LETTER

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

  • Paloma Martinez-Redondo 1 ,
  • Isabel Guillen-Guillen 1,5 ,
  • Noah Davidsohn 2,3 ,
  • Chao Wang 1 ,
  • Javier Prieto 1 ,
  • Masakazu Kurita 1 ,
  • Fumiyuki Hatanaka 1 ,
  • Cuiqing Zhong 1 ,
  • Reyna Hernandez-Benitez 1 ,
  • Tomoaki Hishida 1 ,
  • Takashi Lezaki 1 ,
  • Akihisa Sakamoto 1 ,
  • Amy N. Nemeth 1 ,
  • Yuriko Hishida 1 ,
  • Concepcion Rodriguez Esteban 1 ,
  • Kensaku Shojima 1 ,
  • Ling Huang 4 ,
  • Maxim Shokhirev 4 ,
  • Estrella Nuñez-Delicado 3 ,
  • Josep M. Campistol 6 ,
  • Isabel Guillen-Vicente 7 ,
  • Elena Rodriguez-Iñigo 7 ,
  • Juan Manuel Lopez-Alcorocho 7 ,
  • Marta Guillen-Vicente 7 ,
  • George Church 2,3 ,
  • Pradeep Reddy 1 ,
  • Pedro Guillen-Garcia , 7 ,
  • Guang-Hui Liu , 8,9,10,11 ,
  • Juan Carlos Izpisua Belmonte , 1
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  • 1. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
  • 2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02115, USA
  • 3. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
  • 4. Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
  • 5. Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, No 135 12, 30107 Guadalupe, Spain
  • 6. Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain
  • 7. Department of Traumatology and Research Unit, Clinica CEMTRO, 28035 Madrid, Spain
  • 8. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 9. University of Chinese Academy of Sciences, Beijing 100049, China
  • 10. Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 11. Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Published date: 15 Mar 2020

Copyright

2020 The Author(s) 2020

Cite this article

Paloma Martinez-Redondo , Isabel Guillen-Guillen , Noah Davidsohn , Chao Wang , Javier Prieto , Masakazu Kurita , Fumiyuki Hatanaka , Cuiqing Zhong , Reyna Hernandez-Benitez , Tomoaki Hishida , Takashi Lezaki , Akihisa Sakamoto , Amy N. Nemeth , Yuriko Hishida , Concepcion Rodriguez Esteban , Kensaku Shojima , Ling Huang , Maxim Shokhirev , Estrella Nuñez-Delicado , Josep M. Campistol , Isabel Guillen-Vicente , Elena Rodriguez-Iñigo , Juan Manuel Lopez-Alcorocho , Marta Guillen-Vicente , George Church , Pradeep Reddy , Pedro Guillen-Garcia , Guang-Hui Liu , Juan Carlos Izpisua Belmonte . αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model[J]. Protein & Cell, 2020 , 11(3) : 219 -226 . DOI: 10.1007/s13238-019-00685-7

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