Maternal heterozygous mutation in <i>CHEK1</i> leads to mitotic arrest in human zygotes

Beili Chen; Jianying Guo; Ting Wang; Qianhui Lee; Jia Ming; Fangfang Ding; Haitao Li; Zhiguo Zhang; Lin Li; Yunxia Cao; Jie Na

doi:10.1007/s13238-021-00844-9

PDF(1303 KB)

Protein Cell ›› 2022, Vol. 13 ›› Issue (2) : 148-154. DOI: 10.1007/s13238-021-00844-9

LETTER

Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes

Beili Chen¹^,⁵ ,
Jianying Guo²^,⁶ ,
Ting Wang²^,⁶ ,
Qianhui Lee³ ,
Jia Ming² ,
Fangfang Ding¹^,⁵ ,
Haitao Li²^,⁶ ,
Zhiguo Zhang¹^,⁵ ,
Lin Li⁴ ,
Yunxia Cao¹^,⁵ ,
Jie Na²

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Beili Chen, Jianying Guo, Ting Wang, Qianhui Lee, Jia Ming, Fangfang Ding, Haitao Li, Zhiguo Zhang, Lin Li, Yunxia Cao, Jie Na. Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes. Protein Cell, 2022, 13(2): 148‒154 https://doi.org/10.1007/s13238-021-00844-9

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Chen L, Chao SB, Wang ZB, Qi ST, Zhu XL, Yang SW, Yang CR, Zhang QH, Ouyang YC, Hou Y (2012) Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes. Cell Cycle 11:1948–1955 CrossRef Google scholar

[2]	Eckersley-Maslin MA, Alda-Catalinas C, Reik W (2018) Dynamics of the epigenetic landscape during the maternal-to-zygotic transition. Nat Rev Mol Cell Biol 19:436–450 CrossRef Google scholar

[3]	Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R (2017) Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinaseassociated 1 domain. Journal of Biological Chemistry 292:19024–19033 CrossRef Google scholar

[4]	Goto H, Kasahara K, Inagaki M (2015) Novel Insights into Chk1 Regulation by Phosphorylation. Cell Structure and Function 40:43–50 CrossRef Google scholar

[5]	Han XZ, Tang JS, Wang JN, Ren F, Zheng JH, Gragg M, Kiser P, Park PSH, Palczewski K, Yao XS (2016) Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. Journal of Biological Chemistry 291:12951–12959 CrossRef Google scholar

[6]	Reichmann J, Nijmeijer B, Hossain MJ, Eguren M, Schneider I, Politi AZ, Roberti MJ, Hufnagel L, Hiiragi T, Ellenberg J (2018) Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos. Science 361:189–193 CrossRef Google scholar

[7]	Reinhardt HC, Yaffe MB (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 21:245–255 CrossRef Google scholar

[8]	Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133:864–877 CrossRef Google scholar