VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration

Song Chen , Shuo Luo , Zhe Zhang , Dengke K. Ma

Protein Cell ›› 2019, Vol. 10 ›› Issue (8) : 610 -614.

PDF (2166KB)
Protein Cell ›› 2019, Vol. 10 ›› Issue (8) : 610 -614. DOI: 10.1007/s13238-019-0621-4
LETTER
LETTER

VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration

Author information +
History +
PDF (2166KB)

Cite this article

Download citation ▾
Song Chen, Shuo Luo, Zhe Zhang, Dengke K. Ma. VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration. Protein Cell, 2019, 10(8): 610-614 DOI:10.1007/s13238-019-0621-4

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Choi W-S, Kim H-W, Tronche F, Palmiter RD, Storm DR, Xia Z (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

[2]

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM (2017) Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci USA 114(21):E4241–E4250

[3]

Flames N, Hobert O (2009) Gene regulatory logic of dopaminergic neuron differentiation. Nature 458:885–889

[4]

Guo R, Zong S, Wu M, Gu J, Yang M (2017) Architecture of human mitochondrial respiratory megacomplex I2III2IV2. Cell 170(1247–1257):e12

[5]

Hirst J (2013) Mitochondrial complex I. Annu Rev Biochem 82:551–575

[6]

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE et al (2016) Hypoxia as a therapy for mitochondrial disease. Science 352(6281):54–61

[7]

Letts JA, Sazanov LA (2017) Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain. Nat Struct Mol Biol 24:800–808

[8]

Murphy MP, Smith RAJ (2007) Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 47:629–656

[9]

Rauthan M, Ranji P, Abukar R, Pilon M (2015) A mutation in Caenorhabditis elegans NDUF-7 activates the mitochondrial stress response and prolongs lifespan via ROS and CED-4. G3 Genes Genomes Genet 5:1639–1648

[10]

Shen C, Powell-Coffman JA (2003) Genetic analysis of hypoxia signaling and response in C. elegans. Ann N Y Acad Sci 995:191–199

RIGHTS & PERMISSIONS

The Author(s) 2019

AI Summary AI Mindmap
PDF (2166KB)

714

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/