TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages

Xiang Zhang, Xiaoyu Li, Fei Ning, Yingli Shang, Xiaoyu Hu

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PDF(445 KB)
Protein Cell ›› 2019, Vol. 10 ›› Issue (4) : 300-305. DOI: 10.1007/s13238-018-0554-3
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TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages

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Xiang Zhang, Xiaoyu Li, Fei Ning, Yingli Shang, Xiaoyu Hu. TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages. Protein Cell, 2019, 10(4): 300‒305 https://doi.org/10.1007/s13238-018-0554-3

References

[1]
Buscarlet M, Stifani S (2007) The ‘Marx’ of Groucho on development and disease. Trends Cell Biol 17:353–361
CrossRef Google scholar
[2]
Chen G, Courey AJ (2000) Groucho/TLE family proteins and transcriptional repression. Gene 249:1–16
CrossRef Google scholar
[3]
Guo XK, Ou J, Liang S, Zhou X, Hu X (2018) Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis. Mucosal Immunol. https://doi.org/10.1038/mi.2017.111
CrossRef Google scholar
[4]
Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M (2008) Integrated regulation of Toll-like receptor responses by Notch and Interferon-γ pathways. Immunity 29:691–703
CrossRef Google scholar
[5]
Kishimoto T (2005) INTERLEUKIN-6: from basic science to medicine—40 years in immunology. Annu Rev Immunol 23:1–21
CrossRef Google scholar
[6]
Kobayashi T, Kageyama R (2014) Expression dynamics and functions of Hes factors in development and diseases. In: Taneja R (ed) Current topics in developmental biology. Academic Press, New York, pp 263–283
CrossRef Google scholar
[7]
Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F (2008) Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev 226:112–131
CrossRef Google scholar
[8]
Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14:329
CrossRef Google scholar
[9]
Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ (2016) Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-kappaB inflammatory pathway. Proc Natl Acad Sci USA 113:1871–1876
CrossRef Google scholar
[10]
Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B (2016a) The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nat Immunol 17:930–937
CrossRef Google scholar
[11]
Shang Y, Smith S, Hu X (2016b) Role of Notch signaling in regulating innate immunity and inflammation in health and disease. Protein Cell 7:159–174
CrossRef Google scholar
[12]
Staal FJ, Luis TC, Tiemessen MM (2008) WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 8:581–593
CrossRef Google scholar
[13]
Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133–146
CrossRef Google scholar
[14]
Ueo T, Imayoshi I, Kobayashi T, Ohtsuka T, Seno H, Nakase H, Chiba T, Kageyama R (2012) The role of Hes genes in intestinal development, homeostasis and tumor formation. Development 139:1071–1082
CrossRef Google scholar
[15]
Wheat JC, Krause DS, Shin TH, Chen X, Wang J, Ding D, Yamin R, Sweetser DA (2014) The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development. PLoS ONE 9: e105557
CrossRef Google scholar

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