LETTER

Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes

  • Beili Chen 1,5 ,
  • Jianying Guo 2,6 ,
  • Ting Wang 2,6 ,
  • Qianhui Lee 3 ,
  • Jia Ming 2 ,
  • Fangfang Ding 1,5 ,
  • Haitao Li 2,6 ,
  • Zhiguo Zhang , 1,5 ,
  • Lin Li , 4 ,
  • Yunxia Cao , 1,5 ,
  • Jie Na , 2
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  • 1. Department of Obstetrics and Gynecology, Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
  • 2. School of Medicine, Tsinghua University, Beijing 100084, China
  • 3. Department of Chemistry, Tsinghua University, Beijing 100084, China
  • 4. Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
  • 5. NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Medical University, Hefei 230032, China
  • 6. Tsinghua-Peking Center for Life Sciences, Beijing 100084, China

Accepted date: 23 Mar 2021

Published date: 15 Feb 2022

Copyright

2021 The Author(s)

Cite this article

Beili Chen , Jianying Guo , Ting Wang , Qianhui Lee , Jia Ming , Fangfang Ding , Haitao Li , Zhiguo Zhang , Lin Li , Yunxia Cao , Jie Na . Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes[J]. Protein & Cell, 2022 , 13(2) : 148 -154 . DOI: 10.1007/s13238-021-00844-9

1
Chen L, Chao SB, Wang ZB, Qi ST, Zhu XL, Yang SW, Yang CR, Zhang QH, Ouyang YC, Hou Y (2012) Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes. Cell Cycle 11:1948–1955

DOI

2
Eckersley-Maslin MA, Alda-Catalinas C, Reik W (2018) Dynamics of the epigenetic landscape during the maternal-to-zygotic transition. Nat Rev Mol Cell Biol 19:436–450

DOI

3
Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R (2017) Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinaseassociated 1 domain. Journal of Biological Chemistry 292:19024–19033

DOI

4
Goto H, Kasahara K, Inagaki M (2015) Novel Insights into Chk1 Regulation by Phosphorylation. Cell Structure and Function 40:43–50

DOI

5
Han XZ, Tang JS, Wang JN, Ren F, Zheng JH, Gragg M, Kiser P, Park PSH, Palczewski K, Yao XS (2016) Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. Journal of Biological Chemistry 291:12951–12959

DOI

6
Reichmann J, Nijmeijer B, Hossain MJ, Eguren M, Schneider I, Politi AZ, Roberti MJ, Hufnagel L, Hiiragi T, Ellenberg J (2018) Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos. Science 361:189–193

DOI

7
Reinhardt HC, Yaffe MB (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 21:245–255

DOI

8
Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133:864–877

DOI

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