COMMENTARY

Seven facts and five initiatives for gut microbiome research

  • Danyi Li 1 ,
  • Chunhui Gao 1 ,
  • Faming Zhang 2,3,4 ,
  • Ruifu Yang 5 ,
  • Canhui Lan 1 ,
  • Yonghui Ma , 6 ,
  • Jun Wang , 7
Expand
  • 1. Beijing Rexinchang Biotechnology Research Institute Co. Ltd, Beijing 100011, China
  • 2. Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
  • 3. Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 210011, China
  • 4. Division of Microbiotherapy, Sir Run Run Shaw Hospital, Nanjing Medical University, Nanjing 211166, China
  • 5. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
  • 6. Centre for Bioethics, Medical College, Xiamen University, Xiamen 361102, China
  • 7. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China

Published date: 15 Jun 2020

Copyright

2020 The Author(s)

Cite this article

Danyi Li , Chunhui Gao , Faming Zhang , Ruifu Yang , Canhui Lan , Yonghui Ma , Jun Wang . Seven facts and five initiatives for gut microbiome research[J]. Protein & Cell, 2020 , 11(6) : 391 -400 . DOI: 10.1007/s13238-020-00697-8

1
Aagaard K, Hohmann E (2019) Regulating microbiome manipulation. Nat Med 25(6):874–876

DOI

2
Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 15 (12):1257–1272

DOI

3
Avetisyan M, Schill EM, Heuckeroth RO (2015) Building a second brain in the bowel. J Clin Invest 125(3):899–907

DOI

4
Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H (2019) Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2019.1411

DOI

5
Barnard ND, Willett WC, Ding EL (2017) The misuse of metaanalysis in nutrition research. JAMA 318(15):1435–1436

DOI

6
Belkaid Y, Harrison OJ (2017) Homeostatic immunity and the microbiota. Immunity 46(4):562–576

DOI

7
Bothwell LE, Podolsky SH (2016) The emergence of the randomized, controlled trial. N Engl J Med 375(6):501–504

DOI

8
Bunyavanich S (2019) Food allergy: could the gut microbiota hold the key? Nat Rev Gastroenterol Hepatol 16(4):201–202

DOI

9
Byndloss MX, Bäumler AJ (2018) The germ-organ theory of noncommunicable diseases. Nat Rev Microbiol 16(2):103–110

DOI

10
Canfora EE, Meex RCR, Venema K, Blaak EE (2019) Gut microbial metabolites in obesity, NAFLD and T2DM. Nat Rev Endocrinol 15 (5):261–273

DOI

11
Chatterjee S, Khunti K, Davies MJ (2017) Type 2 diabetes. Lancet Lond Engl 389(10085):2239–2251

DOI

12
Clemente JC, Ursell LK, Parfrey LW, Knight R (2012) The impact of the gut microbiota on human health: an integrative view. Cell 148 (6):1258–1270

DOI

13
Clemente JC, Manasson J, Scher JU (2018) The role of the gut microbiome in systemic inflammatory disease. BMJ 360:j5145

DOI

14
Cohen PA (2018) Probiotic safety-no guarantees. JAMA Intern Med 178(12):1577–1578

DOI

15
Costea PI, Zeller G, Sunagawa S, Pelletier E, Alberti A, Levenez F, Tramontano M, Driessen M, Hercog R, Jung F-E (2017) Towards standards for human fecal sample processing in metagenomic studies. Nat Biotechnol 35(11):1069–1076

DOI

16
Crow D (2018) Microbiome research in a social world. Cell 172 (6):1143–1145

DOI

17
Cryan JF, O’Riordan KJ, Sandhu K, Peterson V, Dinan TG (2020) The gut microbiome in neurological disorders. Lancet Neurol 19 (2):179–194

DOI

18
Dalile B, Van Oudenhove L, Vervliet B, Verbeke K (2019) The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol 16(8):461–478

DOI

19
Dauby N (2017) Risks of Saccharomyces boulardii-containing probiotics for the prevention of clostridium difficile infection in the elderly. Gastroenterology 153(5):1450–1451

