Seven facts and five initiatives for gut microbiome research

Danyi Li, Chunhui Gao, Faming Zhang, Ruifu Yang, Canhui Lan, Yonghui Ma, Jun Wang

PDF(359 KB)
PDF(359 KB)
Protein Cell ›› 2020, Vol. 11 ›› Issue (6) : 391-400. DOI: 10.1007/s13238-020-00697-8
COMMENTARY
COMMENTARY

Seven facts and five initiatives for gut microbiome research

Author information +
History +

Cite this article

Download citation ▾
Danyi Li, Chunhui Gao, Faming Zhang, Ruifu Yang, Canhui Lan, Yonghui Ma, Jun Wang. Seven facts and five initiatives for gut microbiome research. Protein Cell, 2020, 11(6): 391‒400 https://doi.org/10.1007/s13238-020-00697-8

References

[1]
Aagaard K, Hohmann E (2019) Regulating microbiome manipulation. Nat Med 25(6):874–876
CrossRef Google scholar
[2]
Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 15 (12):1257–1272
CrossRef Google scholar
[3]
Avetisyan M, Schill EM, Heuckeroth RO (2015) Building a second brain in the bowel. J Clin Invest 125(3):899–907
CrossRef Google scholar
[4]
Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H (2019) Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2019.1411
CrossRef Google scholar
[5]
Barnard ND, Willett WC, Ding EL (2017) The misuse of metaanalysis in nutrition research. JAMA 318(15):1435–1436
CrossRef Google scholar
[6]
Belkaid Y, Harrison OJ (2017) Homeostatic immunity and the microbiota. Immunity 46(4):562–576
CrossRef Google scholar
[7]
Bothwell LE, Podolsky SH (2016) The emergence of the randomized, controlled trial. N Engl J Med 375(6):501–504
CrossRef Google scholar
[8]
Bunyavanich S (2019) Food allergy: could the gut microbiota hold the key? Nat Rev Gastroenterol Hepatol 16(4):201–202
CrossRef Google scholar
[9]
Byndloss MX, Bäumler AJ (2018) The germ-organ theory of noncommunicable diseases. Nat Rev Microbiol 16(2):103–110
CrossRef Google scholar
[10]
Canfora EE, Meex RCR, Venema K, Blaak EE (2019) Gut microbial metabolites in obesity, NAFLD and T2DM. Nat Rev Endocrinol 15 (5):261–273
CrossRef Google scholar
[11]
Chatterjee S, Khunti K, Davies MJ (2017) Type 2 diabetes. Lancet Lond Engl 389(10085):2239–2251
CrossRef Google scholar
[12]
Clemente JC, Ursell LK, Parfrey LW, Knight R (2012) The impact of the gut microbiota on human health: an integrative view. Cell 148 (6):1258–1270
CrossRef Google scholar
[13]
Clemente JC, Manasson J, Scher JU (2018) The role of the gut microbiome in systemic inflammatory disease. BMJ 360:j5145
CrossRef Google scholar
[14]
Cohen PA (2018) Probiotic safety-no guarantees. JAMA Intern Med 178(12):1577–1578
CrossRef Google scholar
[15]
Costea PI, Zeller G, Sunagawa S, Pelletier E, Alberti A, Levenez F, Tramontano M, Driessen M, Hercog R, Jung F-E (2017) Towards standards for human fecal sample processing in metagenomic studies. Nat Biotechnol 35(11):1069–1076
CrossRef Google scholar
[16]
Crow D (2018) Microbiome research in a social world. Cell 172 (6):1143–1145
CrossRef Google scholar
[17]
Cryan JF, O’Riordan KJ, Sandhu K, Peterson V, Dinan TG (2020) The gut microbiome in neurological disorders. Lancet Neurol 19 (2):179–194
CrossRef Google scholar
[18]
Dalile B, Van Oudenhove L, Vervliet B, Verbeke K (2019) The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol 16(8):461–478
CrossRef Google scholar
[19]
Dauby N (2017) Risks of Saccharomyces boulardii-containing probiotics for the prevention of clostridium difficile infection in the elderly. Gastroenterology 153(5):1450–1451
CrossRef Google scholar
[20]
DeFilipp Z, Bloom PP, Torres Soto M, Mansour MK, Sater MRA, Huntley MH, Turbett S, Chung RT, Chen Y-B, Hohmann EL (2019) Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant. N Engl J Med 381(21):2043–2050
