COMMENTARY

Tongue as a first-line immune organ?

  • Jane Y. Wu
Expand
  • Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, USA

Received date: 27 Oct 2020

Published date: 15 Mar 2021

Copyright

2021 The Author(s)

Cite this article

Jane Y. Wu . Tongue as a first-line immune organ?[J]. Protein & Cell, 2021 , 12(3) : 162 -164 . DOI: 10.1007/s13238-020-00802-x

1
Camandola S, Mattson MP (2017) Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation. Obesity 25(7):1237–1245

DOI

2
Cao X (2020) COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. https://doi.org/10.1038/s41577-020-0308-3

DOI

3
Carey RM, Lee RJ (2019) Taste receptors in upper airway innate immunity. Nutrients 11(9):2017

DOI

4
Cuburu N, Kweon MN, Song JH, Hervouet C, Luci C, Sun JB, Hofman P, Holmgren J, Anjuère F, Czerkinsky C (2007) Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 25(51):8598–8610

DOI

5
Czerkinsky C, Cuburu N, Kweon MN, Anjuere F, Holmgren J (2011) Sublingual vaccination. Hum Vaccin 7(1):110–114

DOI

6
Freund JR, Mansfield CJ, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Reed DR, Jiang P, Lee RJ (2018) Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling. J Biol Chem 293(25):9824–9840

DOI

7
Gondak RO, Alves DB, Silva LF, Mauad T, Vargas PA (2012) Depletion of Langerhans cells in the tongue from patients with advanced-stage acquired immune deficiency syndrome: relation to opportunistic infections. Histopathology 60(3):497–503

DOI

8
Grassin-Delyle S, Salvator H, Mantov N, Abrial C, Brollo M, Faisy C, Naline E, Couderc LJ, Devillier P (2019) Bitter taste receptors (TAS2Rs) in human lung macrophages: receptor expression and inhibitory effects of TAS2R agonists. Front Physiol 10:1267

DOI

9
Iemoli E, Borgonovo L, Fusi A, Magni C, Ricci ED, Rizzardini G, Piconi S (2016) Sublingual allergen immunotherapy in HIVpositive patients. Allergy 71(3):412–415

DOI

10
Jones AT, Shen X, Walter KL, LaBranche CC, Wyatt LS, Tomaras GD, Montefiori DC, Moss B, Barouch DH, Clements JD (2019) HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge. Nat Commun 10(1):798

DOI

11
Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D (2015) Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol 97:533–545

DOI

12
McCluskie MJ, Brazolot Millan CL, Gramzinski RA, Robinson HL, Santoro JC, Fuller JT, Widera G, Haynes JR, Purcell RH, Davis HL (1999) Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol Med 5(5):287–300

DOI

13
Orsmark-Pietras C, James A, Konradsen JR, Nordlund B, Soderhall C, Pulkkinen V, Daham K, Kupczyk M, Dahlén B, Kere J (2013) Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur Respir J 42:65–78

DOI

14
Park A, Iwasaki A (2020) Type I and Type III interferons—induction, signaling, evasion, and application to combat COVID-19. Cell Host Microbe 27(6):870–878

DOI

15
Roper SD, Chaudhari N (2017) Taste buds: cells, signals and synapses. Nat Rev Neurosci 18(8):485–497

DOI

16
Scheiblhofer S, Thalhamer J, Weiss R (2018) DNA and mRNA vaccination against allergies. Pediatr Allergy Immunol 29(7):679–688

DOI

17
Shaikh N, Rivera J, Hewlett BR, Stead RH, Zhu FG, Marshall JS (1997) Mast cell Fc epsilonRI expression in the rat intestinal mucosa and tongue is enhanced during Nippostrongylus brasiliensis infection and can be up-regulated by in vivo administration of IgE. J Immunol 158(8):3805–3812

18
Thirion-Delalande C, Gervais F, Fisch C, Cuiné J, Baron-Bodo V, Moingeon P, Mascarell L (2017) Comparative analysis of the oral mucosae from rodents and non-rodents: application to the nonclinical evaluation of sublingual immunotherapy products. PLoS ONE 12(9):e0183398

DOI

Outlines

/