Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

Meng Gao; Jian Huang; Xin Jiang; Yafei Yuan; Huanhuan Pang; Shuchen Luo; Nan Wang; Chengbo Yao; Zuwan Lin; Debing Pu; Shuo Zhang; Pengcheng Sun; Zhuoyi Liu; Yu Xiao; Qian Wang; Zeping Hu; Hang Yin

doi:10.1007/s13238-020-00725-7

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Protein Cell ›› 2020, Vol. 11 ›› Issue (6) : 446-451. DOI: 10.1007/s13238-020-00725-7

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Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

Meng Gao¹^,²^,³ ,
Jian Huang¹^,²^,³ ,
Xin Jiang²^,³^,⁴^,⁵ ,
Yafei Yuan²^,³^,⁴ ,
Huanhuan Pang⁶ ,
Shuchen Luo¹^,²^,³ ,
Nan Wang²^,³^,⁴ ,
Chengbo Yao¹^,²^,³ ,
Zuwan Lin¹^,²^,³ ,
Debing Pu²^,³^,⁶ ,
Shuo Zhang²^,³^,⁴ ,
Pengcheng Sun²^,³^,⁴ ,
Zhuoyi Liu¹^,²^,³ ,
Yu Xiao⁷ ,
Qian Wang⁷ ,
Zeping Hu⁶ ,
Hang Yin²^,³^,⁶

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Meng Gao, Jian Huang, Xin Jiang, Yafei Yuan, Huanhuan Pang, Shuchen Luo, Nan Wang, Chengbo Yao, Zuwan Lin, Debing Pu, Shuo Zhang, Pengcheng Sun, Zhuoyi Liu, Yu Xiao, Qian Wang, Zeping Hu, Hang Yin. Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters. Protein Cell, 2020, 11(6): 446‒451 https://doi.org/10.1007/s13238-020-00725-7

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Scholmerich J, Oefner PJ (2009) GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 174:1544–1552 CrossRef Google scholar

[2]	DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:18 CrossRef Google scholar

[3]	Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE (1998) GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 83:34–40 CrossRef Google scholar

[4]	Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674 CrossRef Google scholar

[5]	Katt WP, Lukey MJ, Cerione RA (2019) Starving the devourer: cutting cancer off from its favorite foods. Cell Chem Biol 26:1197–1199 CrossRef Google scholar

[6]	Kim SW, Lee JH, Moon JH, Nazim UMD, Lee YJ, Seol JW, Hur J, Eo SK, Lee JH, Park SY (2016) Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation. Oncotarget 7:4356–4368 CrossRef Google scholar

[7]	Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A, Brys M (2012) Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res 18:721–728 CrossRef Google scholar

[8]	Kurata T, Oguri T, Isobe T, Ishioka S, Yamakido M (1999) Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn J Cancer Res 90:1238–1243 CrossRef Google scholar

[9]	Patra KC, Wang Q, Bhaskar PT, Miller L, Wang ZB, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24:213–228 CrossRef Google scholar

[10]	Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23:27–47 CrossRef Google scholar

[11]	Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033 CrossRef Google scholar

[12]	Wang XX, Yang KL, Xie Q, Wu QL, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu XJ (2017) Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nat Neurosci 20:661–673 CrossRef Google scholar

[13]	Wang ZX, Yip LY, Lee JHJ, Wu ZW, Chew HY, Chong PKW, Teo CC, Ang HYK, Peh KLE, Yuan J (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25:825–837 CrossRef Google scholar

[14]	Warburg O (1956) On the origin of cancer cells. Science 123:309–314 CrossRef Google scholar

[15]	Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT (1997) Overexpression of GLUT1 and GLUT3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 80:1046–1051 CrossRef Google scholar