CrossRef Google scholar
[21]
Djulbegovic B, Guyatt GH (2017) Progress in evidence-based medicine: a quarter century on. Lancet Lond Engl 390 (10092):415–423
CrossRef Google scholar
[22]
Dominguez-Bello MG, Peterson D, Noya-Alarcon O, Bevilacqua M, Rojas N, Rodríguez R, Pinto SA, Baallow R, Caballero-Arias H (2016) Ethics of exploring the microbiome of native peoples. Nat Microbiol 1(7):16097
CrossRef Google scholar
[23]
Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M(2019) Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature 575(7783):505–511
CrossRef Google scholar
[24]
Fischbach MA (2018) Microbiome: focus on causation and mechanism. Cell 174(4):785–790
CrossRef Google scholar
[25]
Ford AC, Lacy BE, Talley NJ (2017) Irritable bowel syndrome. N Engl J Med 376(26):2566–2578
CrossRef Google scholar
[26]
Franks PW, McCarthy MI (2016) Exposing the exposures responsible for type 2 diabetes and obesity. Science 354(6308):69–73
CrossRef Google scholar
[27]
Galea S, Saitz R (2017) Funding, institutional conflicts of interest, and schools of public health: realities and solutions. JAMA 317 (17):1735–1736
CrossRef Google scholar
[28]
Garrett WS (2015) Cancer and the microbiota. Science 348 (6230):80–86
CrossRef Google scholar
[29]
Gehrig JL, Venkatesh S, Chang H-W, Hibberd MC, Kung VL, Cheng J,Chen RY, Subramanian S, Cowardin CA, Meier MF (2019) Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science 365(6449):eaau4732
CrossRef Google scholar
[30]
Gentile CL, Weir TL (2018) The gut microbiota at the intersection of diet and human health. Science 362(6416):776–780
CrossRef Google scholar
[31]
Gilbert JA, Quinn RA, Debelius J,Xu ZZ, Morton J, Garg N, Jansson JK, Dorrestein PC, Knight R (2016) Microbiome-wide association studies link dynamic microbial consortia to disease. Nature 535 (7610):94–103
CrossRef Google scholar
[32]
Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R (2018) Current understanding of the human microbiome. Nat Med 24(4):392–400
CrossRef Google scholar
[33]
Goldszmid RS, Trinchieri G (2012) The price of immunity. Nat Immunol 13(10):932–938
CrossRef Google scholar
[34]
Green JM, Barratt MJ, Kinch M, Gordon JI (2017) Food and microbiota in the FDA regulatory framework. Science 357 (6346):39–40
CrossRef Google scholar
[35]
Greenhalgh S (2019) Making China safe for coke: how Coca-Cola shaped obesity science and policy in China. BMJ 364:k5050
CrossRef Google scholar
[36]
Gribble FM, Reimann F (2019) Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol 15(4):226–237
CrossRef Google scholar
[37]
Guarino A, Canani RB (2016) Probiotics in childhood diseases: from basic science to guidelines in 20 years of research and development. J Pediatr Gastroenterol Nutr 63(Suppl 1):S1–S2
[38]
Hall AB, Tolonen AC, Xavier RJ (2017) Human genetic variation and the gut microbiome in disease. Nat Rev Genet 18(11):690–699
CrossRef Google scholar
[39]
Hanage WP (2014) Microbiology: microbiome science needs a healthy dose of scepticism. Nature 512(7514):247–248
CrossRef Google scholar
[40]
Hoffmann D, Palumbo F, Ravel J, Roghmann M-C, Rowthorn V, von Rosenvinge E (2017) Improving regulation of microbiota transplants . Science 358(6369):1390–1391
CrossRef Google scholar
[41]
Hughes HK, Landa MM, Sharfstein JM (2017) Marketing claims for infant formula: the need for evidence. JAMA Pediatr 171(2):105–106
CrossRef Google scholar
[42]
Inamo J (2019) Non-causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study. Ann Rheum Dis.https://doi.org/10.1136/annrheumdis-2019-216565
