RESEARCH ARTICLE

Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade

  • Jiaxing Cui 1 ,
  • Hongfei Cui 1,3 ,
  • Mingran Yang 1 ,
  • Shiyu Du 2 ,
  • Junfeng Li 1 ,
  • Yingxue Li 1 ,
  • Liyang Liu 1 ,
  • Xuegong Zhang , 1,4 ,
  • Shao Li , 1,4
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  • 1. MOE Key Laboratory of Bioinformatics and TCM-X center/Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing 100084, China
  • 2. China-Japan Friendship Hospital, Beijing 100029, China
  • 3. Institute for Artificial Intelligence and Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
  • 4. School of Life Sciences and Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China

Received date: 18 Sep 2018

Accepted date: 23 Oct 2018

Published date: 15 Jul 2019

Copyright

2018 The Author(s)

Abstract

The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.

Cite this article

Jiaxing Cui , Hongfei Cui , Mingran Yang , Shiyu Du , Junfeng Li , Yingxue Li , Liyang Liu , Xuegong Zhang , Shao Li . Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade[J]. Protein & Cell, 2019 , 10(7) : 496 -509 . DOI: 10.1007/s13238-018-0596-6

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