Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

Huanyin Tang , Anke Geng , Tengjiao Zhang , Chen Wang , Ying Jiang , Zhiyong Mao

Protein Cell ›› 2019, Vol. 10 ›› Issue (5) : 370 -375.

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Protein Cell ›› 2019, Vol. 10 ›› Issue (5) : 370 -375. DOI: 10.1007/s13238-018-0591-y
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Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

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Huanyin Tang, Anke Geng, Tengjiao Zhang, Chen Wang, Ying Jiang, Zhiyong Mao. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion. Protein Cell, 2019, 10(5): 370-375 DOI:10.1007/s13238-018-0591-y

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References

[1]

Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15:978–990

[2]

Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685–705

[3]

Chandra T, Ewels PA, Schoenfelder S, Furlan-Magaril M, Wingett SW, Kirschner K, Thuret JY, Andrews S, Fraser P, Reik WT (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Rep 10:471–483

[4]

Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585–621

[5]

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R (2016) NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18:979–992

[6]

Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657–667

[7]

Lamming DW, Ye L, Sabatini DM, Baur JA (2013) Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Investig 123:980–989

[8]

Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas AR, Kamitaki N, Martersteck EM (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161:1202–1214

[9]

Mao Z, Ke Z, Gorbunova V, Seluanov A (2012) Replicatively senescent cells are arrested in G1 and G2 phases. Aging 4:431–435

[10]

Munoz-Espin D, Serrano M (2014) Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 15:482–496

[11]

Rao SG, Jackson JG (2016) SASP: tumor suppressor or promoter? Yes! Trends Cancer 2:676–687

[12]

Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J (2017) Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16:1043–1050

[13]

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246–1256

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