CrossRef Google scholar
[43]
Isabella VM, Ha BN, Castillo MJ, Lubkowicz DJ, Rowe SE, Millet YA, Anderson CL, Li N, Fisher AB, West KA (2018) Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat Biotechnol 36(9):857–864
CrossRef Google scholar
[44]
Iweala OI, Nagler CR (2019) The microbiome and food allergy. Annu Rev Immunol 37:377–403
CrossRef Google scholar
[45]
Jia J, Dou P, Gao M, Kong X, Li C, Liu Z, Huang T (2019) Assessment of causal direction between gut microbiota-dependent metabolites and cardiometabolic health: a bidirectional mendelian randomization analysis. Diabetes 68(9):1747–1755
CrossRef Google scholar
[46]
Johnson AJ, Vangay P, Al-Ghalith GA,Hillmann BM, Ward TL, Shields-Cutler RR, Kim AD, Shmagel AK, Syed AN, Personalized Microbiome Class Students (2019) Daily sampling reveals personalized diet-microbiome associations in humans. Cell Host Microbe 25(6):789–802.e5
CrossRef Google scholar
[47]
Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR (2006) Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes 2005 30(11):1585–1594
CrossRef Google scholar
[48]
Kivipelto M, Mangialasche F, Ngandu T (2018) Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol 14(11):653–666
CrossRef Google scholar
[49]
Kleerebezem M, Binda S, Bron PA, Gross G, Hill C, van Hylckama Vlieg JE, Lebeer S, Satokari R, Ouwehand AC (2019) Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics. Curr Opin Biotechnol 56:55–60
CrossRef Google scholar
[50]
Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J,Gonzalez A, Kosciolek T,McCall L-I, McDonald D(2018) Best practices for analysing microbiomes. Nat Rev Microbiol 16 (7):410–422
CrossRef Google scholar
[51]
Komaroff AL (2017) The microbiome and risk for obesity and diabetes. JAMA 317(4):355–356
CrossRef Google scholar
[52]
Lagier J-C, Dubourg G, Million M, Cadoret F, Bilen M, Fenollar F, Levasseur A, Rolain J-M, Fournier P-E,Raoult D (2018) Culturing the human microbiota and culturomics. Nat Rev Microbiol 16 (9):540–550
CrossRef Google scholar
[53]
Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto J-M,Kennedy S (2013) Richness of human gut microbiome correlates with metabolic markers. Nature 500(7464):541–546
CrossRef Google scholar
[54]
Levin ME, Botha M, Basera W,Facey-Thomas HE, Gaunt B, Gray CL, Kiragu W, Ramjith J, Watkins A, Genuneit J (2020) Environmental factors associated with allergy in urban and rural children from the South AFrican Food Allergy (SAFFA) cohort. J Allergy Clin Immunol 145(1):415–426
CrossRef Google scholar
[55]
Lloyd-Price J, Abu-Ali G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8(1):51
CrossRef Google scholar
[56]
Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375(24):2369–2379
CrossRef Google scholar
[57]
Manfredo Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T,Ruff W (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359(6380):1156–1161
CrossRef Google scholar
[58]
Mayer EA (2011) Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 12(8):453–466
CrossRef Google scholar
[59]
Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557(7706):580–584
CrossRef Google scholar
[60]
Miller V,Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, Dagenais G,Gupta R, Mohan V, Lear S (2017) Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study. Lancet Lond Engl 390(10107):2037–2049
CrossRef Google scholar
[61]
Mitselou N, Hallberg J, Stephansson O, Almqvist C, Melén E,Ludvigsson JF (2018) Cesarean delivery, preterm birth, and risk of food allergy: nationwide Swedish cohort study of more than 1 million children. J Allergy Clin Immunol 142(5):1510–1514.e2
