Protein & Cell >

2019 , Vol. 10 >Issue 8: 610 - 614

DOI: https://doi.org/10.1007/s13238-019-0621-4

LETTER

VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration

  • Song Chen 1,2 ,
  • Shuo Luo 1 ,
  • Zhe Zhang 1 ,
  • Dengke K. Ma , 1
Expand
  • 1. Cardiovascular Research Institute and Department of Physiology, University of California San Francisco (UCSF), San Francisco, CA 94158, USA
  • 2. Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

Published date: 15 Aug 2019

Copyright

2019 The Author(s) 2019
Fold

Cite this article

Song Chen , Shuo Luo , Zhe Zhang , Dengke K. Ma . VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration[J]. Protein & Cell, 2019 , 10(8) : 610 -614 . DOI: 10.1007/s13238-019-0621-4

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Choi W-S, Kim H-W, Tronche F, Palmiter RD, Storm DR, Xia Z (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

DOI

2
Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM (2017) Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci USA 114(21):E4241–E4250

DOI

3
Flames N, Hobert O (2009) Gene regulatory logic of dopaminergic neuron differentiation. Nature 458:885–889

DOI

4
Guo R, Zong S, Wu M, Gu J, Yang M (2017) Architecture of human mitochondrial respiratory megacomplex I2III2IV2. Cell 170(1247–1257):e12

DOI

5
Hirst J (2013) Mitochondrial complex I. Annu Rev Biochem 82:551–575

DOI

6
Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE et al (2016) Hypoxia as a therapy for mitochondrial disease. Science 352(6281):54–61

DOI

7
Letts JA, Sazanov LA (2017) Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain. Nat Struct Mol Biol 24:800–808

DOI

8
Murphy MP, Smith RAJ (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47:629–656

DOI

9
Rauthan M, Ranji P, Abukar R, Pilon M (2015) A mutation in Caenorhabditis elegans NDUF-7 activates the mitochondrial stress response and prolongs lifespan via ROS and CED-4. G3 Genes Genomes Genet 5:1639–1648

DOI

10
Shen C, Powell-Coffman JA (2003) Genetic analysis of hypoxia signaling and response in C. elegans. Ann N Y Acad Sci 995:191–199

DOI

Options
Outlines

/

〈 〉