DOI

20
DeFilipp Z, Bloom PP, Torres Soto M, Mansour MK, Sater MRA, Huntley MH, Turbett S, Chung RT, Chen Y-B, Hohmann EL (2019) Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant. N Engl J Med 381(21):2043–2050

DOI

21
Djulbegovic B, Guyatt GH (2017) Progress in evidence-based medicine: a quarter century on. Lancet Lond Engl 390 (10092):415–423

DOI

22
Dominguez-Bello MG, Peterson D, Noya-Alarcon O, Bevilacqua M, Rojas N, Rodríguez R, Pinto SA, Baallow R, Caballero-Arias H (2016) Ethics of exploring the microbiome of native peoples. Nat Microbiol 1(7):16097

DOI

23
Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M(2019) Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature 575(7783):505–511

DOI

24
Fischbach MA (2018) Microbiome: focus on causation and mechanism. Cell 174(4):785–790

DOI

25
Ford AC, Lacy BE, Talley NJ (2017) Irritable bowel syndrome. N Engl J Med 376(26):2566–2578

DOI

26
Franks PW, McCarthy MI (2016) Exposing the exposures responsible for type 2 diabetes and obesity. Science 354(6308):69–73

DOI

27
Galea S, Saitz R (2017) Funding, institutional conflicts of interest, and schools of public health: realities and solutions. JAMA 317 (17):1735–1736

DOI

28
Garrett WS (2015) Cancer and the microbiota. Science 348 (6230):80–86

DOI

29
Gehrig JL, Venkatesh S, Chang H-W, Hibberd MC, Kung VL, Cheng J,Chen RY, Subramanian S, Cowardin CA, Meier MF (2019) Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science 365(6449):eaau4732

DOI

30
Gentile CL, Weir TL (2018) The gut microbiota at the intersection of diet and human health. Science 362(6416):776–780

DOI

31
Gilbert JA, Quinn RA, Debelius J,Xu ZZ, Morton J, Garg N, Jansson JK, Dorrestein PC, Knight R (2016) Microbiome-wide association studies link dynamic microbial consortia to disease. Nature 535 (7610):94–103

DOI

32
Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R (2018) Current understanding of the human microbiome. Nat Med 24(4):392–400

DOI

33
Goldszmid RS, Trinchieri G (2012) The price of immunity. Nat Immunol 13(10):932–938

DOI

34
Green JM, Barratt MJ, Kinch M, Gordon JI (2017) Food and microbiota in the FDA regulatory framework. Science 357 (6346):39–40

DOI

35
Greenhalgh S (2019) Making China safe for coke: how Coca-Cola shaped obesity science and policy in China. BMJ 364:k5050

DOI

36
Gribble FM, Reimann F (2019) Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol 15(4):226–237

DOI

37
Guarino A, Canani RB (2016) Probiotics in childhood diseases: from basic science to guidelines in 20 years of research and development. J Pediatr Gastroenterol Nutr 63(Suppl 1):S1–S2

38
Hall AB, Tolonen AC, Xavier RJ (2017) Human genetic variation and the gut microbiome in disease. Nat Rev Genet 18(11):690–699

DOI

39
Hanage WP (2014) Microbiology: microbiome science needs a healthy dose of scepticism. Nature 512(7514):247–248

DOI

40
Hoffmann D, Palumbo F, Ravel J, Roghmann M-C, Rowthorn V, von Rosenvinge E (2017) Improving regulation of microbiota transplants . Science 358(6369):1390–1391

DOI

41
Hughes HK, Landa MM, Sharfstein JM (2017) Marketing claims for infant formula: the need for evidence. JAMA Pediatr 171(2):105–106

DOI

42
Inamo J (2019) Non-causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study. Ann Rheum Dis.https://doi.org/10.1136/annrheumdis-2019-216565

DOI

43
Isabella VM, Ha BN, Castillo MJ, Lubkowicz DJ, Rowe SE, Millet YA, Anderson CL, Li N, Fisher AB, West KA (2018) Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat Biotechnol 36(9):857–864

DOI

44
Iweala OI, Nagler CR (2019) The microbiome and food allergy. Annu Rev Immunol 37:377–403

DOI

45
Jia J, Dou P, Gao M, Kong X, Li C, Liu Z, Huang T (2019) Assessment of causal direction between gut microbiota-dependent metabolites and cardiometabolic health: a bidirectional mendelian randomization analysis. Diabetes 68(9):1747–1755