CrossRef Google scholar
[62]
Mozaffarian D (2017) Conflict of interest and the role of the food industry in nutrition research. JAMA 317(17):1755–1756
CrossRef Google scholar
[63]
Nayfach S, Shi ZJ, Seshadri R, Pollard KS, Kyrpides NC (2019) New insights from uncultivated genomes of the global human gut microbiome. Nature 568(7753):505–510
CrossRef Google scholar
[64]
Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S (2012) Host-gut microbiota metabolic interactions. Science 336(6086):1262–1267
CrossRef Google scholar
[65]
NIH Human Microbiome Portfolio Analysis Team (2019) A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007–2016. Microbiome 7(1):31
CrossRef Google scholar
[66]
Nissen SE (2017) Conflicts of interest and professional medical associations: progress and remaining challenges. JAMA 317 (17):1737–1738
CrossRef Google scholar
[67]
O’Doherty KC, Virani A, Wilcox ES (2016) The human microbiome and public health: social and ethical considerations. Am J Public Health 106(3):414–420
CrossRef Google scholar
[68]
O’Hara AM, Shanahan F (2006) The gut flora as a forgotten organ. EMBO Rep 7(7):688–693
CrossRef Google scholar
[69]
Pararajasingam A, Uwagwu J (2017) Lactobacillus: the not so friendly bacteria. BMJ Case Rep 2017:bcr-2016-218423
CrossRef Google scholar
[70]
Pennisi E (2017) Survey of archaea in the body reveals other microbial guests. Science 358(6366):983
CrossRef Google scholar
[71]
Piovani D, Danese S, Peyrin-Biroulet L, Nikolopoulos GK, Lytras T, Bonovas S (2019) Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses. Gastroenterology 157(3):647–659.e4
CrossRef Google scholar
[72]
Poussin C, Sierro N, Boué S, Battey J, Scotti E, Belcastro V, Peitsch MC, Ivanov NV, Hoeng J (2018) Interrogating the microbiome: experimental and computational considerations in support of study reproducibility. Drug Discov Today 23(9):1644–1657
CrossRef Google scholar
[73]
Proctor L (2019) Priorities for the next 10 years of human microbiome research. Nature 569(7758):623–625
CrossRef Google scholar
[74]
Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490(7418):55–60
CrossRef Google scholar
[75]
Quince C, Walker AW, Simpson JT, Loman NJ, Segata N (2017) Shotgun metagenomics, from sampling to analysis. Nat Biotechnol 35(9):833–844
CrossRef Google scholar
[76]
Rastelli M, Cani PD, Knauf C (2019) The gut microbiome influences host endocrine functions. Endocr Rev 40(5):1271–1284
CrossRef Google scholar
[77]
Rehfeld JF (1998) The new biology of gastrointestinal hormones. Physiol Rev 78(4):1087–1108
CrossRef Google scholar
[78]
Reynolds LA, Finlay BB (2017) Early life factors that affect allergy development. Nat Rev Immunol 17(8):518–528
CrossRef Google scholar
[79]
Rhodes R (2016) Ethical issues in microbiome research and medicine. BMC Med 14(1):156
CrossRef Google scholar
[80]
Richard ML, Sokol H (2019) The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases. Nat Rev Gastroenterol Hepatol 16(6):331–345
CrossRef Google scholar
[81]
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science . 341(6150):1241214
CrossRef Google scholar
[82]
Rooks MG, Garrett WS (2016) Gut microbiota, metabolites and host immunity. Nat Rev Immunol 16(6):341–352
CrossRef Google scholar
[83]
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I (2019) Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science 365(6452): eaaw4361
CrossRef Google scholar
[84]
