Protein & Cell >

2021 , Vol. 12 >Issue 9: 741 - 745

DOI: https://doi.org/10.1007/s13238-021-00824-z

LETTER

Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos

  • Yu Wei 1,2 ,
  • Yingsi Zhou 1 ,
  • Yajing Liu 1 ,
  • Wenqin Ying 1 ,
  • Ruiming Lv 1 ,
  • Qimeng Zhao 1,2 ,
  • Haibo Zhou 1,3 ,
  • Erwei Zuo , 4 ,
  • Yidi Sun , 1 ,
  • Hui Yang , 1,3 ,
  • Changyang Zhou , 1
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  • 1. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
  • 2. University of Chinese Academy of Sciences, Beijing 100049, China
  • 3. Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China
  • 4. Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China

Accepted date: 12 Jan 2021

Published date: 15 Sep 2021

Copyright

2021 The Author(s)
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Cite this article

Yu Wei , Yingsi Zhou , Yajing Liu , Wenqin Ying , Ruiming Lv , Qimeng Zhao , Haibo Zhou , Erwei Zuo , Yidi Sun , Hui Yang , Changyang Zhou . Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos[J]. Protein & Cell, 2021 , 12(9) : 741 -745 . DOI: 10.1007/s13238-021-00824-z

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