Tissue-resident memory-like ILCs: innate counterparts of TRM cells
Received date: 16 May 2019
Accepted date: 18 Jun 2019
Published date: 15 Feb 2020
Copyright
Innate lymphoid cells (ILCs) are defined as lymphocytes that lack RAG recombinase and do not express diverse antigen receptors; however, recent studies have revealed the adaptive features of ILCs. Mouse cytome-galovirus (MCMV)- and cytokine-induced memory natu-ral killer (NK) cells circulate in the blood and are referred to as conventional memory NK cells. In contrast, virus- and hapten-induced memory NK cells, hapten-induced memory ILC1s, and cytokine-induced memory-like ILC2s exhibit long-term residency in the liver or lung, and are referred to as tissue-resident memory ILCs. Considering their similar migration patterns and mem- ory potential, tissue-resident memory ILCs could be regarded as innate counterparts of resident memory T (TRM) cells. Both tissue-resident memory ILCs and TRM cells share common characteristics in terms of dynam- ics, phenotype, and molecular regulation. The emer-gence of ILC memory expands the basic biology of ILCs and prompts us to re-examine their functions in disease progression. This review discusses the evidence sup-porting tissue-resident memory NK cells and other memory ILC subsets, compares them with TRM cells, and highlights key unsolved questions in this emerging field.
Key words: tissue-residency; innate lymphoid cells; immunological memory; TRM cells
Xianwei Wang , Zhigang Tian , Hui Peng . Tissue-resident memory-like ILCs: innate counterparts of TRM cells[J]. Protein & Cell, 2020 , 11(2) : 85 -96 . DOI: 10.1007/s13238-019-0647-7
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