Schiattarella GG, Sannino A, Toscano E, Giugliano G, Gargiulo G, Franzone A, Trimarco B, Esposito G, Perrino C (2017) Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis. Eur Heart J 38(39):2948–2956
CrossRef Google scholar
[85]
Schloss PD (2018) Identifying and overcoming threats to reproducibility, replicability, robustness, and generalizability in microbiome research. mBio 9(3):e00525–18
CrossRef Google scholar
[86]
Schmidt TSB, Raes J, Bork P (2018) The human gut microbiome: from association to modulation. Cell 172(6):1198–1215
CrossRef Google scholar
[87]
Schroeder BO, Bäckhed F (2016) Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 22(10):1079–1089
CrossRef Google scholar
[88]
Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O’Keefe SJ, Gaskins HR, Teare J (2019) International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. Gut 68(9):1624–1632
CrossRef Google scholar
[89]
Sekirov I,Russell SL, Antunes LCM, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90(3):859–904
CrossRef Google scholar
[90]
Servick K (2016) Of mice and microbes. Science 353(6301):741–743
CrossRef Google scholar
[91]
Shamarina D, Stoyantcheva I, Mason CE, Bibby K, Elhaik E (2017) Communicating the promise, risks, and ethics of large-scale, open space microbiome and metagenome research. Microbiome 5(1):132
CrossRef Google scholar
[92]
Shanahan F, Hill C (2019) Language, numeracy and logic in microbiome science. Nat Rev Gastroenterol Hepatol 16(7):387–388
CrossRef Google scholar
[93]
Sharon G, Sampson TR, Geschwind DH, Mazmanian SK (2016) The central nervous system and the gut microbiome. Cell 167(4):915–932
CrossRef Google scholar
[94]
Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH (2017) DNA sequencing at 40: past, present and future. Nature 550(7676):345–353
CrossRef Google scholar
[95]
Shkoporov AN, Hill C (2019) Bacteriophages of the human gut: the “known unknown” of the microbiome. Cell Host Microbe 25 (2):195–209
CrossRef Google scholar
[96]
Singh P, Mitsuhashi S, Ballou S, Rangan V, Sommers T, Cheng V,Iturrino-Moreda J, Friedlander D, Nee J, Lembo A (2018a) Demographic and dietary associations of chronic diarrhea in a representative sample of adults in the United States. Am J Gastroenterol 113(4):593–600
CrossRef Google scholar
[97]
Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD, Zhang L, Wang W-B, Hao S (2018b) Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer. Cell 175(3):679–694.e22
CrossRef Google scholar
[98]
Skelly AN, Sato Y, Kearney S, Honda K (2019) Mining the microbiota for microbial and metabolite-based immunotherapies. Nat Rev Immunol 19(5):305–323
CrossRef Google scholar
[99]
Sox HC (2017) Conflict of interest in practice guidelines panels. JAMA 317(17):1739–1740
CrossRef Google scholar
[100]
Stead WW (2017) The complex and multifaceted aspects of conflicts of interest. JAMA 317(17):1765–1767
CrossRef Google scholar
[101]
Suez J, Zmora N, Zilberman-Schapira G, Mor U, Dori-Bachash M, Bashiardes S, Zur M, Regev-Lehavi D, Ben-Zeev Brik R, Federici S (2018) Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell 174(6):1406–1423.e16
CrossRef Google scholar
[102]
The Lancet null (2019) Dietary supplement regulation: FDA’s bitter pill. Lancet Lond Engl 393(10173):718
CrossRef Google scholar
[103]
Thornton JP (2017) Conflict of interest and legal issues for investigators and authors. JAMA 317(17):1761–1762
CrossRef Google scholar
[104]
Tilg H, Zmora N, Adolph TE, Elinav E (2020) The intestinal microbiota fuelling metabolic inflammation. Nat Rev Immunol 20 (1):40–54
CrossRef Google scholar
[105]
Tordesillas L, Berin MC, Sampson HA (2017) Immunology of food allergy. Immunity 47(1):32–50
