Protein & Cell >

2021 , Vol. 12 >Issue 9: 734 - 740

DOI: https://doi.org/10.1007/s13238-021-00832-z

LETTER

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

  • Dan Zhao 1 ,
  • Weifan Xu 2,3 ,
  • Xiaofan Zhang 1 ,
  • Xiaoting Wang 4 ,
  • Yiyue Ge 5 ,
  • Enming Yuan 1 ,
  • Yuanpeng Xiong 6 ,
  • Shenyang Wu 7 ,
  • Shuya Li 1 ,
  • Nian Wu 1 ,
  • Tingzhong Tian 1 ,
  • Xiaolong Feng 8 ,
  • Hantao Shu 1 ,
  • Peng Lang 1 ,
  • Jingxin Li 5 ,
  • Fengcai Zhu 5,9 ,
  • Xiaokun Shen 10 ,
  • Haitao Li 3,11 ,
  • Pilong Li , 2,3 ,
  • Jianyang Zeng , 1
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  • 1. Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China
  • 2. Beijing Advanced Innovation Center for Structural Biology Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China
  • 3. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China
  • 4. Silexon AI Technology Co., Ltd, Nanjing 210033, China
  • 5. NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing 210009, China
  • 6. Bioinformatics Division, BNRIST/Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
  • 7. Protein Preparation and Identification Facility, Technology Center for Protein Science, Tsinghua University, Beijing 100084, China
  • 8. Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
  • 9. Center for Global Health, Nanjing Medical University, Nanjing 210009, China
  • 10. Convalife (Shanghai) Co., Ltd, Shanghai 201203, China
  • 11. Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

Accepted date: 27 Jan 2021

Published date: 15 Sep 2021

Copyright

2021 The Author(s)
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Cite this article

Dan Zhao , Weifan Xu , Xiaofan Zhang , Xiaoting Wang , Yiyue Ge , Enming Yuan , Yuanpeng Xiong , Shenyang Wu , Shuya Li , Nian Wu , Tingzhong Tian , Xiaolong Feng , Hantao Shu , Peng Lang , Jingxin Li , Fengcai Zhu , Xiaokun Shen , Haitao Li , Pilong Li , Jianyang Zeng . Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2[J]. Protein & Cell, 2021 , 12(9) : 734 -740 . DOI: 10.1007/s13238-021-00832-z

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