Protein & Cell >

2019 , Vol. 10 >Issue 5: 370 - 375

DOI: https://doi.org/10.1007/s13238-018-0591-y

LETTER

Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

  • Huanyin Tang 1 ,
  • Anke Geng 1 ,
  • Tengjiao Zhang 2 ,
  • Chen Wang 2 ,
  • Ying Jiang 1 ,
  • Zhiyong Mao , 1
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  • 1. Clinical and Translational Research Center of Shanghai First Maternity Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
  • 2. School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

Published date: 15 May 2019

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2018 The Author(s) 2018. This article is an open access publication
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Cite this article

Huanyin Tang , Anke Geng , Tengjiao Zhang , Chen Wang , Ying Jiang , Zhiyong Mao . Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion[J]. Protein & Cell, 2019 , 10(5) : 370 -375 . DOI: 10.1007/s13238-018-0591-y

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15:978–990

DOI

2
Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685–705

DOI

3
Chandra T, Ewels PA, Schoenfelder S, Furlan-Magaril M, Wingett SW, Kirschner K, Thuret JY, Andrews S, Fraser P, Reik WT (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Rep 10:471–483

DOI

4
Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585–621

DOI

5
Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R (2016) NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18:979–992

DOI

6
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657–667

DOI

7
Lamming DW, Ye L, Sabatini DM, Baur JA (2013) Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Investig 123:980–989

DOI

8
Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas AR, Kamitaki N, Martersteck EM (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161:1202–1214

DOI

9
Mao Z, Ke Z, Gorbunova V, Seluanov A (2012) Replicatively senescent cells are arrested in G1 and G2 phases. Aging 4:431–435

DOI

10
Munoz-Espin D, Serrano M (2014) Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 15:482–496

DOI

11
Rao SG, Jackson JG (2016) SASP: tumor suppressor or promoter? Yes! Trends Cancer 2:676–687

DOI

12
Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J (2017) Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16:1043–1050

DOI

13
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246–1256

DOI

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