CrossRef Google scholar
[106]
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122):1027–1031
CrossRef Google scholar
[107]
Untangle food industry influences on health (2019) Nat Med 25 (11):1629
CrossRef Google scholar
[108]
Uzbay T (2019) Germ-free animal experiments in the gut microbiota studies. Curr Opin Pharmacol 49:6–10
CrossRef Google scholar
[109]
Vaughn BP, Rank KM, Khoruts A (2019) Fecal microbiota transplantation: current status in treatment of gi and liver disease. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 17(2):353–361
CrossRef Google scholar
[110]
Verbeke F, Janssens Y, Wynendaele E, De Spiegeleer B (2017) Faecal microbiota transplantation: a regulatory hurdle? BMC Gastroenterol 17(1):128
CrossRef Google scholar
[111]
Vitiello GA, Cohen DJ, Miller G (2019) Harnessing the microbiome for pancreatic cancer immunotherapy. Trends Cancer 5(11):670–676
CrossRef Google scholar
[112]
Weiner HL, da Cunha AP, Quintana F, Wu H (2011) Oral tolerance. Immunol Rev 241(1):241–259
CrossRef Google scholar
[113]
Wong SH, Yu J (2019) Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol 16(11):690–704
CrossRef Google scholar
[114]
Yelin I, Flett KB, Merakou C, Mehrotra P, Stam J, Snesrud E, Hinkle M, Lesho E, McGann P, McAdam AJ (2019) Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients. Nat Med 25(11):1728–1732
CrossRef Google scholar
[115]
Yoo BB, Mazmanian SK (2017) The enteric network: interactions between the immune and nervous systems of the gut. Immunity 46(6):910–926
CrossRef Google scholar
[116]
Yu L-X, Schwabe RF (2017) The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol 14(9):527–539
CrossRef Google scholar
[117]
Yuan J, Chen C,Cui J, Lu J, Yan C,Wei X, Zhao X,Li N, Li S, Xue G et al (2019) Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae. Cell Metab 30(6):1172
CrossRef Google scholar
[118]
Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M (2015) Personalized nutrition by prediction of glycemic responses. Cell 163(5):1079–1094
CrossRef Google scholar
[119]
Zeilstra D, Younes JA, Brummer RJ, Kleerebezem M (2018) Perspective: fundamental limitations of the randomized controlled trial method in nutritional research: the example of probiotics. Adv Nutr Bethesda Md 9(5):561–571
CrossRef Google scholar
[120]
Zhang X, Li L, Butcher J, Stintzi A, Figeys D (2019) Advancing functional and translational microbiome research using metaomics approaches. Microbiome 7(1):154
CrossRef Google scholar
[121]
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, Fu H, Xue X, Lu C, Ma J et al (2018) Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science 359(6380):1151–1156
CrossRef Google scholar
[122]
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019a) Separating host and microbiome contributions to drug pharmacokinetics and toxicity. Science 363(6427):eaat9931
CrossRef Google scholar
[123]
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019b) Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 570(7762):462–467
CrossRef Google scholar
[124]
Zmora N, Zeevi D, Korem T, Segal E, Elinav E (2016) Taking it personally: personalized utilization of the human microbiome in health and disease. Cell Host Microbe 19(1):12–20
CrossRef Google scholar
[125]
Zuger A (2017) What do patients think about physicians’ conflicts of interest?: watching transparency evolve. JAMA 317(17):1747–1748
CrossRef Google scholar

RIGHTS & PERMISSIONS

2020 The Author(s)
AI Summary AI Mindmap
PDF(359 KB)

Accesses

Citations

Detail

Sections
Recommended

/