A framework for the responsible reform of the 14-day rule in human embryo research

Yaojin Peng , Jianwei Lv , Zhenyu Xiao , Lulu Ding , Qi Zhou

Protein Cell ›› 2022, Vol. 13 ›› Issue (8) : 552 -558.

PDF (416KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (8) : 552 -558. DOI: 10.1007/s13238-022-00907-5
POLICY FORUM
POLICY FORUM

A framework for the responsible reform of the 14-day rule in human embryo research

Author information +
History +
PDF (416KB)

Cite this article

Download citation ▾
Yaojin Peng, Jianwei Lv, Zhenyu Xiao, Lulu Ding, Qi Zhou. A framework for the responsible reform of the 14-day rule in human embryo research. Protein Cell, 2022, 13(8): 552-558 DOI:10.1007/s13238-022-00907-5

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Appleby JB , Bredenoord AL (2018) Should the 14-day rule for embryo research become the 28-day rule? EMBO Mol Med 10: e9437

[2]

Blackshaw BP , Rodger D (2021) Why we should not extend the 14-day rule. J Med Ethics 47: 712

[3]

Brown MT (2007) The potential of the human embryo. J Med Philos 32 (6): 585- 618

[4]

Chan S (2018) How and why to replace the 14-day rule. Curr Stem Cell Rep 4: 228- 234

[5]

Cuchiara ML , Davies JL , Matthews KRW (2013) Defining "research" in the US and EU:contrast of Sherley v. Sebelius and Brüstle v. Greenpeace rulings. Stem Cell Rev Rep 9 (6): 743- 751

[6]

Deglincerti A , Croft GF , Pietila LN , Zernicka-Goetz M , Siggia ED , Brivanlou AH (2016) Self-organization of the in vitro attached human embryo. Nature 533: 251- 254

[7]

Department of Health and Social Security (1984) Report of the committee of inquiry into human fertilisation and embryology, Her Majesty's Stationery Office, London

[8]

Doerflinger RM (1999) The ethics of funding embryonic stem cell research:a Catholic viewpoint. Kennedy Inst Ethics J 9 (2): 137- 150

[9]

Gu Z , Guo J , Wang H , Wen Y , Gu Q (2020) Bioengineered microenvironment to culture early embryos. Cell Prolif 53 (2): e12754

[10]

Hurlbut JB , Hyun I , Levine AD , Lovell-Badge R , Lunshof JE , Matthews KR , Mills P , Murdoch A , Pera MF , Scott CT et al (2017) Revisiting the Warnock rule. Nat Biotechnol 35: 1029- 1042

[11]

Hyun I , Wilkerson A , Johnston J (2016) Revisit the 14-day rule. Nature 533: 169- 171

[12]

Hyun I , Bredenoord AL , Briscoe J , Klipstein S , Tan T (2021) Human embryo research beyond the primitive streak:It is time to revisit the "14-day limit". Science 371 (6533): 998- 1000

[13]

International Society for Stem Cell Research (2021) Guidelines for stem cell research and clinical translation.

[14]

Li Z , Di J (2021) Foreword:prevention and control of birth defects in China:achievements and challenges. China CDC Weekly.

[15]

Ma H , Zhai J , Wan H , Jiang X , Wang X , Wang L , Xiang Y , He X , Zhao ZA , Zhao B et al (2019) In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 366 (6467): eaax7890.

[16]

Matthews KR , Moralí D (2020) National human embryo and embryoid research policies:a survey of 22 top research-intensive countries. Regen Med 15 (7): 1905- 1917

[17]

McCully S (2021) The time has come to extend the 14-day limit. J Med Ethics 47: e66

[18]

Niu Y , Sun N , Li C , Lei Y , Huang Z , Wu J , Si C , Dai X , Liu C , Wei J et al (2019) Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 366 (6467): eaaw5754.

[19]

Peng Y , Huang X , Zhou Qi (2020) Ethical and policy considerations for human embryo and stem cell research in China. Cell Stem Cell 27 (4): 511- 514

[20]

Poplawski N , Gillett G (1991) Ethics and embryos. J Med Ethics 17 (2): 62- 69

[21]

Regalado A (2021) Scientists plan to drop the 14-day embryo rule, a key limit on stem cell research.

[22]

Reichlin M (1997) The argument from potential:a reappraisal. Bioethics 11 (1): 1- 23

[23]

Shahbazi MN , Jedrusik A , Vuoristo S , Recher G , Hupalowska A , Bolton V , Fogarty NNM , Campbell A , Devito L , Ilic D et al (2016) Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol 18: 700- 708

[24]

Sozen B , Jorgensen V , Weatherbee BAT , Chen S , Zhu M , Zernicka-Goetz M (2021) Reconstructing aspects of human embryogenesis with pluripotent stem cells. Nat Commun 12 (1): 5550

[25]

Wadman M (2021) United Kingdom moves to prevent birth defects. Science 374 (6567): 518- 519

[26]

Weatherbee BAT , Cui T , Zernicka-Goetz M (2021) Modeling human embryo development with embryonic and extra-embryonic stem cells. Dev Biol 474: 91- 99

[27]

Zhang JY (2012) The cosmopolitanization of science:stem cell governance in China, Palgrave Macmillan.

RIGHTS & PERMISSIONS

The Author(s)

AI Summary AI Mindmap
PDF (416KB)

657

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/