DOI

46
Johnson AJ, Vangay P, Al-Ghalith GA,Hillmann BM, Ward TL, Shields-Cutler RR, Kim AD, Shmagel AK, Syed AN, Personalized Microbiome Class Students (2019) Daily sampling reveals personalized diet-microbiome associations in humans. Cell Host Microbe 25(6):789–802.e5

DOI

47
Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR (2006) Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes 2005 30(11):1585–1594

DOI

48
Kivipelto M, Mangialasche F, Ngandu T (2018) Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol 14(11):653–666

DOI

49
Kleerebezem M, Binda S, Bron PA, Gross G, Hill C, van Hylckama Vlieg JE, Lebeer S, Satokari R, Ouwehand AC (2019) Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics. Curr Opin Biotechnol 56:55–60

DOI

50
Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J,Gonzalez A, Kosciolek T,McCall L-I, McDonald D(2018) Best practices for analysing microbiomes. Nat Rev Microbiol 16 (7):410–422

DOI

51
Komaroff AL (2017) The microbiome and risk for obesity and diabetes. JAMA 317(4):355–356

DOI

52
Lagier J-C, Dubourg G, Million M, Cadoret F, Bilen M, Fenollar F, Levasseur A, Rolain J-M, Fournier P-E,Raoult D (2018) Culturing the human microbiota and culturomics. Nat Rev Microbiol 16 (9):540–550

DOI

53
Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto J-M,Kennedy S (2013) Richness of human gut microbiome correlates with metabolic markers. Nature 500(7464):541–546

DOI

54
Levin ME, Botha M, Basera W,Facey-Thomas HE, Gaunt B, Gray CL, Kiragu W, Ramjith J, Watkins A, Genuneit J (2020) Environmental factors associated with allergy in urban and rural children from the South AFrican Food Allergy (SAFFA) cohort. J Allergy Clin Immunol 145(1):415–426

DOI

55
Lloyd-Price J, Abu-Ali G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8(1):51

DOI

56
Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375(24):2369–2379

DOI

57
Manfredo Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T,Ruff W (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359(6380):1156–1161

DOI

58
Mayer EA (2011) Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 12(8):453–466

DOI

59
Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557(7706):580–584

DOI

60
Miller V,Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, Dagenais G,Gupta R, Mohan V, Lear S (2017) Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study. Lancet Lond Engl 390(10107):2037–2049

DOI

61
Mitselou N, Hallberg J, Stephansson O, Almqvist C, Melén E,Ludvigsson JF (2018) Cesarean delivery, preterm birth, and risk of food allergy: nationwide Swedish cohort study of more than 1 million children. J Allergy Clin Immunol 142(5):1510–1514.e2

DOI

62
Mozaffarian D (2017) Conflict of interest and the role of the food industry in nutrition research. JAMA 317(17):1755–1756

DOI

63
Nayfach S, Shi ZJ, Seshadri R, Pollard KS, Kyrpides NC (2019) New insights from uncultivated genomes of the global human gut microbiome. Nature 568(7753):505–510

DOI

64
Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S (2012) Host-gut microbiota metabolic interactions. Science 336(6086):1262–1267

DOI

65
NIH Human Microbiome Portfolio Analysis Team (2019) A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007–2016. Microbiome 7(1):31

DOI

66
Nissen SE (2017) Conflicts of interest and professional medical associations: progress and remaining challenges. JAMA 317 (17):1737–1738

DOI

67
O’Doherty KC, Virani A, Wilcox ES (2016) The human microbiome and public health: social and ethical considerations. Am J Public Health 106(3):414–420

DOI

68
O’Hara AM, Shanahan F (2006) The gut flora as a forgotten organ. EMBO Rep 7(7):688–693

DOI

69
Pararajasingam A, Uwagwu J (2017) Lactobacillus: the not so friendly bacteria. BMJ Case Rep 2017:bcr-2016-218423

DOI

70
Pennisi E (2017) Survey of archaea in the body reveals other microbial guests. Science 358(6366):983

DOI

71
Piovani D, Danese S, Peyrin-Biroulet L, Nikolopoulos GK, Lytras T, Bonovas S (2019) Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses. Gastroenterology 157(3):647–659.e4

