24
Sozen B , Jorgensen V , Weatherbee BAT , Chen S , Zhu M , Zernicka-Goetz M (2021) Reconstructing aspects of human embryogenesis with pluripotent stem cells. Nat Commun 12 (1): 5550

DOI

25
Wadman M (2021) United Kingdom moves to prevent birth defects. Science 374 (6567): 518- 519

DOI

26
Weatherbee BAT , Cui T , Zernicka-Goetz M (2021) Modeling human embryo development with embryonic and extra-embryonic stem cells. Dev Biol 474: 91- 99

DOI

27
Zhang JY (2012) The cosmopolitanization of science:stem cell governance in China, Palgrave Macmillan.

Options
Outlines

/

〈 〉