Protein & Cell >

2021 , Vol. 12 >Issue 8: 661 - 666

DOI: https://doi.org/10.1007/s13238-020-00808-5

LETTER

Structural insights into the activation initiation of full-length mGlu1

  • Jinyi Zhang 1,2,3,4 ,
  • Lu Qu 1 ,
  • Lijie Wu 1 ,
  • Xiaomeng Tang 1 ,
  • Feng Luo 1 ,
  • Weixiu Xu 1,2,3 ,
  • Yueming Xu 1 ,
  • Zhi-Jie Liu , 1,2 ,
  • Tian Hua , 1,2
Expand
  • 1. iHuman Institute, ShanghaiTech University, Shanghai 201210, China
  • 2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
  • 3. University of Chinese Academy of Sciences, Beijing 100049, China
  • 4. CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China

Accepted date: 10 Nov 2020

Published date: 15 Aug 2021

Copyright

2020 The Author(s) 2020
Fold

Cite this article

Jinyi Zhang , Lu Qu , Lijie Wu , Xiaomeng Tang , Feng Luo , Weixiu Xu , Yueming Xu , Zhi-Jie Liu , Tian Hua . Structural insights into the activation initiation of full-length mGlu1[J]. Protein & Cell, 2021 , 12(8) : 661 -666 . DOI: 10.1007/s13238-020-00808-5

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Bessis AS, Rondard P, Gaven F, Brabet I, Triballeau N, Prezeau L, Acher F, Pin JP (2002) Closure of the Venus flytrap module of mGlu8 receptor and the activation process: insights from mutations converting antagonists into agonists. Proc Natl Acad Sci USA 99:11097–11102

DOI

2
Doumazane E, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P (2013) Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. Proc Natl Acad Sci USA 110:E1416–1425

DOI

3
Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P (2011) Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci USA 108:15480–15485

DOI

4
Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci USA 98:13402–13407

DOI

5
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J (2019) Structural insights into the activation of metabotropic glutamate receptors. Nature 566:79–84

DOI

6
Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407:971–977

DOI

7
Muto T, Tsuchiya D, Morikawa K, Jingami H (2007) Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc Natl Acad Sci USA 104:3759–3764

DOI

8
Nakanishi S, Masu M (1994) Molecular diversity and functions of glutamate receptors. Annu Rev Biophys Biomol Struct 23:319–348

DOI

9
Pin JP, Bettler B (2016) Organization and functions of mGlu and GABAB receptor complexes. Nature 540:60–68

DOI

10
Scheefhals N, MacGillavry HD (2018) Functional organization of postsynaptic glutamate receptors. Mol Cell Neurosci 91:82–94

DOI

11
Schoepp DD, Jane DE, Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431–1476

DOI

12
Stansley BJ, Conn PJ (2019) Neuropharmacological insight from allosteric modulation of mGlu receptors. Trends Pharmacol Sci 40:240–252

DOI

13
Tateyama M, Abe H, Nakata H, Saito O, Kubo Y (2004) Ligandinduced rearrangement of the dimeric metabotropic glutamate receptor 1alpha. Nat Struct Mol Biol 11:637–642

DOI

14
Tsuchiya D, Kunishima N, Kamiya N, Jingami H, Morikawa K (2002) Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc Natl Acad Sci USA 99:2660–2665

DOI

15
Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V (2014) Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science 344:58–64

DOI

Options
Outlines

/

〈 〉