DOI

72
Poussin C, Sierro N, Boué S, Battey J, Scotti E, Belcastro V, Peitsch MC, Ivanov NV, Hoeng J (2018) Interrogating the microbiome: experimental and computational considerations in support of study reproducibility. Drug Discov Today 23(9):1644–1657

DOI

73
Proctor L (2019) Priorities for the next 10 years of human microbiome research. Nature 569(7758):623–625

DOI

74
Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490(7418):55–60

DOI

75
Quince C, Walker AW, Simpson JT, Loman NJ, Segata N (2017) Shotgun metagenomics, from sampling to analysis. Nat Biotechnol 35(9):833–844

DOI

76
Rastelli M, Cani PD, Knauf C (2019) The gut microbiome influences host endocrine functions. Endocr Rev 40(5):1271–1284

DOI

77
Rehfeld JF (1998) The new biology of gastrointestinal hormones. Physiol Rev 78(4):1087–1108

DOI

78
Reynolds LA, Finlay BB (2017) Early life factors that affect allergy development. Nat Rev Immunol 17(8):518–528

DOI

79
Rhodes R (2016) Ethical issues in microbiome research and medicine. BMC Med 14(1):156

DOI

80
Richard ML, Sokol H (2019) The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases. Nat Rev Gastroenterol Hepatol 16(6):331–345

DOI

81
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science . 341(6150):1241214

DOI

82
Rooks MG, Garrett WS (2016) Gut microbiota, metabolites and host immunity. Nat Rev Immunol 16(6):341–352

DOI

83
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I (2019) Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science 365(6452): eaaw4361

DOI

84
Schiattarella GG, Sannino A, Toscano E, Giugliano G, Gargiulo G, Franzone A, Trimarco B, Esposito G, Perrino C (2017) Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis. Eur Heart J 38(39):2948–2956

DOI

85
Schloss PD (2018) Identifying and overcoming threats to reproducibility, replicability, robustness, and generalizability in microbiome research. mBio 9(3):e00525–18

DOI

86
Schmidt TSB, Raes J, Bork P (2018) The human gut microbiome: from association to modulation. Cell 172(6):1198–1215

DOI

87
Schroeder BO, Bäckhed F (2016) Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 22(10):1079–1089

DOI

88
Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O’Keefe SJ, Gaskins HR, Teare J (2019) International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. Gut 68(9):1624–1632

DOI

89
Sekirov I,Russell SL, Antunes LCM, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90(3):859–904

DOI

90
Servick K (2016) Of mice and microbes. Science 353(6301):741–743

DOI

91
Shamarina D, Stoyantcheva I, Mason CE, Bibby K, Elhaik E (2017) Communicating the promise, risks, and ethics of large-scale, open space microbiome and metagenome research. Microbiome 5(1):132

DOI

92
Shanahan F, Hill C (2019) Language, numeracy and logic in microbiome science. Nat Rev Gastroenterol Hepatol 16(7):387–388

DOI

93
Sharon G, Sampson TR, Geschwind DH, Mazmanian SK (2016) The central nervous system and the gut microbiome. Cell 167(4):915–932

DOI

94
Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH (2017) DNA sequencing at 40: past, present and future. Nature 550(7676):345–353

DOI

95
Shkoporov AN, Hill C (2019) Bacteriophages of the human gut: the “known unknown” of the microbiome. Cell Host Microbe 25 (2):195–209

DOI

96
Singh P, Mitsuhashi S, Ballou S, Rangan V, Sommers T, Cheng V,Iturrino-Moreda J, Friedlander D, Nee J, Lembo A (2018a) Demographic and dietary associations of chronic diarrhea in a representative sample of adults in the United States. Am J Gastroenterol 113(4):593–600

DOI

97
Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD, Zhang L, Wang W-B, Hao S (2018b) Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer. Cell 175(3):679–694.e22

DOI

98
Skelly AN, Sato Y, Kearney S, Honda K (2019) Mining the microbiota for microbial and metabolite-based immunotherapies. Nat Rev Immunol 19(5):305–323

