Protein & Cell >

2020 , Vol. 11 >Issue 6: 446 - 451

DOI: https://doi.org/10.1007/s13238-020-00725-7

LETTER

Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

  • Meng Gao 1,2,3 ,
  • Jian Huang 1,2,3 ,
  • Xin Jiang 2,3,4,5 ,
  • Yafei Yuan 2,3,4 ,
  • Huanhuan Pang 6 ,
  • Shuchen Luo 1,2,3 ,
  • Nan Wang 2,3,4 ,
  • Chengbo Yao 1,2,3 ,
  • Zuwan Lin 1,2,3 ,
  • Debing Pu 2,3,6 ,
  • Shuo Zhang 2,3,4 ,
  • Pengcheng Sun 2,3,4 ,
  • Zhuoyi Liu 1,2,3 ,
  • Yu Xiao 7 ,
  • Qian Wang 7 ,
  • Zeping Hu 6 ,
  • Hang Yin , 2,3,6
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  • 1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
  • 2. Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China
  • 3. Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China
  • 4. State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
  • 5. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
  • 6. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China
  • 7. Laboratory Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Published date: 15 Jun 2020

Copyright

2020 The Author(s) 2020
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Cite this article

Meng Gao , Jian Huang , Xin Jiang , Yafei Yuan , Huanhuan Pang , Shuchen Luo , Nan Wang , Chengbo Yao , Zuwan Lin , Debing Pu , Shuo Zhang , Pengcheng Sun , Zhuoyi Liu , Yu Xiao , Qian Wang , Zeping Hu , Hang Yin . Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters[J]. Protein & Cell, 2020 , 11(6) : 446 -451 . DOI: 10.1007/s13238-020-00725-7

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Scholmerich J, Oefner PJ (2009) GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 174:1544–1552

DOI

2
DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:18

DOI

3
Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE (1998) GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 83:34–40

DOI

4
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

DOI

5
Katt WP, Lukey MJ, Cerione RA (2019) Starving the devourer: cutting cancer off from its favorite foods. Cell Chem Biol 26:1197–1199

DOI

6
Kim SW, Lee JH, Moon JH, Nazim UMD, Lee YJ, Seol JW, Hur J, Eo SK, Lee JH, Park SY (2016) Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation. Oncotarget 7:4356–4368

DOI

7
Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A, Brys M (2012) Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res 18:721–728

DOI

8
Kurata T, Oguri T, Isobe T, Ishioka S, Yamakido M (1999) Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn J Cancer Res 90:1238–1243

DOI

9
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang ZB, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24:213–228

DOI

10
Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23:27–47

DOI

11
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033

DOI

12
Wang XX, Yang KL, Xie Q, Wu QL, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu XJ (2017) Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nat Neurosci 20:661–673

DOI

13
Wang ZX, Yip LY, Lee JHJ, Wu ZW, Chew HY, Chong PKW, Teo CC, Ang HYK, Peh KLE, Yuan J (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25:825–837

DOI

14
Warburg O (1956) On the origin of cancer cells. Science 123:309–314

DOI

15
Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT (1997) Overexpression of GLUT1 and GLUT3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 80:1046–1051

DOI

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