Protein & Cell >

2019 , Vol. 10 >Issue 2: 137 - 142

DOI: https://doi.org/10.1007/s13238-018-0604-x

LETTER

Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

  • Guangshun Zhang 1,2,4,5 ,
  • Junyuan Cao 1,3 ,
  • Yan Cai 2,4,5 ,
  • Yang Liu 1 ,
  • Yanli Li 2,4,5 ,
  • Peilin Wang 1,3 ,
  • Jiao Guo 1,3 ,
  • Xiaoying Jia 1,3 ,
  • Mengmeng Zhang 2,4,5 ,
  • Gengfu Xiao 1,3 ,
  • Yu Guo 2,4,5 ,
  • Wei Wang , 1,3
Expand
  • 1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
  • 2. College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300450, China
  • 3. University of the Chinese Academy of Sciences, Beijing 100049, China
  • 4. Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300071, China
  • 5. Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300450, China

Published date: 31 Jan 2019

Copyright

2019 The Author(s) 2019
Fold

Cite this article

Guangshun Zhang , Junyuan Cao , Yan Cai , Yang Liu , Yanli Li , Peilin Wang , Jiao Guo , Xiaoying Jia , Mengmeng Zhang , Gengfu Xiao , Yu Guo , Wei Wang . Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2[J]. Protein & Cell, 2019 , 10(2) : 137 -142 . DOI: 10.1007/s13238-018-0604-x

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Amberg SM, Bolken TC, Hruby DE, Dai D (2013a) Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus. Bioorg Med Chem Lett 23:5840–5843

DOI

2
Burgeson JR, Moore AL, Gharaibeh DN, Larson RA, Cerruti NR, Amberg SM, Hruby DE, Dai D (2013b) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett 23:750–756

DOI

3
Dai D, Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Cerruti NR, Amberg SM, Bolken TC, Hruby DE (2013) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole. Bioorg Med Chem Lett 23:744–749

DOI

4
Grigoryan, G. (2011). DrawCoil 1.0.

5
Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO (2017) Structural basis for antibody-mediated neutralization of Lassa virus. Science 356:923–928

DOI

6
Larson RA, Dai D, Hosack VT, Tan Y, Bolken TC, Hruby DE, Amberg SM (2008) Identification of a broad-spectrum arenavirus entry inhibitor. J Virol 82:10768–10775

DOI

7
Lee AM, Rojek JM, Spiropoulou CF, Gundersen AT, Jin W, Shaginian A, York J, Nunberg JH, Boger DL, Oldstone MB (2008) Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem 283:18734–18742

DOI

8
Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W (2001) The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc Natl Acad Sci U S A 98:12701–12705

DOI

9
Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH (2016) Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein. J Virol 90:6799–6807

DOI

10
Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR (2011) A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus. J Biol Chem 286:6192–6200

DOI

11
Wang P, Liu Y, Zhang G, Wang S, Guo J, Cao J, Jia X, Zhang L, Xiao G, Wang W (2018) Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drugs Library. J Virol 92: JVI–00954

DOI

12
Wang W, Zhou Z, Zhang L, Wang S, Xiao G (2016) Structurefunction relationship of the mammarenavirus envelope glycoprotein. Virol Sin 31:380–394

DOI

13
York J, Dai D, Amberg SM, Nunberg JH (2008) pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol 82:10932–10939

DOI

14
York J, Nunberg JH (2009) Intersubunit interactions modulate pHinduced activation of membrane fusion by the Junin virus envelope glycoprotein GPC. J Virol 83:4121–4126

DOI

Options
Outlines

/

〈 〉