DOI

99
Sox HC (2017) Conflict of interest in practice guidelines panels. JAMA 317(17):1739–1740

DOI

100
Stead WW (2017) The complex and multifaceted aspects of conflicts of interest. JAMA 317(17):1765–1767

DOI

101
Suez J, Zmora N, Zilberman-Schapira G, Mor U, Dori-Bachash M, Bashiardes S, Zur M, Regev-Lehavi D, Ben-Zeev Brik R, Federici S (2018) Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell 174(6):1406–1423.e16

DOI

102
The Lancet null (2019) Dietary supplement regulation: FDA’s bitter pill. Lancet Lond Engl 393(10173):718

DOI

103
Thornton JP (2017) Conflict of interest and legal issues for investigators and authors. JAMA 317(17):1761–1762

DOI

104
Tilg H, Zmora N, Adolph TE, Elinav E (2020) The intestinal microbiota fuelling metabolic inflammation. Nat Rev Immunol 20 (1):40–54

DOI

105
Tordesillas L, Berin MC, Sampson HA (2017) Immunology of food allergy. Immunity 47(1):32–50

DOI

106
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122):1027–1031

DOI

107
Untangle food industry influences on health (2019) Nat Med 25 (11):1629

DOI

108
Uzbay T (2019) Germ-free animal experiments in the gut microbiota studies. Curr Opin Pharmacol 49:6–10

DOI

109
Vaughn BP, Rank KM, Khoruts A (2019) Fecal microbiota transplantation: current status in treatment of gi and liver disease. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 17(2):353–361

DOI

110
Verbeke F, Janssens Y, Wynendaele E, De Spiegeleer B (2017) Faecal microbiota transplantation: a regulatory hurdle? BMC Gastroenterol 17(1):128

DOI

111
Vitiello GA, Cohen DJ, Miller G (2019) Harnessing the microbiome for pancreatic cancer immunotherapy. Trends Cancer 5(11):670–676

DOI

112
Weiner HL, da Cunha AP, Quintana F, Wu H (2011) Oral tolerance. Immunol Rev 241(1):241–259

DOI

113
Wong SH, Yu J (2019) Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol 16(11):690–704

DOI

114
Yelin I, Flett KB, Merakou C, Mehrotra P, Stam J, Snesrud E, Hinkle M, Lesho E, McGann P, McAdam AJ (2019) Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients. Nat Med 25(11):1728–1732

DOI

115
Yoo BB, Mazmanian SK (2017) The enteric network: interactions between the immune and nervous systems of the gut. Immunity 46(6):910–926

DOI

116
Yu L-X, Schwabe RF (2017) The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol 14(9):527–539

DOI

117
Yuan J, Chen C,Cui J, Lu J, Yan C,Wei X, Zhao X,Li N, Li S, Xue G et al (2019) Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae. Cell Metab 30(6):1172

DOI

118
Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M (2015) Personalized nutrition by prediction of glycemic responses. Cell 163(5):1079–1094

DOI

119
Zeilstra D, Younes JA, Brummer RJ, Kleerebezem M (2018) Perspective: fundamental limitations of the randomized controlled trial method in nutritional research: the example of probiotics. Adv Nutr Bethesda Md 9(5):561–571

DOI

120
Zhang X, Li L, Butcher J, Stintzi A, Figeys D (2019) Advancing functional and translational microbiome research using metaomics approaches. Microbiome 7(1):154

DOI

121
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, Fu H, Xue X, Lu C, Ma J et al (2018) Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science 359(6380):1151–1156

DOI

122
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019a) Separating host and microbiome contributions to drug pharmacokinetics and toxicity. Science 363(6427):eaat9931

DOI

123
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019b) Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 570(7762):462–467

DOI

124
Zmora N, Zeevi D, Korem T, Segal E, Elinav E (2016) Taking it personally: personalized utilization of the human microbiome in health and disease. Cell Host Microbe 19(1):12–20

DOI

125
Zuger A (2017) What do patients think about physicians’ conflicts of interest?: watching transparency evolve. JAMA 317(17):1747–1748

DOI

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