Lifting the veil on the keratinocyte contribution to cutaneous nociception
Received date: 26 Jul 2019
Accepted date: 16 Dec 2019
Published date: 15 Apr 2020
Copyright
Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions.
Key words: keratinocyte; nociception; skin; TRP; pain; inflammation
Matthieu Talagas , Nicolas Lebonvallet , François Berthod , Laurent Misery . Lifting the veil on the keratinocyte contribution to cutaneous nociception[J]. Protein & Cell, 2020 , 11(4) : 239 -250 . DOI: 10.1007/s13238-019-00683-9
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