JMJD3 in the regulation of human diseases
Received date: 27 Nov 2018
Accepted date: 11 Jun 2019
Published date: 15 Dec 2019
Copyright
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyllysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
Key words: histone methylation; JMJD3; epigenetics; human diseases
Xiangxian Zhang , Li Liu , Xia Yuan , Yuquan Wei , Xiawei Wei . JMJD3 in the regulation of human diseases[J]. Protein & Cell, 2019 , 10(12) : 864 -882 . DOI: 10.1007/s13238-019-0653-9
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