Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

Meng Gao , Jian Huang , Xin Jiang , Yafei Yuan , Huanhuan Pang , Shuchen Luo , Nan Wang , Chengbo Yao , Zuwan Lin , Debing Pu , Shuo Zhang , Pengcheng Sun , Zhuoyi Liu , Yu Xiao , Qian Wang , Zeping Hu , Hang Yin

Protein Cell ›› 2020, Vol. 11 ›› Issue (6) : 446 -451.

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Protein Cell ›› 2020, Vol. 11 ›› Issue (6) : 446 -451. DOI: 10.1007/s13238-020-00725-7
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Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

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Meng Gao, Jian Huang, Xin Jiang, Yafei Yuan, Huanhuan Pang, Shuchen Luo, Nan Wang, Chengbo Yao, Zuwan Lin, Debing Pu, Shuo Zhang, Pengcheng Sun, Zhuoyi Liu, Yu Xiao, Qian Wang, Zeping Hu, Hang Yin. Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters. Protein Cell, 2020, 11(6): 446-451 DOI:10.1007/s13238-020-00725-7

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References

[1]

Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Scholmerich J, Oefner PJ (2009) GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 174:1544–1552

[2]

DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:18

[3]

Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE (1998) GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 83:34–40

[4]

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

[5]

Katt WP, Lukey MJ, Cerione RA (2019) Starving the devourer: cutting cancer off from its favorite foods. Cell Chem Biol 26:1197–1199

[6]

Kim SW, Lee JH, Moon JH, Nazim UMD, Lee YJ, Seol JW, Hur J, Eo SK, Lee JH, Park SY (2016) Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation. Oncotarget 7:4356–4368

[7]

Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A, Brys M (2012) Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res 18:721–728

[8]

Kurata T, Oguri T, Isobe T, Ishioka S, Yamakido M (1999) Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn J Cancer Res 90:1238–1243

[9]

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang ZB, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24:213–228

[10]

Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23:27–47

[11]

Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033

[12]

Wang XX, Yang KL, Xie Q, Wu QL, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu XJ (2017) Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nat Neurosci 20:661–673

[13]

Wang ZX, Yip LY, Lee JHJ, Wu ZW, Chew HY, Chong PKW, Teo CC, Ang HYK, Peh KLE, Yuan J (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25:825–837

[14]

Warburg O (1956) On the origin of cancer cells. Science 123:309–314

[15]

Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT (1997) Overexpression of GLUT1 and GLUT3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 80:1046–1051

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