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O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis

  • Fan Yu 1 ,
  • Te Li 1 ,
  • Yanchao Sui 2 ,
  • Qingxia Chen 3,4 ,
  • Song Yang 1 ,
  • Jia Yang 1 ,
  • Renjie Hong 1 ,
  • Dengwen Li 1 ,
  • Xiumin Yan 3,4 ,
  • Wei Zhao 2 ,
  • Xueliang Zhu 3,4 ,
  • Jun Zhou , 1,5
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  • 1. Department of Genetics and Cell Biology, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, Key Laboratory of Bioactive Materials of the Ministry of Education, Nankai University, Tianjin 300071, China
  • 2. College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
  • 3. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China
  • 4. University of Chinese Academy of Sciences, Beijing 100049, China
  • 5. Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China

Published date: 15 Nov 2020

Copyright

2020 The Author(s)

Cite this article

Fan Yu , Te Li , Yanchao Sui , Qingxia Chen , Song Yang , Jia Yang , Renjie Hong , Dengwen Li , Xiumin Yan , Wei Zhao , Xueliang Zhu , Jun Zhou . O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis[J]. Protein & Cell, 2020 , 11(11) : 852 -857 . DOI: 10.1007/s13238-020-00746-2

1
Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820

DOI

2
Hardiville S, Hart GW (2014) Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation. Cell Metab 20:208–213

DOI

3
Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S (2011) A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol 8:72–77

DOI

4
Jinek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E (2004) The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol 11:1001–1007

DOI

5
Marquardt JR, Perkins JL, Beuoy KJ, Fisk HA (2016) Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore. Proc Natl Acad Sci USA 113:7828–7833

DOI

6
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y (2020) ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev Cell 53(287–299):e285

DOI

7
Schou KB, Morthorst SK, Christensen ST, Pedersen LB (2014) Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8. Cilia 3:6

DOI

8
Tang Z, Lin MG, Stowe TR, Chen S, Zhu M, Stearns T, Franco B, Zhong Q (2013) Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 502:254–257

DOI

9
Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (1995) CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81:261–268

DOI

10
Yang X, Qian K (2017) Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol 18:452–465

DOI

11
Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R (2014) CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res 24:1342–1353

DOI

12
Yang Y, Hao H, Wu X, Guo S, Liu Y, Ran J, Li T, Li D, Liu M, Zhou J (2019) Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport. Cell Discov 5:33

DOI

13
Yu F, Ran J, Zhou J (2016) Ciliopathies: does hdac6 represent a new therapeutic target? Trends Pharmacol Sci 37:114–119

DOI

14
Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X (2019) Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res 29:171–173

DOI

15
Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X, Zhu X (2013) The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol 15:1434

DOI

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