LETTER

TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages

  • Xiang Zhang 1,2,3 ,
  • Xiaoyu Li 1,2 ,
  • Fei Ning 1,2,3 ,
  • Yingli Shang 4 ,
  • Xiaoyu Hu , 1,2,5
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  • 1. Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China
  • 2. Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China
  • 3. School of Life Sciences, Tsinghua University, Beijing 100084, China
  • 4. College of Veterinary Medicine, Shandong Agricultural University, Taian 271018, China
  • 5. Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, China

Published date: 12 Apr 2019

Copyright

2018 The Author(s) 2018

Cite this article

Xiang Zhang , Xiaoyu Li , Fei Ning , Yingli Shang , Xiaoyu Hu . TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages[J]. Protein & Cell, 2019 , 10(4) : 300 -305 . DOI: 10.1007/s13238-018-0554-3

1
Buscarlet M, Stifani S (2007) The ‘Marx’ of Groucho on development and disease. Trends Cell Biol 17:353–361

DOI

2
Chen G, Courey AJ (2000) Groucho/TLE family proteins and transcriptional repression. Gene 249:1–16

DOI

3
Guo XK, Ou J, Liang S, Zhou X, Hu X (2018) Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis. Mucosal Immunol. https://doi.org/10.1038/mi.2017.111

DOI

4
Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M (2008) Integrated regulation of Toll-like receptor responses by Notch and Interferon-γ pathways. Immunity 29:691–703

DOI

5
Kishimoto T (2005) INTERLEUKIN-6: from basic science to medicine—40 years in immunology. Annu Rev Immunol 23:1–21

DOI

6
Kobayashi T, Kageyama R (2014) Expression dynamics and functions of Hes factors in development and diseases. In: Taneja R (ed) Current topics in developmental biology. Academic Press, New York, pp 263–283

DOI

7
Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F (2008) Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev 226:112–131

DOI

8
Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14:329

DOI

9
Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ (2016) Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-kappaB inflammatory pathway. Proc Natl Acad Sci USA 113:1871–1876

DOI

10
Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B (2016a) The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nat Immunol 17:930–937

DOI

11
Shang Y, Smith S, Hu X (2016b) Role of Notch signaling in regulating innate immunity and inflammation in health and disease. Protein Cell 7:159–174

DOI

12
Staal FJ, Luis TC, Tiemessen MM (2008) WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 8:581–593

DOI

13
Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133–146

DOI

14
Ueo T, Imayoshi I, Kobayashi T, Ohtsuka T, Seno H, Nakase H, Chiba T, Kageyama R (2012) The role of Hes genes in intestinal development, homeostasis and tumor formation. Development 139:1071–1082

DOI

15
Wheat JC, Krause DS, Shin TH, Chen X, Wang J, Ding D, Yamin R, Sweetser DA (2014) The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development. PLoS ONE 9: e105557

DOI

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